DIETHYL BROMOMALONATE 685-87-0

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The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

DIETHYL BROMOMALONATE Basic information Product Name: DIETHYL BROMOMALONATE Synonyms: alpha-Bromomalonic ester;bromo-propanedioicacidiethylester;Diethyl 2-bromomalonate;Diethyl alpha-bromomalonate;Malonic acid, bromo-, diethyl ester;ETHYL BROMOMALONATE;DIETHYL BROMOMALONATE;BROMO DIETHYL MALONATE CAS: 685-87-0 MF: C7H11BrO4 MW: 239.06 EINECS: 211-683-1 Product Categories: Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;C6 to C7;Carbonyl Compounds;Esters;bc0001 Mol File: 685-87-0.mol DIETHYL BROMOMALONATE Chemical Properties Melting point  -54°C Boiling point  233-235 °C (lit.) density  1.402 g/mL at 25 °C (lit.) refractive index  n20/D 1.451(lit.) Fp  >230 °F storage temp.  under inert gas (nitrogen or Argon) at 2-8°C solubility  Chloroform, Hexanes pka 9.29±0.46(Predicted) form  Liquid color  Clear colorless to slightly yellow Specific Gravity 1.402 Water Solubility  Does not mix well with water. Sensitive  Lachrymatory BRN  509768 CAS DataBase Reference 685-87-0(CAS DataBase Reference) EPA Substance Registry System Propanedioic acid, 2-bromo-, 1,3-diethyl ester (685-87-0) Safety Information Hazard Codes  C Risk Statements  34 Safety Statements  26-36/37/39-45 RIDADR  UN 3265 8/PG 2 WGK Germany  3 F  19 Hazard Note  Corrosive/Lachrymator TSCA  Yes HazardClass  8 PackingGroup  III HS Code  29171900 DIETHYL BROMOMALONATE Usage And Synthesis Chemical Properties CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID Uses Diethyl Bromomalonate is a chemical constituent of the asymmetric cyclopropanation of chalcones. Also used in the preparation of nanaplatforms for NIR imaging-guided photodynamic therapy of cancer cel ls. Uses Diethyl bromomalonate is used in perfumes. It is also used to synthesize other compounds such as barbiturates, artificial flavorings, vitamin B1, and vitamin B6. Synthesis The Preparative Method of Diethyl Bromomalonate: by light-induced bromination of Diethyl Malonate with bromine in carbon tetrachloride; by treatment of diethyl malonate with bromotrichloromethane and 1,8-Diazabicyclo[5.4.0]undec-7-ene in benzene at 0 °C. Purification Methods Purify the ester by fractional distillation in a vacuum. IR: max 1800 and 1700cm-1 [Abramovitch Can J Chem 37 1146 1959, Bretschneider & Karpitschka Monatsh Chem 84 1091 1053]. [Beilstein 2 IV 1904.] References [1] Tetrahedron, 1983, vol. 39, # 21, p. 3493 - 3505 [2] RSC Advances, 2017, vol. 7, # 87, p. 55434 - 55440 [3] Bulletin de la Societe Chimique de France, 1986, # 6, p. 881 - 884 [4] Synthesis, 1980, # 2, p. 143 - 146 [5] Journal of Fluorine Chemistry, 2005, vol. 126, # 11-12, p. 1487 - 1492 DIETHYL BROMOMALONATE Preparation Products And Raw materials Raw materials Ethyl acetate-->Tetrahydrofuran-->PETROLEUM ETHER-->Sodium carbonate-->Bromine-->Carbon tetrachloride-->Diethyl malonate Preparation Products 3-Methylbenzofuran-2-carboxylic acid-->Benzofuran-2-carboxylic acid-->5-METHOXYBENZOFURAN-2-BORONIC ACID-->2-ETHOXYCARBONYL-3-COUMARANONE-->1-Oxo-1H-isochromene-3-carboxylic Acid-->Diethyl allylmalonate-->ETHYL 5-NITROBENZOFURAN-2-CARBOXYLATE-->Diethyl chloromalonate-->5-NITROBENZOFURAN-2-CARBOXYLIC ACID-->ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE-->Ethyl 4-hydroxy-2-(pyridin-3-yl)thiazole-5-carboxylate-->ETHYL 4-HYDROXY-2-(4-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXYLATE



——  Q&A  ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.