99% High Qulity Methylcobalamin VB(12) Mecobalamin CAS 13422-55-4

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Methylcobalamin, also known as methyl vitamin B12, can promote the synthesis of nucleic acids and proteins in nerve cells, repair damaged nerve cells, improve nerve conduction velocity, and is widely used in the treatment of clinical peripheral neuropathy and other diseases.

Mechanism of Action

Mecobalamin is a derivative of vitamin B12. According to its chemical structure nomenclature, it should be called "methyl vitamin B12." Its methylated functional group can participate in methyl transfer processes in biochemical activities, promoting nucleic acid, protein, and lipid metabolism in nerve tissue. It stimulates lecithin synthesis in Schwann cells, repairs damaged myelin sheaths, and improves nerve conduction velocity. Mecobalamin can directly enter nerve cells and promote regeneration in damaged axon regions. It also stimulates protein synthesis in nerve cells, enhances anabolic metabolism in axons, and prevents axonal degeneration. Additionally, it participates in nucleic acid synthesis and boosts hematopoietic function.

Clinically, it is commonly used to treat diabetic neuropathy, and long-term use has shown certain efficacy in managing macrovascular complications of diabetes. Mecobalamin is primarily indicated for peripheral neuropathy caused by diabetes and megaloblastic anemia due to vitamin B12 deficiency. It is widely used in clinical practice with minimal side effects.

Indications

Mecobalamin is one of the four members of the vitamin B12 family and one of the two active coenzyme forms of vitamin B12 in the body (the other being adenosylcobalamin). It plays a crucial role in the synthesis and metabolism of nucleic acids in brain cells and peripheral nerve cells, as well as in the utilization of folic acid, making it essential for the nervous system.

Preparation

All existing synthetic methods for mecobalamin involve a two-step process of cyanocobalamin reduction followed by methylation, which is typically performed as a one-pot reaction. Common synthetic approaches include:

Sodium borohydride reduction of cyanocobalamin followed by methylation with iodomethane.

Sodium borohydride reduction of cyanocobalamin followed by methylation with dimethyl sulfate.

Sodium borohydride reduction of cyanocobalamin followed by methylation with methyl p-toluenesulfonate.

Sodium borohydride reduction of cyanocobalamin in the presence of cobalt or iron salts, followed by methylation with trimethylsulfoxonium iodide or trimethylsulfoxonium bromide.

Sodium borohydride reduction of cyanocobalamin followed by methylation with dimethyl carbonate.

Side Effects and Precautions

Common side effects:

Nausea ； Diarrhea ； Headache ； Dizziness ； Serious side effects (rare): ； Allergic reaction (rash, itching, swelling) ； Chest pain ； Shortness of breath

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