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2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone CAS:32384-65-9

Name: 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone CAS:32384-65-9
Brand: Orient
SKU: pr2512241120
Price: 4 USD
Availability: InStock

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CAS No.:

32384-65-9

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-24

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
Synonyms:	(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one;(3R,4S,5R,6R)-3,4,5-Tris[(trimethylsilyl)oxy]-6-[[(trimethylsilyl)oxy]methyl]tetrahydropyran-2-one;2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;D-2,3,4,6-Tetrakis-O-(trimethylsilyl)-gluconic acid delta-lactone;2,3,4,6-Tetrakis-O-triMethylsilyl-D-gluconolactoe;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, d-lactone;2,3,4,6-tetrakis-O-trimethylsilyl-D-glucono1,5 lactone;(3R,5R,6R)-3,4,5-Tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
CAS:	32384-65-9
MF:	C18H42O6Si4
MW:	466.87
EINECS:	608-732-8
Product Categories:	32384-65-9
Mol File:	32384-65-9.mol

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Chemical Properties

Boiling point	417℃
density	0.97
Fp	171℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Oil
color	Colourless to Pale Yellow
Optical Rotation	46.568°(C=0.01g/ml CHCL3)
Stability:	Moisture Sensitive
InChI	InChI=1/C18H42O6Si4/c1-25(2,3)20-13-14-15(22-26(4,5)6)16(23-27(7,8)9)17(18(19)21-14)24-28(10,11)12/h14-17H,13H2,1-12H3/t14-,15-,16+,17-/s3
InChIKey	VNGTZLYNGGLPIZ-NELUYGJANA-N
SMILES	O([C@@H]1[C@H](C(=O)O[C@H](CO[Si](C)(C)C)[C@H]1O[Si](C)(C)C)O[Si](C)(C)C)[Si](C)(C)C \|&1:1,2,6,13,r\|

Safety Information

HS Code

2931900090

MSDS Information

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Usage And Synthesis

Description

It is usually used as the intermediate and raw material in the chemistry synthesis and pharmaceutical industry. Especially, this chemical has been widely used in the design and synthesis of sodium-glucose transporter inhibitors.¹ For example, this substance can be employed as raw material in the preparation of (1s)-1,5-anhydro-1-c-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol, which is commonly known as Dapagliflozin that act as the sodium dependent glucose transporters for treating type 2 diabetes.² Moreover, it can also function as the intermediate for synthesizing empagliflozin, which is a novel and selective sodium glucose co-transporter-2 inhibitor.³ In addition, canagliflozin, another sodium glucose co-transporter-2 inhibitor, can be obtained by utilizing this substance as the intermediate.⁴

Reference

Guo, C.; Hu, M.; DeOrazio, R. J.; Usyatinsky, A.; Fitzpatrick, K.; Zhang, Z. J.; Maeng, J. H.; Kitchen, D. B.; Tom, S.; Luche, M.; Khmelnitsky, Y.; Mhyre, A. J.; Guzzo, P. R.; Liu, S., The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties. Bioorg. Med. Chem. 2014, 22, 3414-3422.
S Thirumalai Rajan; Eswaraiah, S., Process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol and its solvate thereof. US Patent 2015, WO 2015/132803 A2.
Hrapchak, M.; Latli, B.; Wang, X. J.; Lee, H.; Campbell, S.; Song, J. J.; Senanayake, C. H., Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13. J. Label. Compd. Radiopharm. 2014, 57, 687-694.
Nomura, S.; Sakamaki, S.; Hongu, M.; Kawanishi, E.; Koga, Y.; Sakamoto, T.; Yamamoto, Y.; Ueta, K.; Kimata, H.; Nakayama, K.; Tsuda-Tsukimoto, M., Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. J. Med. Chem. 2010, 53, 6355-6360.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone

Other Name:

D-Gluconic acid,2,3,4,6-tetrakis-O-(trimethylsilyl)-,δ-lactone;Gluconic acid,2,3,4,6-tetrakis-O-(trimethylsilyl)-,δ-lactone,D-;2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;(3R,4S,5R,6R)-3,4,5-Tris[(trimethylsilyl)oxy]-6-[[(trimethylsilyl)oxy]methyl]tetrahydropyran-2-one;(3R,4S,5R,6R)-3,4,5-Tri[(trimethylsilyl)oxy]-6-[[(trimethylsilyl)oxy]methyl]tetrahydro-2H-pyran-2-one;(3R,4S,5R,6R)-3,4,5-Tris(trimethylsilyloxy)-6-[(trimethylsilyloxy)methyl]tetrahydro-2H-pyran-2-one;2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone;55515-29-2

CAS No.:

32384-65-9

Molecular Formula:

C18H42O6Si4

InChIKeys:

InChIKey=VNGTZLYNGGLPIZ-WCXIOVBPSA-N

Molecular Weight:

466.865

Exact Mass:

466.86

EC Number:

608-732-8

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

63.22000

XLogP3:

4.42360

Density:

1.0±0.1 g/cm3

Boiling Point:

417.2±45.0 °C at 760 mmHg

Flash Point:

171.3±24.3 °C

Refractive Index:

1.445

See More 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

8 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone	200 KG	Jun 13, 2024
Romania	(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-o	500 KG	Oct 1, 2025
India	2,3,4,6-tetrakis-O-trimethylsilyl-D-glucono-1,5-lactone	200 KG	Jun 4, 2024
Thailand	2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone	1000 KG	Dec 19, 2025
India	2,3,4,6-tetrakis-O-trimethylsilyl-β-D-glucolactone	1200 KG	Dec 4, 2025
Bangladesh	2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-delta-lactone	100 KG	Oct 21, 2024
India	2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone	200 KG	Jun 13, 2024
India	Dapagliflozin	1 KG	Nov 5, 2024

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