Pterostilbene 537-42-8

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The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

Pterostilbene Basic information Product Name: Pterostilbene Synonyms: AKOS 236-80;3,5-DIMETHOXY-4'-HYDROXYSTILBENE;3',5'-DIMETHOXY-4-STILBENOL;4-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]PHENOL;PTEROSTILBENE;PTEROCARPUS MARSUPIUM;TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE;(E)-3,5-Dimethoxy-4'-hydroxystilbene CAS: 537-42-8 MF: C16H16O3 MW: 256.3 EINECS: 611-041-4 Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Health supplements;Herb extract;Inhibitors;API;537-42-8 Mol File: 537-42-8.mol Pterostilbene Chemical Properties Melting point  89-92 ºC Boiling point  420.4±35.0 °C(Predicted) density  1.169±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  DMSO: >20mg/mL pka 9.96±0.26(Predicted) form  solid color  White or off-white Odor Characteristic λmax 321nm(MeOH)(lit.) Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. InChI InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+ InChIKey VLEUZFDZJKSGMX-ONEGZZNKSA-N SMILES C1(O)=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1 LogP 4.056 (est) Safety Information Hazard Codes  Xi,N Risk Statements  41-51/53 Safety Statements  26-39-61 RIDADR  3077 WGK Germany  3 HazardClass  IRRITANT PackingGroup  Ⅲ HS Code  29095000 MSDS Information Pterostilbene Usage And Synthesis Description Pterostilbene (PTS) is a fragrant-smelling hydrocarbon called "styrene", which is a derivative of resveratrol. It is found in blueberries and Pterocarpus marsupium (PM) heartwood. Similar to resveratrol, PTS has anti-inflammatory, anti-thrombotic, anti-cancer, anti-cancer, anti-hyperlipidemia and antibacterial effects. Chemical Properties Pterostilbene is a white crystalline powder, sensitive to air, soluble in hot methanol, DMSO, insoluble in water. It is a stilbenoid chemically similar to resveratrol and from the leguminous plant Pterocarpus indicus. Occurrence Pterostilbene is a natural molecule found in fruits, vegetables and nuts. Blueberries are often quoted as one of the richest sources of pterostilbene. It is also found in almonds,various Vaccinium berries (including blueberries), grape leaves and vines,and Pterocarpus marsupium heartwood. Uses Substantial studies demonstrate that pterostilbene has diverse pharmacological activities for the prevention and treatment of diseases including inflammation, cancer, diabetes, and dyslipidemia. Pterostilbene has been used: to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells) Definition ChEBI: Pterostilbene is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'. It has a role as an antioxidant, an antineoplastic agent, a neurotransmitter, a plant metabolite, an apoptosis inducer, a neuroprotective agent, an anti-inflammatory agent, a radical scavenger and a hypoglycemic agent. It is a stilbenol, a member of methoxybenzenes and a diether. It derives from a hydride of a trans-stilbene. Preparation Pterostilbene was synthesized from 3,5-dimethoxybenzyl bromide and p-nitrobenzaldehyde by Witting-Hornor reaction, reduction, diazotization and hydrolysis, with a total yield of 53.9%. benefits Pterostilbene is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Pterostilbene is known to have many pharmacological benefits for the prevention and treatment of a wide variety of diseases, including ( cancer (McCormack and McFadden 2012), dyslipidaemia (Rimando et al. 2005), diabetes (Amarnath Satheesh and Pari 2006), cardiovascular degeneration (Amarnath Satheesh and Pari 2008) and pain (Hougee et al. 2005). Biological Activity A cell-permeable methoxylated analog of Resveratrol that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox. Moderately inhibits COX-1 & COX-2 activities (IC50 = 19.8 μM & 83.9 μM, respectively) and induces apoptosis in HL60 cells (IC50 = 70 μM). Also prevents DMBA-induced pre-neoplastic lesions (ED50 = 4.8 μM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin. Side effects The side effects of pterostilbene are relatively minor, but you still need to pay attention to the dosage. Low-dose pterostilbene supplementation improves cholesterol metabolism and reduces triglyceride levels. Side effects include mild weight loss and muscle pain, but dose adjustment is usually not necessary. References [1] ESTRELAJOSé M. Pterostilbene: Biomedical applications.[J]. Critical reviews in clinical laboratory sciences, 2013. DOI:10.3109/10408363.2013.805182. [2] HYUNSOOK KIM  Wallace Y  Kun Ho Seo. Chemistry of Pterostilbene and Its Metabolic Effects[J]. Journal of Agricultural and Food Chemistry, 2020. DOI:10.1021/acs.jafc.0c00070. [3] MACICKOVATATIANA. In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis.[J]. Neuro endocrinology letters, 2010. [4] WASAMON NUTAKUL. Inhibitory Effects of Resveratrol and Pterostilbene on Human Colon Cancer Cells: A Side-by-Side Comparison[J]. Journal of Agricultural and Food Chemistry, 2011. DOI:10.1021/jf202846b.

First aid measures

General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.



——  Q&A  ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.