GMP Compliant CAS 40077-57-4 VIP High-Purity Neuropeptide for Biomedical Research

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CAS Number: 40077-57-4
Synonyms: Aviptadil, VIP (human, porcine, rat), Vasoactive Intestinal Polypeptide
Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
Molecular Formula: C₁₄₇H₂₃₈N₄₄O₄₂S
Molecular Weight: 3325.7 - 3325.8
Purity: ≥99% by HPLC (refer to specific Certificate of Analysis)
Form: White to off-white lyophilized powder
Storage: -20°C

🧬 Product Overview & Key Features

Strong Body VIP Peptide is a synthetic form of the 28-amino acid Vasoactive Intestinal Peptide (VIP), a key signaling molecule in the body. It is meticulously produced and characterized to ensure high purity (≥95%) and biological reliability for research applications.

Our VIP peptide is supplied as a lyophilized trifluoroacetate salt, offering excellent solubility in water (1 mg/ml) . This versatility facilitates ease of handling and preparation for various experimental protocols.

Core Research Functions of VIP:

• Immune Modulation & Anti-inflammatory Action: VIP plays a crucial role in downregulating pro-inflammatory cytokines (e.g., TNF-α, IFN-γ) and promoting anti-inflammatory responses, which helps restore immune system balance.

• Neuroprotective & Cognitive Support: As a neuropeptide, VIP supports neuronal health, synaptic transmission, and may aid in cognitive function, including memory.

• Vascular & Respiratory Function: VIP is a potent vasodilator that helps relax vascular smooth muscle and improve circulation. Research has investigated its role in supporting lung function and managing conditions like acute respiratory distress.

• Gut Health Regulation: In the digestive system, VIP helps regulate the secretion of digestive fluids and supports the integrity of the gut lining.

🔬 Key Specifications & Data

• Appearance: White to off-white lyophilized solid

• Solubility: Soluble to 1 mg/ml in water; soluble at 1 mg/ml 

• Physical Form: Powder

• Storage Condition: Store at -20°C. After reconstitution, aliquot and freeze. Stock solutions are stable for up to 3 months at -20°C.

• Handling: Hygroscopic. For laboratory research use only.

💡 Application Areas in Research

VIP is a versatile tool in biomedical research due to its wide range of biological activities. It has been used in studies related to:

• Immunology & Inflammation Research: Investigating pathways of immune regulation and chronic inflammatory response syndromes.

• Neuroscience: Studying neuroprotection, circadian rhythms, synaptic function, and memory.

• Pulmonary & Cardiovascular Research: Exploring mechanisms of vasodilation, pulmonary arterial function, and potential therapeutic avenues for related conditions.

• Gastrointestinal Studies: Researching gut motility, secretion, and barrier function.

• Cancer Research: Some studies investigate its role in inhibiting the growth of certain cancer cell types, such as small-cell lung carcinoma.

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❓ Frequently Asked Questions (FAQ)

Q1: What is the typical starting concentration for in vitro studies with this VIP peptide?
A: Optimal concentration varies by cell type and assay. Literature suggests effective doses can range from low nanomolar (nM) to micromolar (µM) concentrations. We recommend consulting relevant literature for your specific research model and conducting a dose-response experiment to determine the optimal concentration.

Q2: How should I reconstitute and store this peptide to ensure maximum stability?
A: Reconstitute the lyophilized peptide in sterile water  to your desired stock concentration. Vortex gently if needed. Aliquot the stock solution into working volumes to avoid repeated freeze-thaw cycles. Store aliquots at -20°C or below, where they are typically stable for up to 3 months. Keep the main lyophilized vial sealed and stored at -20°C.

Q3: Is this VIP peptide suitable for in vivo animal studies?
A: Our VIP peptide is a high-purity research-grade product. It has been used in published animal studies. However, researchers are responsible for designing their own animal study protocols in compliance with all local ethical and regulatory guidelines.

Q4: Are there any safety data sheets (SDS/MSDS) available for this product?
A: Yes. A material safety data sheet (MSDS/SDS) is available for this product. Please handle all laboratory chemicals with appropriate personal protective equipment (PPE) and refer to the SDS for detailed safety information.

Q5: What is the difference between Aviptadil and VIP?
A: Aviptadil is the International Nonproprietary Name (INN) for the synthetic version of Vasoactive Intestinal Peptide (VIP). In the context of this research product, the terms refer to the same molecular entity.