Product Detail  

CAS Number: 2097002-61-2 Chemical Name: (S)-3-(Hydroxymethyl)-N-(5-((3,5-difluorophenyl)amino)-1H-pyrazol-3-yl)-1-methylpiperidine-4-carboxamide Molecular Formula: C₁₉H₂₂F₂N₆O₂ Molecular Weight: 404.42 g/mol Synonyms: LOXO-195 Related Categories: Next-Generation Pan-NTRK/ROS1 Inhibitor, Oral Selective Tyrosine Kinase Inhibitor (TKI), TRK/ROS1 Fusion Inhibitor, NTRK/ROS1-Positive Solid Tumor & NSCLC Therapeutic Key Highlight: A potent next-generation oral TKI with high selectivity for NTRK1/2/3 and ROS1 fusion mutations, including a broad range of acquired resistance mutations to first-generation TRK/ROS1 inhibitors; exhibits excellent central nervous system (CNS) penetration, effective for brain metastases; indicated for patients with NTRK fusion-positive solid tumors and ROS1-positive non-small cell lung cancer (NSCLC) who have progressed on prior TRK/ROS1 inhibitor therapy, by blocking aberrant kinase signaling to inhibit tumor cell proliferation and survival.