Piperine Powder Raw Material Piperine Price Pure Black Pepper Extract Piperine

I. Overview

Piperine, chemically known as 5-(1,3-benzodioxol-5-yl)-1-piperidin-1-yl-2,4-pentadien-1-one, is a bioactive alkaloid extracted from plants such as black pepper (Piper nigrum) and long pepper (Piper longum). It exists as a white to pale yellow crystalline powder with a pungent taste, and is the primary source of the characteristic aroma and spiciness of pepper.

Chemical Properties:

• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 285.34 g/mol
• Melting Point: 130–133°C
• Solubility: Sparingly soluble in water, soluble in ethanol, ether, chloroform, and other organic solvents

Biological Activities:

• Enhancement of Bioavailability: Piperine inhibits intestinal glucosidases and cytochrome P450 enzymes, slowing drug metabolism and increasing the absorption and bioavailability of co-administered drugs.
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• Antioxidant and Anti-inflammatory Effects: Scavenges free radicals, reduces oxidative stress, and inhibits inflammatory responses.
• Neuroprotective Effects: Modulates neurotransmitter levels and may offer protection against neurological disorders.
• Antitumor Effects: Induces apoptosis in tumor cells and inhibits tumor growth and metastasis.

II. Applications

1. Pharmaceutical Field

   • Improvement of Drug Efficacy: Used as a bioavailability enhancer, piperine is often co-administered with drugs like curcumin and silymarin to significantly increase their absorption and efficacy. For example, its combination with curcumin can enhance curcumin's bioavailability by up to 2000%.
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   • Treatment of Digestive Disorders: Used for managing dyspepsia, gastric ulcers, and other digestive conditions by promoting the secretion of digestive juices and enhancing gastrointestinal motility.
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   • Neurological Disorders: Exhibits antidepressant, anticonvulsant, and analgesic properties, potentially aiding in the management of epilepsy, depression, and other neurological conditions.
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   • Antitumor Therapy: Serves as an adjuvant to enhance the efficacy of chemotherapeutic agents and mitigate their side effects.
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2. Food and Nutraceuticals

   • Flavoring Agent: Imparts a spicy flavor and aroma to food products and is widely used in seasonings, spices, and food additives.
   • Dietary Supplements: Used as a supplement to enhance the absorption of nutrients and boost immunity.
   • Functional Foods: Developed into health foods with antioxidant, anti-inflammatory, and anti-fatigue properties.
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3. Agricultural Field

   • Biopesticides: Possesses insecticidal, fungicidal, and repellent properties, making it a viable natural pesticide for organic farming.
   • Plant Growth Regulators: Promotes plant growth and enhances crop yield and quality.
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4. Cosmetics

   • Antioxidant: Incorporated into skincare products to protect the skin from free radical damage and delay aging.
   • Skin Whitening Agent: Inhibits melanin production, offering skin-lightening and spot-reducing effects.