Exceptionally high-purity NAD. Very fast shipping. Direct from the manufacturer.

Nicotinamide adenine dinucleotide, commonly known as NAD+, is a vital coenzyme found in all living cells that plays a central role in metabolism and cellular physiology. It is a dinucleotide composed of two nucleotides joined through their phosphate groups: one containing an adenine base and the other nicotinamide.

Mechanism of Action

NAD+ primarily functions as an essential coenzyme in redox reactions, acting as an electron carrier. It cycles between an oxidized form (NAD+) and a reduced form (NADH):
Redox Reactions: NAD+ accepts electrons (in the form of a hydride ion) from metabolic substrates during processes like glycolysis, the tricarboxylic acid (TCA) cycle, fatty acid oxidation, and oxidative phosphorylation. This electron transfer is crucial for ATP production and energy metabolism.
Enzymatic Cofactor: NAD+ serves as a cofactor for various dehydrogenase enzymes, facilitating oxidation-reduction reactions essential for cellular respiration and biosynthesis.
Substrate for NAD+-Dependent Enzymes: Beyond redox roles, NAD+ is a substrate for enzymes involved in post-translational modifications, including sirtuins (protein deacetylases), poly(ADP-ribose) polymerases (PARPs), and ADP-ribosyl cyclases, which regulate DNA repair, gene expression, and calcium signaling.
RNA Capping: NAD+ can be incorporated as a non-canonical cap at the 5′ end of RNA transcripts, influencing RNA stability and gene expression regulation.

Biosynthesis and Metabolism

NAD+ levels in cells are maintained through multiple pathways:
De Novo Synthesis: NAD+ can be synthesized from dietary amino acids like tryptophan via the kynurenine pathway.
Preiss-Handler Pathway: Converts dietary nicotinic acid (NA) into NAD+ through intermediate steps.
Salvage Pathway: The predominant pathway in most cells, recycling nicotinamide (NAM), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) back into NAD+ to maintain cellular levels. The rate-limiting enzyme in this pathway is nicotinamide phosphoribosyltransferase (NAMPT).
Methylation and Excretion: Excess NAM is methylated by nicotinamide N-methyltransferase (NNMT) and ultimately excreted, regulating NAD+ homeostasis.

Physiological Roles

Energy Metabolism: NAD+ is indispensable for glycolysis, TCA cycle, and oxidative phosphorylation, enabling efficient ATP production.
Redox Homeostasis: Maintains cellular redox balance by cycling between NAD+ and NADH.
DNA Repair and Genomic Stability: Serves as a substrate for PARPs involved in DNA repair mechanisms.
Regulation of Gene Expression: Through sirtuins, NAD+ influences chromatin remodeling and transcriptional regulation.
Immune Response and Inflammation: Modulates immune cell function and inflammatory processes.
Circadian Rhythm: NAD+ levels influence circadian clock regulation via sirtuin activity.
Aging and Disease: Dysregulation or depletion of NAD+ is linked to aging, metabolic disorders, neurodegeneration, cancer, and cardiovascular diseases.

1. Ultra-High Purity
Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.

2.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.

3.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.