API 99% Gaboxadol (hydrochloride) CAS 85118-33-8 Premium Supply

Gaboxadol Hydrochloride More Info

Gaboxadol Hydrochloride is the hydrochloride salt of gaboxadol, a selective extrasynaptic GABAA receptor agonist, assigned the CAS Registry Number 85118-33-8. Its molecular structure is based on an isoxazole ring fused to an azole, a distinct chemical scaffold from benzodiazepines or non-benzodiazepine hypnotics. Salt formation enhances its stability, solubility, and crystallinity as a pharmaceutical substance. The compound was designed to selectively target specific GABAergic subtypes to produce sleep-promoting effects while aiming to minimize the side effects associated with traditional sedative-hypnotics.

The drug's primary mechanism of action is as a selective agonist for GABAA receptors, specifically those containing the delta subunit located extrasynaptically. These receptors are widely distributed in the central nervous system and are crucial for mediating tonic neuronal inhibition. By activating these delta-subunit-containing GABAA receptors, gaboxadol potentiates the baseline tonic inhibitory current mediated by endogenous GABA, leading to a generalized dampening of neuronal activity. This produces a potent sedative-hypnotic effect through a mechanism considered more physiological than the hypnotic action mediated by the alpha-1 subunit.

The clinical development of gaboxadol was focused on the treatment of insomnia, particularly for sleep initiation and maintenance difficulties. It was developed to provide a novel hypnotic with a mechanism distinct from existing drugs, potentially offering unique benefits for sleep architecture, such as enhancing slow-wave sleep. It advanced to Phase III clinical trials for primary insomnia, where its potential to improve both subjective and objective sleep parameters was evaluated. It was investigated as a potential alternative to traditional benzodiazepine receptor agonists.

In clinical trials, the medication was administered orally in tablet form. Its pharmacokinetic profile showed rapid absorption, with peak plasma concentrations reached approximately one hour after dosing. It had a relatively short elimination half-life of about 1.5 hours, making it suitable for sleep induction while aiming to minimize next-day residual sedation. However, its rapid clearance also potentially limited its efficacy for sleep maintenance.

The development of gaboxadol encountered significant safety and efficacy challenges. Clinical trial data indicated its efficacy was not consistently superior to placebo. More critically, adverse event reports emerged concerning perceptual disturbances, including hallucinations and confusional states, particularly at higher doses. These neuropsychiatric side effects, coupled with its limited efficacy, ultimately led to the termination of its global clinical development program, and it failed to gain regulatory approval for the treatment of insomnia. Consequently, it now exists primarily as a historical reference compound in pharmacological research.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.