99% Top Quality D-α-Tocopherol succinate CAS 4345-03-3 White Raw Power With Best Price

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Chemical Profile and Structural Characteristics

D-α-Tocopherol succinate (CAS 4345-03-3) is a semi-synthetic ester derivative of natural vitamin E, formed through the esterification of the phenolic hydroxyl group of D-α-tocopherol with succinic anhydride. This molecular modification creates a compound with enhanced stability against oxidation while maintaining the biological activity of vitamin E upon hydrolysis in the body. The compound presents as a white to off-white crystalline powder or granules with a molecular weight of 530.8 g/mol. It demonstrates lipophilic character with solubility in oils and organic solvents but limited solubility in aqueous systems, characteristics that significantly influence its formulation and absorption properties.

Biochemical Functions and Mechanism of Action

The compound functions as a stable precursor to active vitamin E, undergoing enzymatic hydrolysis in the intestinal lumen and tissues to release D-α-tocopherol and succinate. The liberated tocopherol then exerts its primary biological activity as a chain-breaking antioxidant that protects polyunsaturated fatty acids in membranes and plasma lipoproteins from peroxidation. Additional mechanisms include modulation of cell signaling pathways, gene expression regulation, and inhibition of protein kinase C activity. The succinate moiety may contribute independent biological effects including potential influences on cellular energy metabolism and apoptosis regulation in certain experimental systems.

Therapeutic Applications and Nutritional Uses

D-α-Tocopherol succinate is widely utilized in pharmaceutical formulations and dietary supplements for vitamin E supplementation, particularly in applications requiring enhanced stability. Clinical applications include management of vitamin E deficiency states, neurological conditions involving oxidative stress, and as an adjunct in cardiovascular health support. The compound is particularly valuable in solid dosage forms and multi-vitamin preparations where oxidative stability is crucial for product shelf life. Typical supplemental doses range from 100-400 IU daily, with higher doses employed in specific clinical circumstances under medical supervision.

Formulation Advantages and Stability Profile

The succinate ester form provides significant formulation advantages including superior stability against oxidation during manufacturing and storage compared to unesterified tocopherol. This enhanced stability allows for direct compression tableting, longer shelf life, and better compatibility with other ingredients including minerals and other vitamins. Technical data supports its use in various delivery systems including dry powder capsules, tablets, and softgel formulations. The compound maintains excellent chemical integrity under standard manufacturing conditions and demonstrates consistent dissolution characteristics in gastrointestinal simulated fluids.

Quality Specifications and Analytical Standards

Our D-α-Tocopherol succinate meets stringent quality specifications including identification by HPLC and IR spectroscopy, assay requirement of 96.0-102.0%, and of related substances including free tocopherol, other tocopherol isomers, and succinate-related impurities. Critical quality parameters encompass tests for heavy metals, residual solvents, microbial limits, and specific optical rotation to verify the natural D-isomer configuration. We employ validated stability-indicating HPLC methods with fluorescence detection for precise quantification and monitoring of hydrolysis products, ensuring consistent quality and biological activity throughout the product lifecycle under recommended storage conditions.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.