China Professional Factory YI Hang Supply High Quality 99% Yellowish-brown Powder Retinal CAS No.:116-31-4

Essential information

Molecular formula: C20H28O

Molecular weight: 284.44

Physical property

Melting point: 61-63°C

Boiling point: 366.92°C (rough estimate)

Density: 1.0083 (rough estimate)

Refractive index: 1.4500 (estimate)

Storage condition: -20°C

Solubility: Soluble in chloroform (a little), ethyl acetate (a little), and methanol (a little). <70mg/L(25 ºC) in water

Stability: Hygroscopicity, photosensitivity, thermosensitivity

InChI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

InChIKey: NCYCYZXNIZJOKI-OVSJKPMPSA-N

SMILES: C(=O)/C=C(/C=C/C=C(/C=C/C1C(C)(C)CCCC=1C)\C)\C

EINECS: 204-135-8

Introduction
Vitamin A aldehyde, also known as retinal, is the closest component to all-trans retinoic acid. It is generated by the oxidation and cleavage of β-carotene. Reduction yields retinol, and oxidation yields retinoic acid. Retinal is the coenzyme of rhodopsin. Within visual cells, 11-cis retinal and opsin form visual pigments. After absorbing light, 11-cis retinal is isomerized to all-trans retinal, which causes a conformational change in rhodopsin and initiates neural impulses to the brain, thereby forming vision.

Chemical prpoerty

There are 16 stereoisomers. 13 of them have been chemically synthesized, among which the 11-trans isomer is the chromophore in natural opsins. All E-type: crystalline. Melting point 64-65℃. 7E, 9Z, 11E, 13E types: melting point 56-58℃.

Purpose

The intermediate of β-carotene.

Function
Retinaldehyde is an important signal transduction molecule in the development of the eye. It plays various significant roles in the development of the eye in vertebrates. Myopia is a developmental disorder. The active expansion of the sclera of the myopic eye is an important mechanism for its elongation. Retinaldehyde may be a messenger molecule regulating the elongation of experimental myopic eyes. Studies on the relationship between retinaldehyde and the occurrence and development of experimental myopia have made certain progress. This study reviews the progress in the research on retinaldehyde and its nuclear receptors, retinaldehyde changes in the retina, choroid, and sclera of experimental myopic eyes, and retinaldehyde as a messenger molecule transmitting the elongation signal from the retina to the sclera in the eye. Retinoic acid has a very wide range of effects in dermatological diseases. However, due to local irritation, its clinical application is somewhat limited. Retinaldehyde is an intermediate metabolite of natural retinoic acid and has similar biological activities to retinoic acid. Moreover, the skin has a significantly better tolerance to it than retinoic acid. This article reviews the metabolism and biological activities of retinaldehyde in the body and in the skin, as well as its application in dermatology. Although quitting smoking can significantly reduce the risk of lung cancer, for those who have quit smoking for 20 years, their risk of developing this cancer is still twice as high as that of non-smokers. The research results of American experts show that for such quitters, taking an appropriate amount of retinaldehyde (i.e., derivatives of vitamin A retinol and retinoic acid) daily can further effectively reduce the possibility of developing lung cancer. Relevant research reports were recently published in the Journal of the American College of Cancer Research. Dr. Jonathan M. Kurie, a medical doctor from the M.D. Anderson Cancer Research Center of the University of Texas, and others conducted this study comparing the effects of two different retinal aldehydes on the retinoic acid beta receptor (RARbeta) in the lung tissues of 226 quitters. This receptor's reduction is usually considered a precursor to the occurrence of pre-cancerous tumors. At the beginning of the experiment, about 60% of the volunteers had a reduction in RARbeta receptor numbers. After taking 9-cisRA retinaldehyde for three months (twice a day), it was found that the number of RARbeta receptors in this group of volunteers increased significantly, but those who took another retinaldehyde showed no significant difference from the ineffective control group. In addition, experts also believe that the effects of retinaldehyde may be different for those who are still smoking.

Packaging Details: 25 kg/bag or as your requirement.
Port: Tianjin/ Qingdao/ Shanghai, etc.
We can ship the samples by air.
Lead Time: Within 2-3days after receiving the advance payment or original L/C.

XI'AN YI HANG CHEMICAL CO.,LTD was founded in 2002, located in xian City, shannxi, China. We are the high-tech chemical enterprise which specialized in researching, manufacturing and trading for chemical raw materials ,our products widely used in paints, textile, rubber, leather, plastic and so on.

With many years development and operation,we have become the group company for chemical production,we have the owned factory for produce stable quality products with high performance, and the advanced lab to ensure the best quality of each batch products.

We have our strictly quality control in our production, and we have passed ISO9001:2015 Quality Management System Certification and ISO14001 Environment Management System Certification.

Our main products includes Titanium Dioxide, Lithopone, Iron Oxide series, Chrome Oxide Green, Zinc Oxide, Carbon Black, STPP, SHMP, Oxalic Acid, DOP, SLES, and so on.

Q1: Are you manufacturer or trading company?

A1:Manufacturer.

Q2: Can I get some sample?
A2: Yes, usually 10-25g sample for free.

Q3: Is there a discount?
A3: Of course, welcome to contact us. Price would be different based on different quantity. For bulk
quantity, we will have discount for you.

Q4: How long for production and delivery?
A4: Most products we have in stock, sent time:Within 1-3 business days after received payment. Customized products further discussed.

Q5: Do you accept ODM or OEM service?
A5: Yes,we accept ODM and OEM services, ranges: Soft gel, Capsule, Tablet, Sachet, Granule,Private Label service, etc. Please contact us to design your own brand product.

Q6: How to deliver the goods?
A6: ≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.

Q7: How to start orders or make payments?
A7:There are two ways for you to confirm order:
1. Proforma invoice with our company bank details will be sent to you once the order confirmed by Email. Pls arrange payment by  TT. Goods will be sent after received payment within 1-3 business days.
2. Trade assurance order will be drafted for you through ALIBABA. Pls confirm and pay through Alibaba. Goods will be sent after  received payment within 1-3 business days.