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Synephrine 94-07-5

Name: Synephrine 94-07-5
Brand: Orient
SKU: pr2512121409
Price: 4 USD
Availability: InStock

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CAS No.:

94-07-5

Grade:

Industrial Grade

Content:

98%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 25KG, 200KG, 1000KG, customized

Price valid (until):

2026-01-12

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

Synephrine Basic information

Plant Extract Introduction Applications Mode of action Risks and Warning References

Product Name:	Synephrine
Synonyms:	oxedrine;SYNEPHERINE;(+/-)-SYNEPHRINE;SYNEPHRINE;4-hydroxy-alpha-(methylaminomethyl)benzyl alcohol;AKOS NCG1-0008;1-[4-HYDROXYPHENYL]-2-METHYLAMINOETHANOL;Synephrine, 98%, from Citrus aurantium L.
CAS:	94-07-5
MF:	C9H13NO2
MW:	167.21
EINECS:	202-300-9
Product Categories:	Herb extract;Plant extracts;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;All Inhibitors;Reduce Weight;Herbs & Natural Remedies;Natural Plant Extract;Inhibitors;Nutritional Ingredients;standardized herbal extract;CITRIMORE;Intermediates & Fine Chemicals;Pharmaceuticals;94-07-5
Mol File:	94-07-5.mol

Synephrine Chemical Properties

Melting point	187 °C (dec.)(lit.)
Boiling point	295.79°C (rough estimate)
density	1.1222 (rough estimate)
refractive index	1.4680 (estimate)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	pKa 9.60±0.02(H2O t = 25.0±0.5 I = 0.01)(Approximate)
form	Solid
color	White to Off-White
Merck	14,9012
Stability:	Hygroscopic
InChI	InChI=1/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3/t9-/s3
InChIKey	YRCWQPVGYLYSOX-DJEYLCQNNA-N
SMILES	C1(=CC=C(O)C=C1)[C@@H](O)CNC \|&1:7,r\|
LogP	-0.450
CAS DataBase Reference	94-07-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	DO7350000
HS Code	29225090

MSDS Information

Provider	Language
1-(4-Hydroxyphenyl)-2-(methylamino)ethanol	English
SigmaAldrich	English

Synephrine Usage And Synthesis

Plant Extract	Synephrine is a kind of biological active substance, mainly extracted from the orange, tangerine peel, green husk and rutaceae plants, is a traditional Chinese medicine and plays an important role of frutus aurantii immaturus effective component, has a strong heart, increase blood volume contraction, blood vessels, high total peripheral vascular resistance and make the left ventricular pressure and the effect of arterial blood pressure, shock resistance, and the effect that reduce weight, but because the Synephrine has the similar structure to that of jute alkali has excited central nervous, the potential side effects of cardiovascular disease, in recent years it is limited to use in the United States, Canada and other countries. Figure 1 the extract of frutus aurantii immaturus Synephrine
Introduction	Synephrine[meaning p-synephrine in most cases], is an alkaloid, occurring naturally in some plants and animals, and has been also supplemented in approved drugs products as its m-substituted analog known as neo-synephrine^[1]. Figure 1 Chemical structure of the synephrine. ; Synephrine[Figure 1] is a key proto-alkaloid found in Citrus aurantium[bitter orange] and other Citrus species[C. reticulata, C. sinensis, C. deliciosa, C. limon, C.limonia, and C. unshiu] as well as in Evodia rutaecarpa[2-5]. It is widely used in weight management and sports performance products. Moreover, it is usually consumed in various foods and juices derived from Citrus species as Seville oranges, mandarin oranges and many other orange-related species containing p-synephrine[7,8]. However, p-synephrine may cause potential cardiovascular hazards as found in many previous studies^[9-11]. P-synephrine[P-s], often referred to as simply synephrine^[12], is an alpha-adrenergic agonist^[13] that also has some beta-adrenergic properties^[14]. P-s occurs naturally in the human body in small quantities and may act as a neurotransmitter^[15]. Since 1927, usually under the name oxedrine, it has been used as a pharmaceutical^[16], commonly in the form of eye drops. Oxedrine is thought to be the primary ingredient in C. aurantium that produces weight loss, but neither this nor whether C. aurantium produces weight loss in humans is firmly established. M-synephrine, often referred to as phenylephrine, is an isomer of p-s. It is also an alpha -adrenergic agonist that also has some beta-adrenergic agonist properties. It has been studied far more extensively than p-s and is one of the two most widely used OTC decongestants today^[12]. In Asian traditional medicine, synephrine was used in the treatment of digestive problems, to stimulate appetite and gastric secretion, in clear contrast with the aim of promoting weight-loss^[17]. In the Mediterranean region, it was used as a cardiac and vascular stimulant, with stomachic, sedative, and general tonic properties^[18]. Its most important and famous application is used for weight management, for the treatment of obesity.
Applications	The most famous application of synephrine is used for the treatment of obesity. Obesity is considered a growing public health issue: more than 1 billion adults are overweight and at least 300 million people are obese[BMIP30 kg/m2]^[19]. These situations lead to increased morbidity and mortality due to diseases such as diabetes mellitus, cardiovascular diseases, hypertension, and cancer^{[19, 20]}. Due to its affinity to a-adrenergic receptors, p-synephrine is marketed as an intravenous drug to treat hypotension^{[17, 21]}. m-Synephrine has been widely employed in parenteral formulations as an intranasal decongestant^{[22, 23]}, a vasopressor agent used in surgical procedures, in priapism treatment, and as a mydriatic agent^[21].
Mode of action	Both m- and p-synephrine activate several types of adrenergic receptors^{[21, 24]}. Synephrine’s mechanism of action as a weight-loss stimulant is attributed to the lipolytic effects that occur with the activation of beta3-adrenergic receptors and consequent thermogenesis[Brunton et al., 2005; Moro and Basile, 2000]. Noteworthy, the occurrence of adverse effects associated with the consumption of synephrine is related to the nonspecific adrenergic stimulation^[17]. The antidepressant effect of synephrine has already been described in rats through the tail suspension test and reserpine-induced hypothermia, two in vivo tests commonly used to screen for antidepressant activity^[27]. Moreover, p-synephrine also demonstrated antidepressant effects through behavioral assays[tail suspension test and forced swimming test] in mice. The antidepressant-like activity in those assays was more pronounced at doses of 3 and 10 mg/kg^[28]. A recent study demonstrated that synephrine acts on serotonergic receptors since its constrictive effects on rat aorta were concentration-dependently antagonized by pre-treatment with 5-HT1D and 5-HT2A antagonists^[29].
Risks and Warning	Since synephrine has structural and pharmacological similarities with other sympathomimetic amines and, therefore, it can cause similar side effects. Unfortunately, studies in the fields are still limited. Animal studies have shown that it can reduce the locomotor activity of mice^[30,31]; reduce the relative mass of the adrenal glands in rats^[2]. In human beings, there are reports that synephrine can cause ischemic colitis and seizure^[21,31]. However, the biggest safety concern associated with synephrine is still related to its potential cardiovascular toxicity. In Canada, between January 1998 and February of 2004, 16 cases of severe cardiovascular symptoms associated with weight-loss products containing synephrine were reported. These incidents determined synephrine’s interdiction in dietary supplements by Health Canada^[32]. In 2010, Health Canada published new guidelines for the use of synephrine in natural products, which establish a daily limit of 30 mg as the maximum allowable dose for synephrine in these products^[33]. The ergogenic mechanisms of sympathomimetic agents such as synephrine include increased heart rate and energy expenditure through central stimulation^[34]. The users can undergo severe functional cardiac effects because of the increases in the after-load and heart rate, which can result in a higher myocardial oxygen demand, decreased diastolic filling, and failure to supply oxygen to the cardiomyocytes^[36]. It has been also found that synephrine may cause a significant increase in systolic pressure^[37] as well as promote an increase in total peripheral resistance during 30–60 min in healthy volunteers^[35]. In vivo studies demonstrated an increase in mortality rate and electrocardiogram abnormalities in rats treated with synephrine for 15 days. The cardiac effects persisted for 15 subsequent days after the end of treatment^[38]. These studies suggest a possible association between synephrine consumption and the occurrence of ventricular arrhythmias and increased cardiac output.

First aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx)

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Synephrine

Other Name:

Benzenemethanol,4-hydroxy-α-[(methylamino)methyl]-;Benzyl alcohol,p-hydroxy-α-[(methylamino)methyl]-;4-Hydroxy-α-[(methylamino)methyl]benzenemethanol;Analeptin;p-Hydroxy-α-[(methylamino)methyl]benzyl alcohol;1-(4-Hydroxyphenyl)-N-methylethanolamine;β-Methylamino-α-(4-hydroxyphenyl)ethyl alcohol;Oxedrine;Parasympatol;Simpalon;Sympathol;Synephrin;Synephrine;Synthenate;Simpatol;S 38537-9;Sympaethamine;Sympaethamin;1-(4-Hydroxyphenyl)-2-(methylamino)ethanol;dl-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol;(±)-Synephrine;(±)-N-Methyloctopamine;(±)-S38537-9;DL-Synephrine;1-Hydroxy-4-[(1-hydroxy-2-methylamino)ethyl]benzene;Ethaphene;NSC 166285;NSC 170956;N-[2-Hydroxy-2-(4-hydroxyphenyl)ethyl]-N-methylamine;Advantra Z;582-84-3;860222-98-6

CAS No.:

94-07-5

Molecular Formula:

C9H13NO2

InChIKeys:

InChIKey=YRCWQPVGYLYSOX-UHFFFAOYSA-N

Molecular Weight:

167.205

Exact Mass:

167.21

EC Number:

202-300-9

NSC Number:

759316|170956|166285

DSSTox ID:

DTXSID0030588

ATC Code:

C - Cardiovascular system|S - Sensory organs

HScode:

2922509090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

52.49000

XLogP3:

-0.03

Appearance:

Solid

Density:

1.2±0.1 g/cm3

Melting Point:

184.5 °C

Boiling Point:

341.1±27.0 °C at 760 mmHg

Flash Point:

163.4±14.3 °C

Refractive Index:

1.572

Water Solubility:

0.0004265 mg/L @ 25 °C (est)

Storage Conditions:

2-8ºC

Collision Cross Section:

134.4 Å² [M+H-H2O]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|132 Å² [M+H-H2O]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More Synephrine Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Synephrine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Greece	synephrine hcl	100 G	May 25, 2026

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