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2-Fluorobenzoyl chloride 393-52-2

Name: 2-Fluorobenzoyl chloride 393-52-2
Brand: Orient
SKU: pr2511271578
Price: 2 USD
Availability: InStock

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CAS No.:

393-52-2

Grade:

Industrial Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-27

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Description

2-Fluorobenzoyl chloride Chemical Properties

Melting point	4 °C (lit.)
Boiling point	90-92 °C/15 mmHg (lit.)
density	1.328 g/mL at 25 °C (lit.)
refractive index	n20/D 1.536(lit.)
Fp	180 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly)
form	Liquid
color	Clear colorless to faintly colored
Specific Gravity	1.328
Water Solubility	Decomposition
Sensitive	Lachrymatory
BRN	636864
CAS DataBase Reference	393-52-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzoyl chloride, 2-fluoro-(393-52-2)
EPA Substance Registry System	o-Fluorobenzoyl chloride (393-52-2)

2-Fluorobenzoyl chloride Usage And Synthesis

Chemical Properties	clear colorless to faintly colored liquid
Uses	2-Fluorobenzoyl Chloride (cas# 393-52-2) is a compound useful in organic synthesis.
Uses	2-Fluorobenzoyl chloride has been used in the preparation of 3-(N-Hydroxycarbamimidoyl)-benzoic acid methyl ester. It has been used to develop an hollow-fiber liquid phase microextraction with in situ derivatization method coupled with HPLC-UV for the determination of metformin hydrochloride in biological fluids.
General Description	Colorless liquid.
Air & Water Reactions	Decomposes in water to form HCl with generation of heat
Reactivity Profile	2-Fluorobenzoyl chloride is sensitive to moisture. Incompatible with water, alcohol, bases (including amines) and with oxidizing agents . May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Fire Hazard	2-Fluorobenzoyl chloride is combustible.
Synthesis	445-29-4 393-52-2 Step I Synthesis of 2-fluorobenzoyl chloride (intermediate a): 0.714 mol (100 g) of 2-fluorobenzoic acid was added to 100 mL of toluene, and the mixture was heated to 50 °C before 5.7 mol (414 mL) of sulfoxide chloride was added slowly. The reaction mixture was reacted under reflux conditions for 7 hours. Upon completion of the reaction, the excess sulfoxide chloride was removed by evaporation to give 79 g of 2-fluorobenzoyl chloride in 70% yield.
References	[1] Phosphorus, Sulfur and Silicon and Related Elements, 1996, vol. 113, # 1-4, p. 179 - 207 [2] Journal of Organometallic Chemistry, 2005, vol. 690, # 17, p. 3918 - 3928 [3] Organic and Biomolecular Chemistry, 2009, vol. 7, # 23, p. 4886 - 4894 [4] Patent: EP2799437, 2014, A1. Location in patent: Paragraph 0055 [5] Patent: US2014/364431, 2014, A1. Location in patent: Paragraph 0186

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A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

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Certificates

Basic Info

Product Name:

2-Fluorobenzoyl chloride

Other Name:

Benzoyl chloride,2-fluoro-;Benzoyl chloride,o-fluoro-;2-Fluorobenzoyl chloride;o-Fluorobenzoyl chloride;NSC 88304;2-Fluorobenzenecarbonyl chloride

CAS No.:

393-52-2

Molecular Formula:

C7H4ClFO

InChIKeys:

InChIKey=RAAGZOYMEQDCTD-UHFFFAOYSA-N

Molecular Weight:

158.55700

Exact Mass:

158.56

EC Number:

206-887-2

UNII:

Z4H017N76S

NSC Number:

88304

UN Number:

1760

DSSTox ID:

DTXSID3025330

Color/Form:

Liquid

HScode:

29163900

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

17.07000

XLogP3:

2.8

Appearance:

2-fluorobenzoyl chloride is a colorless liquid. (NTP, 1992)

Density:

1.304

Melting Point:

4 °C

Boiling Point:

204 °C

Flash Point:

82ºC

Refractive Index:

1.5355-1.5375

Water Solubility:

Decomposes (NTP, 1992)

Storage Conditions:

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool

Vapor Pressure:

0.46 mm Hg at 25 deg C (est)

Henrys Law Constant:

Henry's Law constant = 1.5X10-4 atm-cu m/mol at 25 °C (est)

Experimental Properties:

Hydroxyl radical reaction rate constant = 2.2X10-12 cu cm/molecule-sec at 25 °C (est)

Air and Water Reactions:

Decomposes in water to form HCl with generation of heat (NTP, 1992)

Reactive Group:

Acyl Halides, Sulfonyl Halides, and Chloroformates

Reactivity Alerts:

Water-Reactive

Reactivity Profile:

2-FLUOROBENZOYL CHLORIDE is sensitive to moisture. Incompatible with water, alcohol, bases (including amines) and with oxidizing agents (NTP, 1992). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

See More 2-Fluorobenzoyl chloride Properties 

Hazard Identification

Classification of the substance or mixture

Skin corrosion, Sub-category 1B

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H314 Causes severe skin burns and eye damage H335 May cause respiratory irritation
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2-Fluorobenzoyl chloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
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2-Fluorobenzoyl chloride 393-52-2

Product Description

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