Amlodipine Besilate 100%

Amlodipine Besilate More Info

What it is:

Amlodipine Besilate, also known as Benazepril Besylate, is a dihydropyridine calcium channel blocker. It works by inhibiting the transmembrane entry of calcium ions into vascular smooth muscle and cardiac muscle cells, thereby dilating blood vessels and reducing blood pressure. This medication is commonly used for the treatment of hypertension and angina.

Uses:

- Hypertension: Amlodipine Besilate can be used alone or in combination with other antihypertensive drugs to lower blood pressure to normal levels.

- Angina: The drug is also used to treat chronic stable angina or vasospastic angina. By dilating the coronary arteries, it increases the oxygen supply to the heart muscle, thereby relieving angina symptoms.

Precautions:

1. Contraindications: Patients who are allergic to Amlodipine Besilate or other calcium channel blockers should not use this medication.

2. Warnings: Especially for patients with severe coronary artery obstructive disease, the use of calcium antagonists may lead to an increase in the frequency, duration, and severity of angina, or the occurrence of acute myocardial infarction when starting treatment or increasing the dose.

3. Use in heart failure patients: The use of calcium antagonists in patients with congestive heart failure should be cautious.

4. Use in patients with liver damage: Like all calcium antagonists, the half-life of Amlodipine Besilate is prolonged in patients with liver damage, so it should be used with caution.

5. Use in patients with renal failure: The change in plasma concentration of this drug is not related to the degree of renal impairment, so a normal dose can be used.

6. Elderly patients: The medication should be used with caution in elderly patients, and the initial dose may need to be lower.

7. Drug interactions: Amlodipine Besilate may interact with other drugs, such as CYP3A4 inhibitors and inducers, so caution should be exercised when used in combination.

Summary:

Amlodipine Besilate is an effective antihypertensive and angina drug that lowers blood pressure and relieves angina by blocking calcium channels. However, it has some contraindications and precautions, especially for patients with specific heart diseases and impaired liver and kidney function. When using, it should be followed under the guidance of a physician and attention should be paid to possible drug interactions.