API Rocuronium bromide

Name	Rocuronium Bromide
CAS number	119302-91-9
Synonym	Rocuronium Bromide; Rocuronium Br; Zemuron; Rocuronium (Bromide); Esmeron; UNII-I65MW4OFHZ; Esmeron; Esmerone; ORG 9426 ;ORG-9426;
Related CAS	143558-00-3 (free base); 119302-91-9 (bromide)
Description	Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. It is used for both standard and rapid sequence induction (RSI).
Structure
Molecular Formula	C32H53BrN2O4
Molecular Weight	609.680
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Rocuronium Bromide More Info

Rocuronium Bromide is a non - depolarizing neuromuscular - blocking agent.

1. Chemical characteristics

Chemically, it is a bis - ammonium steroid compound. The molecular formula is C₃₂H₅₃BrN₂O₄, and its molecular weight is about 609.7 g/mol.

2. Mechanism of action

It acts at the neuromuscular junction. Specifically, it competes with acetylcholine for binding sites on the nicotinic acetylcholine receptors on the motor end - plate of the skeletal muscle. By binding to these receptors, it blocks the normal depolarization process that is usually induced by acetylcholine, thereby preventing muscle contraction and leading to muscle relaxation. This is a reversible process, and as the concentration of the drug decreases, the normal function of the neuromuscular junction can be restored.

3. Pharmacokinetics

Onset of action: Rocuronium bromide has a relatively rapid onset of action. It can produce neuromuscular blockade within 1 - 2 minutes after intravenous injection, which makes it suitable for rapid sequence induction of anesthesia, for example, in situations such as emergency intubation to secure the airway quickly and prevent aspiration.

Duration of action: The duration of its neuromuscular - blocking effect is dose - dependent. At normal therapeutic doses, the muscle relaxation effect usually lasts for about 30 - 60 minutes. After the drug is administered, it is distributed in the extracellular fluid and then metabolized and excreted. A portion of it is eliminated through the liver by hepatic metabolism, and the metabolites are excreted through the bile. Another part is excreted unchanged through the kidneys.

4. Clinical uses

Anesthesia - related procedures: It is widely used in surgical anesthesia to provide muscle relaxation during operations. This helps the surgeon to have better access to the surgical field and perform procedures more easily. For example, in abdominal surgeries, muscle relaxation allows for better exposure of the internal organs and reduces the resistance that the surgeon encounters during tissue manipulation.

Intubation: As mentioned before, due to its relatively fast onset, it is a valuable drug for tracheal intubation. It enables the anesthesiologist to quickly and smoothly insert the endotracheal tube into the trachea, ensuring proper ventilation during surgery and other procedures that require airway management.

5. Side effects and precautions

Side effects: Common side effects may include hypotension (low blood pressure) and tachycardia (rapid heart rate) in some cases. There is also a risk of residual neuromuscular blockade after the use of the drug, which can lead to muscle weakness and respiratory problems if not properly reversed. Prolonged muscle relaxation can cause patient discomfort and an increased risk of complications such as pressure sores due to immobility.

Precautions: Special attention should be paid to patients with impaired hepatic or renal function because the drug's metabolism and excretion may be affected. Dosage adjustments may be necessary in such patients. Additionally, appropriate monitoring of neuromuscular function during and after the use of rocuronium bromide is essential to ensure timely reversal of the muscle - relaxing effect and to avoid potential complications related to over - relaxation.