Product Detail  

Retatrutide (LY3437943) – Detailed English Product Description

Basic Specifications

• Chemical Name: Retatrutide
• CAS Number: 2381089‑83‑2
• Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
• Molecular Weight: ~4,731.34 Da
• Purity: ≥99% (HPLC & Mass Spec verified)
• Appearance: White to off‑white sterile lyophilized powder
• Solubility: Freely soluble in bacteriostatic water, distilled water, and aqueous buffers; solubility ~30 mg/mL at pH 7
• Package: Sterile vial (5 mg / 10 mg / 20 mg / 30 mg options)
• Quality Documents: COA, HPLC chromatogram, MS report provided per batch
• Half‑Life: ~6–7 days (prolonged by fatty acid modification)
• Storage: Long‑term at ‑20°C, sealed, dry, light‑protected; avoid freeze‑thaw cycles
• Shelf Life: 24 months (proper storage)

Mechanism of Action

1. GLP‑1 Receptor Activation
   • Boosts glucose‑dependent insulin secretion; suppresses glucagon.
   • Delays gastric emptying; triggers strong satiety signals to reduce appetite.
2. GIP Receptor Activation
   • Enhances insulin sensitivity; amplifies GLP‑1’s weight‑loss effects synergistically.
3. Glucagon Receptor Activation
   • Increases energy expenditure; promotes fat breakdown and reduces liver fat accumulation.
4. Long‑Acting Design
   • C20 fatty diacid moiety binds albumin, extending half‑life for once‑weekly administration.

Core Research Benefits

• Superior Weight Loss: Clinical data shows 11.5%–15.3% body weight reduction in 40 weeks (greater than dual agonists).
• Powerful Glycemic Control: Reduces HbA1c by 1.7%–1.9% in type 2 diabetes research.
• Liver Health Support: Significantly lowers hepatic fat (up to 82.4% reduction in 24 weeks).
• Metabolic Syndrome Research: Ideal for obesity, T2DM, MASLD, and cardiovascular risk studiesEli Lilly and Company.
• Low Hypoglycemia Risk: Glucose‑dependent insulin action ensures safety in glycemic research.

Product Advantages

1. Highest Purity & Stability: ≥99% purity with strict QC; minimal batch‑to‑batch variation.
2. Optimized Solubility: Lyophilized powder dissolves rapidly and completely; reconstituted solution remains stable.
3. Sterile & Endotoxin‑Controlled: Manufactured under cGMP sterile conditions for laboratory injection studies.
4. Complete Technical Support: Full QC documentation provided for compliance and filing.

Important Notice

Bullet Points (for Listings)

• Triple‑Receptor Agonist: GLP‑1 + GIP + Glucagon receptors; superior synergistic metabolic effects
• ≥99% Purity: HPLC & MS verified; full COA, HPLC, MS reports included
• White Lyophilized Powder: Excellent solubility in bacteriostatic water; ready for reconstitution
• Long Half‑Life (~6–7 days): Once‑weekly dosing convenience for research
• Proven Efficacy: 11.5%–15.3% weight loss; 1.7%–1.9% HbA1c reduction in trials
• Liver Fat Reduction: Up to 82.4% decrease in 24 weeks; supports MASLD research
• Strict Quality Control: Sterile production, low endotoxin, consistent batch quality
• Storage: ‑20°C, sealed, dry, light‑protected; 24‑month shelf life

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