Name | Bimatoprost amide |
CAS number | 155205-89-3 |
Description | Bimatoprost is a synthetic analog of prostaglandin F2α, classified as a prostanoid FP receptor agonist, with the CAS Registry Number 155205-89-3. |
Structural formula |  |
Molecular Formula | C23H33NO4 |
Molecular Weight | 387.51 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Cool dry place( away from the light) |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Bimatoprost is a synthetic analog of prostaglandin F2α, classified as a prostanoid FP receptor agonist, with the CAS Registry Number 155205-89-3. Its molecular structure is modified from the natural prostaglandin to include an ethyl amide group at the carboxylic acid terminus, a change intended to enhance its lipid solubility, corneal penetration, and duration of action. This specific amide derivative is the defining feature of the molecule, differentiating it from other prostaglandin analogs used in ophthalmology. It is formulated as a clear, colorless to slightly yellow ophthalmic solution.
The primary mechanism of action for bimatoprost is the reduction of intraocular pressure, which is achieved through increased aqueous humor outflow. It is believed to work via a dual pathway: by primarily enhancing uveoscleral outflow and also, to a lesser degree, increasing trabecular meshwork outflow. It accomplishes this by binding to and activating prostanoid FP receptors on the ciliary muscle, leading to remodeling of the extracellular matrix and widening of the spaces through which the aqueous humor drains. The result is a significant and sustained decrease in IOP, which is crucial for preventing glaucomatous optic nerve damage.
The clinical application of bimatoprost is primarily in the field of ophthalmology. Its main indication is the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Additionally, it is uniquely approved for the treatment of hypotrichosis of the eyelashes, where it promotes increased eyelash growth in terms of length, thickness, and darkness. This cosmetic effect is a secondary consequence of its action on the hair follicle's growth cycle, likely through prolonging the anagen (growth) phase.
This medication is administered topically as an ophthalmic solution, typically as one drop applied to the affected eye(s) once daily in the evening. For eyelash growth, it is applied along the skin of the upper eyelid margin at the base of the eyelashes using a disposable applicator. Systemic absorption is minimal but can occur. Its therapeutic effect on IOP begins within hours, with maximum effect reached after approximately 8 to 12 hours. The eyelash growth effect becomes noticeable after several weeks to months of consistent application.
The safety profile of bimatoprost is generally favorable, but it is associated with several distinctive local side effects. The most common and well-known is a gradual, potentially permanent increase in brown pigmentation of the iris, which is more pronounced in hazel or mixed-color eyes. Other common ocular side effects include conjunctival hyperemia, eyelash growth (in non-cosmetic use), periocular skin darkening, and dry eye symptoms. Rarely, it can cause intraocular inflammation or cystoid macular edema. Systemic side effects are uncommon due to low absorption but may include headaches. Patients must be informed of the potential for permanent iris color change before initiating therapy.
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