α-Lipoic Acid
14 Inquiries
1077-28-7
95%
2026-08-06
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName α-Lipoic Acid Cat No COEC-041 Description α-Lipoic Acid is a metabolic antioxidant that regulates NFκB signal transduction and can protect against oxidative injury. The exogenous compound is reduced intracellularly by enzymes. Its reduced form is involved in radical scavenging, recycling of other antioxidants, accelerating GSH synthesis, and regulating transcription factor activity, specifically NFkappaB. It also acts as a conenzyme that is required for the activity of pyruvate dehydrogenase and glycine decarboxylase, among other enzyme complexes. Studies show that it can prevent a decrease in the renal antioxidant defense system and prevent the increase of lipid peroxidation, platinum content and plasma creatinine concentrations. In other studies, lipoic acid decreased the phagocytosis of myelin by macrophages, acting as a non-specific scavenger of reactive oxygen species (ROS). Applications A metabolic antioxidant that regulates NF-κB signal transduction Form Solid CAS No 1077-28-7 Molecular Weight 206.32 Purity ≥95% Synonyms DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid Molecular Formula C8H14O2S2 Melting Point 160 to 165°C Solubility Solubility Soluble in ethanol or methanol Boiling Point 362.5°C Refractive Index ~1.75 (Predicted) category Vitamins and Minerals Medicines(c1424) cas_num 1077-28-7 Basic Info-
Product Name:
(±)-Lipoic acid
Other Name:1,2-Dithiolane-3-pentanoic acid;1,2-Dithiolane-3-valeric acid,(±)-;1,2-Dithiolane-3-pentanoic acid,(±)-;dl-Thioctic acid;DL-α-Lipoic acid;DL-6-Thioctic acid;DL-6,8-Thioctic acid;(±)-Thioctic acid;(±)-α-Lipoic acid;DL-Thioctic acid;(RS)-Lipoic acid;(RS)-α-Lipoic acid;5-(1,2-Dithiolan-3-yl)pentanoic acid;5-(1,2-Dithiolan-3-yl)valeric acid;Protogen A;Pyruvate oxidation factor;Thioctacid;Thioctic acid;6,8-Thioctic acid;Tioctidasi;Tioctidasi acetate replacing factor;1,2-Dithiolane-3-valeric acid;6-Thioctic acid;α-Liponic acid;Tioctacid;Biletan;Thioctsan;Liposan;Lipothion;(±)-Lipoic acid;NSC 628502;dl-Lipoic acid;NSC 90788;Alipure;Espa-lipon;Thiotacid;dl-α-Lipoic acid;α-lipon 300;α-(±)-Lipoic acid;DL-Lipoic acid;Byodinoral-R;Octolipen;Oktolipen;62-46-4;27779-68-6
CAS No.:1077-28-7
Molecular Formula:C8H14O2S2
InChIKeys:InChIKey=AGBQKNBQESQNJD-UHFFFAOYSA-N
Molecular Weight:206.32600
Exact Mass:206.33
EC Number:200-534-6
NSC Number:758651|90788
DSSTox ID:DTXSID7025508
Color/Form:Forms yellowish flakes
ATC Code:A - Alimentary tract and metabolism
HScode:2934999090
Categories:
Characteristics-
PSA:
87.90000
XLogP3:2.78510
Appearance:light yellow to yellow powder
Density:1.218g/cm3
Melting Point:60-61 °C
Boiling Point:160-165 °C
Flash Point:173ºC
Refractive Index:1.562
Water Solubility:ethanol: 50 mg/mL | 0.9 g/L (20 ºC);In water, 127 mg/L at 25 deg C (est)
Storage Conditions:2-8ºC
Vapor Pressure:9.49X10-1 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 1.64X10-8 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa = 5.10|pKa = 4.70 (carboxy) (est)
Collision Cross Section:133.8 Ų [M+H-H2O]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]
Experimental Properties:White powder, soluble in water, pH of aqueous solutions about 7.4 /Thioctic acid, sodium salt/|Crystals by vacuum sublimation (at 85-90 °C and 25 micron). MP: 46-48 °C (microblock). Specific optical rotation: + 104 deg at 23 °C/D (c = 0.88 in benzene). UV max (methanol): 333 nm (epsilon 150). pKa = 5.4. Practically insoluble in water. Soluble in fat solvents. /Thioctic acid, d-form/|Yellow needles from cyclohexane. MP: 60-61 °C. BP: 160-165 °C. Practically insoluble in water; soluble in fat solvents. Forms a water-soluble sodium salt. /Thioctic acid, dl-form/|Crystals from cyclohexane. MP: 45-47.5 °C (microblock). Specific optical rotation: -113 deg at 23 °C/D (c = 1.88 in benzene). UV max (methanol): 330 nm (epsilon 140). /Thioctic acid, l-form/|Hydroxyl radical reaction rate constant = 2.52X10-10 cu m/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Skin sensitization, Category 1
Eye irritation, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H411 Toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P333+P317 If skin irritation or rash occurs: Get medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P391 Collect spillage.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History14 Inquiries
Country Product Purchase Quantity Date Posted 
India
DL-Thioctic acid
25 KG Jan 6, 2025
India
Alpha Lipoic Acid
1.00 MT Jun 29, 2026 
Brazil
Alpha L Acid
1 KG Apr 16, 2026 
Turkey
Thioctic Acid
600 MG Feb 25, 2025 
Thailand
Alpha Lipoic Acid
1 KG Jan 22, 2025 
Egypt
alpha lipoic acid
2 MT Jul 21, 2024
Egypt
Thioctic acid 99% Yellow powder
500 KG Oct 18, 2023
Turkey
Factory Price Alpha Lipoic Acid ALA 99% from China
200 KG Aug 2, 2023
Egypt
Alpha Lipoic Acid Powder
200.00 KG Feb 24, 2025
India
Alpha Lipoic Acid
300 KG Dec 26, 2024
India
Alpha Lipoic Acid
5000 KG Dec 20, 2024
India
Alpha Lipoic Acid
500.00 KG Jun 28, 2024
India
ALPHA LIPOIC ACID
200 KG Nov 22, 2024
India
Factory Price Alpha Lipoic Acid ALA 99% from China
500 MT Oct 22, 2023 Post an enquiry for this product
