4-Aminobutyric acid 56-12-2 C4H9NO2

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Product Name: 4-Aminobutyric acid Synonyms: 4-AMINOBUTANOIC ACID;4-AMINOBUTYRIC ACID;4-AMINO-N-BUTYRIC ACID;ALPHA-AMINOBUTANOIC ACID;AMINOBUTYRIC ACID, 4-;AMINOBUTYRIC-4 ACID;AURORA KA-1053;H-4-AMINOBUTYRIC ACID CAS: 56-12-2 MF: C4H9NO2 MW: 103.12 EINECS: 200-258-6 Product Categories: Pharmaceutical intermediates;Peptide;Amino Acids;Biochemistry;non-Proteinorganic Amino Acids;omega-Aminocarboxylic Acids;Pharmaceutical Raw Materials;Starting Raw Materials & Intermediates;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;Amino Acids;Food Additives;Aliphatics;Amino Acids & Derivatives;API;GABA/Glycine receptor;GABA;56-12-2;001 Mol File: 56-12-2.mol 4-Aminobutyric acid Chemical Properties Melting point  195 °C (dec.) (lit.) Boiling point  248.0±23.0 °C(Predicted) density  1.2300 (estimate) FEMA  4288 | 4-AMINOBUTYRIC ACID refractive index  1.4650 (estimate) storage temp.  2-8°C solubility  H2O: 1 M at 20 °C, clear, colorless pka 4.031(at 25℃) form  Powder color  White to almost white Odor at 1.00 % in propylene glycol. savory meaty Odor Type meaty Water Solubility  SOLUBLE Merck  14,430 JECFA Number 1771 BRN  906818 InChIKey BTCSSZJGUNDROE-UHFFFAOYSA-N LogP -3.17 CAS DataBase Reference 56-12-2(CAS DataBase Reference) NIST Chemistry Reference 4-Aminobutanoic acid(56-12-2) EPA Substance Registry System 4-Aminobutanoic acid (56-12-2) Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-20/21/22 Safety Statements  26-36 WGK Germany  2 RTECS  ES6300000 Hazard Note  Irritant TSCA  Yes HS Code  29224995 MSDS Information 4-Aminobutyric acid Usage And Synthesis Description 4-Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone. Although chemically it is an amino acid, GABA is rarely referred to as such in the scientific or medical communities, because the term "amino acid," used without a qualifier, conventionally refers to the alpha amino acids, which GABA is not, nor is it ever incorporated into a protein. In spastic diplegia in humans, GABA absorption becomes impaired by nerves damaged from the condition's upper motor neuron lesion, which leads to hypertonia of the muscles signaled by those nerves that can no longer absorb GABA. Chemical Properties 4-Aminobutyric acid is a white flake or needle-like crystal; slightly odorous, deliquescence; easily soluble in water, slightly soluble in hot ethanol, insoluble in cold ethanol, ether and benzene; decomposition point is 202°C; LD50 (rat, abdominal cavity) 5400mg/kg. History 4-Aminobutyric acid was first synthesized in 1883, and was first known only as a plant and microbe metabolic product. In 1950, however, GABA was discovered to be an integral part of the mammalian central nervous system. Uses 4-Aminobutyric acid is an important inhibitory neurotransmitter in the central nervous system, which has good water solubility and thermal stability. It has been confirmed that GABA, as a small molecular weight non protein amino acid, has edible safety and can be used in the production of beverages and other foods. Studies have shown that a certain amount of GABA can improve the body's sleep quality and reduce blood pressure.The foods contain γ-aminobutyric acid (GABA) at an amount that shows immediate effect of suppressing autonomic nerve activity related to blood pressure increase. Reacts with isothiocyanates to produce thioureas which have antifungal activity. Preparation The synthesis of 4-aminobutyric acid mainly includes the following: the first is the use of potassium Phthaloyl imine and γ- Chloroprene cyanogen or butyrolactone is used as the raw material of GABA. The final product obtained after violent reaction and hydrolysis is GABA; The second is to use pyrrolidone as the initial raw material, hydrolyze it through calcium hydroxide and ammonium bicarbonate, and finally open its ring to obtain GABA; The third is to use butyric acid and ammonia as raw materials of GABA γ GABA was obtained by light reaction under X-ray conditions; The fourth method is to synthesize GABA with propylamine and formic acid by glow discharge; The fifth is to use methyl bromoacetate and ethylene as raw materials to prepare GABA. Methyl 4-bromobutyrate is obtained through polymerization. Finally, the product after ammonolysis and hydrolysis is GABA. The chemical synthesis methods of GABA have the disadvantages of difficult reaction control and high cost. Definition 4-Aminobutyric acid is a gamma-amino acid that is butanoic acid with the amino substituent located at C-4. It has a role as a signalling molecule, a human metabolite, a Saccharomyces cerevisiae metabolite and a neurotransmitter. It is a gamma-amino acid and a monocarboxylic acid. It derives from a butyric acid. It is a conjugate acid of a gamma-aminobutyrate. It is a tautomer of a gamma-aminobutyric acid zwitterion.

First aid measures

General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.



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