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Trometamol77-86-1

Name: Trometamol77-86-1
Brand: Orient
SKU: pr2511281649
Price: 5 USD
Availability: InStock

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CAS No.:

77-86-1

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-28

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Tris(hydroxymethyl)aminomethane Basic information

Product Name:	Trometamol
Synonyms:	Trometamol
CAS:	77-86-1
MF:	C4H11NO3
MW:	121.14
EINECS:	201-064-4
Product Categories:	tris;Pharmaceutical intermediates;API;ACS Grade Buffers;Amino Alcohols;Biological Buffers;Buffers A to Z;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Buffer;Biochemistry;Reagents for Electrophoresis;bc0001;77-86-1
Mol File:	77-86-1.mol

Tris(hydroxymethyl)aminomethane Chemical Properties

Melting point	167-172 °C(lit.)
Boiling point	219-220 °C10 mm Hg(lit.)
bulk density	840kg/m3
density	1,353 g/cm³
vapor pressure	0.0267 hPa (20 °C)
refractive index	1.4170 (estimate)
Fp	219-220°C/10mm
storage temp.	20-25°C
solubility	H₂O: 4 M at 20 °C, clear, colorless
form	crystalline
color	white
PH	10.5-12.0(4 m in water, 25 °C)
PH Range	7 - 9
pka	8.1(at 25℃)
biological source	synthetic
Water Solubility	550 g/L (25 ºC)
λmax	λ: 260 nm Amax: 0.10 λ: 280 nm Amax: 0.08
Sensitive	Hygroscopic
Merck	14,9772
BRN	741883
Stability:	Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
InChIKey	LENZDBCJOHFCAS-UHFFFAOYSA-N
LogP	-2.515 (est)
CAS DataBase Reference	77-86-1(CAS DataBase Reference)
NIST Chemistry Reference	1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry System	Tris(hydroxymethyl)aminomethane (77-86-1)
Absorption	passes test

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39-24/25-23
WGK Germany	2
RTECS	TY2900000
F	3
TSCA	Yes
HazardClass	IRRITANT
HS Code	29221980
Hazardous Substances Data	77-86-1(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rat > 5000 mg/kg

Tris Usage And Synthesis

description	Tris, , or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology as a component of buffer solutions such as in TAE and TBE buffers, especially for solutions of nucleic acids. It contains a primary amine and thus undergoes the reactions associated with typical amines, e.g. condensations with aldehydes. Tris also complexes with metal ions in solution. In medicine, tromethamine is occasionally used as a drug, given in intensive care for its properties as a buffer for the treatment of severe metabolic acidosis in specific circumstances. Some medications are formulated as the "tromethamine salt" including hemabate (carboprost as trometamol salt), and "ketorolac trometamol".
Chemical Properties	Tris is a white crystal or powder. The melting point is 171-172℃ and the boiling point of Tris is 219-220℃/1.3kPa. It is soluble in ethanol and water, slightly soluble in ethyl acetate and benzene, and insoluble in ether and carbon tetrachloride. It has a corrosive effect on copper and aluminum and has strong irritation.
Uses of Biology	Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pK_a of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.
Uses	1, Tris buffer, only nucleic acids and proteins are widely used as solvents. 2, Tris is used for protein crystal growth under different pH conditions. 3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers. 4, Tris is a major component of protein electrophoresis buffer. 5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates. 6, Tris titrated also used as standard.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Tris(hydroxymethyl)aminomethane

Other Name:

1,3-Propanediol,2-amino-2-(hydroxymethyl)-;2-Amino-2-(hydroxymethyl)-1,3-propanediol;2-Amino-2-(hydroxymethyl)propane-1,3-diol;Aminotris(hydroxymethyl)methane;Talatrol;THAM;Trimethylolaminomethane;Tris;Trisamine;Tris buffer;Tris(hydroxymethyl)methylamine;Trizma;Trometamol;Tromethamine;2-Amino-2-methylol-1,3-propanediol;Tris(hydroxymethyl)aminomethane;Methanamine,1,1,1-tris(hydroxymethyl)-;Aminotrimethylolmethane;Trometamole;Tromethane;Tris Amino;Tris-steril;Tris(hydroxymethyl)methanamine;Pehanorm;Tutofusin tris;Trisamin;Tromethanmin;Addex-Tham;Trisaminol;Tris (buffering agent);Triladyl;Tris(methylolamino)methane;Trigmo base;TAM;Aminotri(hydroxymethyl)methane;Tris Amino Crystal;TAM (buffering agent);NSC 103026;NSC 6365;NSC 65434;Tri(hydroxymethyl)methylamine;Tri Amino;2-Amino-1,3-dihydroxy-2-(hydroxymethyl)propane;2-Amino-2-hydroxymethylpropan-1,3-diol;[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]amine;Tris base;Tri(hydroxymethyl)aminomethane;Trizma Base;Ricrolin TE;A 0321;2-Amino-2-(hydroxymethyl)propanediol;1,3-Dihydroxy-2-(hydroxymethyl)propan-2-amine;Tris Amino Ultra PC (J) tromethamine;Tris Amino Ultra;Toris Amino Ultra PC;T 1503;108195-86-4;119320-15-9;25149-07-9;68755-45-3;83147-39-1;857365-23-2;1158650-64-6

CAS No.:

77-86-1

Molecular Formula:

C4H11NO3

InChIKeys:

InChIKey=LENZDBCJOHFCAS-UHFFFAOYSA-N

Molecular Weight:

121.13500

Exact Mass:

121.14

EC Number:

201-064-4

UNII:

023C2WHX2V

NSC Number:

65434|6365

DSSTox ID:

DTXSID2023723

Color/Form:

Crystalline mass|WHITE, CRYSTALLINE POWDER

ATC Code:

B - Blood and blood forming organs

HScode:

29221980

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

86.71000

XLogP3:

-2.9

Appearance:

Liquid

Density:

0.6181 g/cm³ @ Temp: 25 °C

Melting Point:

171-172 °C

Boiling Point:

219-220 °C @ Press: 10 Torr

Flash Point:

100ºC

Refractive Index:

1.531

Water Solubility:

H2O: 550 g/L (25 ºC)

Storage Conditions:

2-8ºC

Vapor Pressure:

0.0267 hPa (20 °C)

Toxicity:

LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rat > 5000 mg/kg

Odor:

SLIGHT, CHARACTERISTIC ODOR

Taste:

FAINT, SWEET, SOAPY TASTE

PH:

pH of 0.1 molar aq soln = 10.4

Henrys Law Constant:

Henry's Law constant = 8.7X10-13 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa = 8.07

Experimental Properties:

Weak, monoacidic base; aq soln do not absorb CO2 from air|REACTS WITH PROTON DONORS|Hydroxyl radical reaction rate constant = 3.4X10-11 cu cm/molecule-sec at 25 °C (est)

See More Tris(hydroxymethyl)aminomethane Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Tris(hydroxymethyl)aminomethane Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Tris (hydroxymethyl) aminomethane	1 KG	Nov 1, 2024
Mexico	Tromethamine	4.00 TON	Nov 7, 2023
France	tris-buffer	200 G	Oct 11, 2023

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Trometamol77-86-1

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