High Purity Tanning Peptide Melanotan II Melanotan 2 Mt2 CAS 121062 08 6 Raw Material

Melanotan II More Info

Chemical Profile and Structural Characteristics

Melanotan II (CAS 121062-08-6) is a synthetic cyclic heptapeptide with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. This analog of α-melanocyte-stimulating hormone (α-MSH) features a lactam bridge between the aspartic acid and lysine residues, which confers enhanced metabolic stability and receptor binding affinity compared to linear peptides. The incorporation of norleucine (Nle) in place of  further improves oxidative stability, while the D-phenylalanine configuration increases resistance to enzymatic degradation.

Mechanism of Action and Biological Activity

Melanotan II functions as a non-selective agonist of melanocortin receptors, with particularly high affinity for MC1R, MC3R, MC4R, and MC5R subtypes. Activation of MC1R in skin melanocytes stimulates melanogenesis and pigment dispersion, leading to skin darkening. Simultaneously, its activity at MC4R in the central nervous system contributes to appetite suppression and potential effects on sexual function. The compound's ability to cross the blood-brain barrier enables both central and peripheral actions, though this also contributes to its side effect profile.

Research Applications and Investigational Uses

In scientific research, Melanotan II serves as a valuable tool compound for studying melanocortin receptor signaling and function. Preclinical investigations have explored its potential in photoprotection against UV radiation, with studies demonstrating reduced DNA damage in melanized skin. Additional research applications include the study of feeding behavior, energy homeostasis, and sexual dysfunction. The compound has also been utilized in dermatological research focused on pigmentary disorders and inflammation modulation.

Formulation Challenges and Delivery Considerations

The peptide nature of Melanotan II presents significant formulation challenges, including susceptibility to enzymatic degradation and limited oral bioavailability. Research formulations typically employ subcutaneous or intramuscular routes to ensure adequate systemic exposure. Our technical support includes guidance on peptide handling, solubility optimization in aqueous buffers, and sterile preparation techniques for in vivo studies. Stability data supports storage as a lyophilized powder at -20°C for long-term preservation.

Quality Specifications and Analytical Characterization

We supply Melanotan II with comprehensive analytical documentation, including HPLC purity ≥95%, mass spectrometry confirmation of molecular weight (1024.2 Da), and amino acid analysis verification. Critical quality attributes include peptide content, chiral purity assessment, and  of deletion sequences and oxidative byproducts. Our quality control employs reversed-phase HPLC with UV detection and characterization by LC-MS to ensure identity, purity, and batch-to-batch consistency for research applications.

Safety Profile and Toxicity Considerations

Preclinical studies have reported dose-dependent adverse effects including nausea, facial flushing, yawning, and spontaneous penile erections. Chronic administration studies indicate potential hyperpigmentation and melanocytic hyperplasia concerns. The compound has not undergone comprehensive clinical safety evaluation for human therapeutic use. Researchers should implement appropriate safety protocols for handling and administration, with particular attention to dose calculation accuracy and physiological monitoring in animal studies.

Stability Profile and Storage Requirements

Melanotan II demonstrates optimal stability as a lyophilized powder when stored at -20°C in sealed containers protected from light and moisture. Under these conditions, the peptide maintains chemical integrity for extended periods. Reconstituted solutions in sterile water or bacteriostatic water should be used immediately or stored at 2-8°C for limited periods with stability not exceeding 24 hours. Long-term stability data supports proper storage practices to prevent degradation and maintain biological activity.

Regulatory Status and Compliance Information

Melanotan II is an investigational compound not approved for human therapeutic use by major regulatory agencies including the FDA and EMA. Our material is supplied for research purposes only, in compliance with applicable controlled substance regulations and research guidelines. We provide necessary documentation to support legitimate research applications while emphasizing adherence to ethical research practices and institutional review requirements.

Market Position and Research Utility

Within the research chemicals market, Melanotan II occupies a specialized niche for studying melanocortin biology and related physiological processes. Demand is driven by academic institutions, pharmaceutical research departments, and contract research organizations investigating melanocortin receptor therapeutics. The compound's unique pharmacological profile continues to make it a valuable tool for basic research despite the development of more receptor-selective analogs.

Technical Support and Research Collaboration

We provide comprehensive technical support including peptide handling protocols, solubility guidance, and experimental design consultation. Our scientific team offers assistance with analytical method development, formulation strategies, and interpretation of research results. We welcome collaborative opportunities to advance understanding of melanocortin biology and support responsible research applications of this unique peptide compound.

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