Basic Chemical Specifications
- Alias: FTPP, Prohibitin-targeting peptide 1
- Full Sequence: CKGGRAKDC-GG-D(KLAKLAK)₂
- CAS No.: 859216-15-2
- Molecular Formula: C₁₁₁H₂₀₄N₃₆O₂₈S₂
- Molecular Weight: 2412.98 Da
- Appearance: Fine white lyophilized crystalline powder
- Standard Vial Pack: 2mg / 5mg / 10mg per sterile glass vial
- HPLC Purity: ≥99% research grade
Product Introduction & Core Mechanism
Adipotide (FTPP) is a unique synthetic chimeric peptidomimetic with two functional domains connected by a glycine linker, designed for selective white adipose tissue ablation research. Unlike GLP‑1 agonists that suppress appetite, Adipotide acts through vascular targeted apoptosis to cut nutrient supply to fat tissue, representing an entirely distinct obesity research pathway.
Two core functional segments work synergistically:
- Fat vasculature homing domain (CKGGRAKDC)
This cyclic peptide selectively binds prohibitin and annexin A2 receptors, which are highly enriched only on endothelial cells of blood vessels feeding white fat deposits. It achieves precise tissue targeting and avoids binding vessels of muscle, heart or visceral organs. - Pro-apoptotic cytotoxic domain D(KLAKLAK)₂
After cellular internalization, this D-amino acid peptide disrupts mitochondrial membranes and triggers programmed endothelial cell death. Destroyed adipose microvasculature blocks oxygen and nutrition delivery to adipocytes, leading to gradual fat cell atrophy and clearance via natural metabolism.
Key preclinical research outcomes:
- Significant visceral white fat mass reduction (11%–39% body weight drop in obese mouse and primate models)
- Preserves lean muscle mass, no muscle wasting side effects
- Improves insulin sensitivity, serum lipid profiles and alleviates hepatic steatosis
- Widely applied in vascular targeting, fat apoptosis, obesity and metabolic syndrome laboratory trials
Our Adipotide Product Competitive Advantages
- Ultra-high purity ≥99%
Every batch passes HPLC full purity test and LC-MS full-sequence mass spectrum verification. Complete COA, HPLC chromatogram, heavy metal and low-endotoxin test reports (third-party Janoshik testing available) are supplied for all bulk orders; no truncated peptide fragments or oxidation impurities. - Vacuum freeze-drying production
Full moisture removed without preservatives to fully lock complete peptide biological activity. Lyophilized solid powder resists hydrolysis and oxidation during long-distance air & sea cross-border shipping, maintaining stable potency with a 24-month shelf life under cold dark storage. - GMP clean-room sterile manufacturing
Individually sealed single vial packaging to avoid cross-contamination. Custom private labels, bottle sizes and bulk powder split packaging service available for global lab suppliers and metabolic research distributors. - Stable water solubility
Rapidly dissolves in sterile bacteriostatic water to form clear, sediment-free transparent solution, ideal for precise low-dose preparation for in vitro cell culture and in vivo animal trials. - Complete professional technical support
We supply detailed reconstitution guide, temperature storage rules, laboratory dosage reference data and full batch traceability documents for all partners.
Storage & Reconstitution Instructions
- Unopened lyophilized powder: Long-term storage at -20°C away from light and humidity, shelf life up to 24 months; short transit storage at 2–8°C is acceptable.
- Recommended solvent: Sterile bacteriostatic water
- Operation tip: Equilibrate vial to room temperature before opening; slowly solvent along the inner vial wall and swirl gently. Violent shaking triggers peptide aggregation and irreversible activity loss.
- Reconstituted liquid: Seal tightly and refrigerate at 2–8°C, finish all usage within 14 days; avoid repeated freeze-thaw cycles.
Global Wholesale Cooperation Support
- Flexible minimum order quantity & tiered large-volume discount for stable VIP long-term partners
- Low-risk dedicated shipping lines for USA, EU, Brazil, Australia with reduced customs detention probability
- Exclusive one-on-one VIP account manager, fast working-hour response and professional reshipping solutions for logistics issues
Chimeric dual-domain peptide targeting prohibitin receptors on white fat vasculature.
Core research directions: selective visceral fat reduction without appetite suppression, adipose endothelial apoptosis, obesity model study, insulin resistance & fatty liver metabolism research. Unique mechanism different from GLP‑1 weight-loss peptides, protects lean muscle tissue.
✅ Purity ≥99% verified by HPLC & full mass spectrometry sequencing
✅ Available specs: 2mg / 5mg / 10mg per sterile vial
✅ Full set of official COA test documents attached for every batch
✅ Freeze-dried stable powder suitable for worldwide cross-border delivery
✅ Clear transparent solution after reconstitution, simple lab operation
✅ Custom packaging & competitive bulk wholesale pricing
| Items | Specifications |
| Purity | ≥99% verified by HPLC & full mass spectrometry sequencing
|
| CAS No | 859216-15-2 |
| storage | at -20°C away from light and humidity, shelf life up to 24 months |
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We have been deeply engaged in the peptide industry for many years, serving as a source biotechnology factory integrating R&D, synthesis, production and sales.
We strictly follow production and quality control standards, with the whole process adopting aseptic production and independent lyophilization and packaging. Our products feature stable appearance, good solubility and high activity retention.
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