KissPeptin-10 Good price

Key Information on KissPeptin-10

Core physiological functions

Regulation of the hypothalamic-pituitary-gonadal axis (HPG axis): Kisspeptin-10 serves as a key stimulatory factor for GnRH (gonadotropin-releasing hormone) secretion and is crucial for initiating puberty, gonadal development, and maintaining reproductive function.

Inhibition of tumor metastasis: As a product of the KISS1 gene, Kisspeptin-10 is referred to as a "metastasis inhibitor" and can suppress the invasion and metastasis of various cancer cells (such as melanoma and breast cancer) through GPR54.

Recent studies have revealed other critical roles in ameliorating metabolic disorders during pregnancy: In a gestational diabetes mellitus (GDM) model, Kisspeptin-10 upregulates the expression of Glut-4, Insr, and Irs1 by activating the cAMP/PKA pathway, thereby improving placental insulin resistance and optimizing fetal outcomes. In a maternal hypothyroidism model, it partially restores the placental mTOR signaling pathway and glucose metabolism regulators (such as GLUT1 and IGF1/IGF1R).

Protecting the integrity of the blood-brain barrier (BBB): In stroke models, Kisspeptin-10 mitigates ischemia-reperfusion injury via the Nrf2/Claudin-10 pathway, reduces BBB permeability, and decreases neuroinflammation.

In the HIV-1 Tat-induced neuroinflammatory model, inhibition of the RhoA/ROCK pathway upregulated Claudin-5 and alleviated blood-brain barrier (BBB) disruption.

Anti-inflammatory effects: In microglia, Kisspeptin-10 exerts dual inhibition on NLRP3 inflammasomes. On one hand, it suppresses the NF- κ B pathway to reduce the transcription of pro-inflammatory factors; on the other hand, it activates BAG3-dependent autophagy, eliminating damaged mitochondria and activated caspase-1, thereby inhibiting IL-1 β /IL-18 secretion and pyroptosis.

Regulation of bone metabolism: In osteoclasts, Kisspeptin-10 inhibits bone resorption through the GPR54/Dusp18/Src dephosphorylation pathway, thereby preventing bone loss. Vascular regulatory effects: It exhibits vasoconstrictive and angiogenesis-inhibitory activities.

sum up

Kisspeptin-10 is not only a core regulatory peptide in reproductive endocrinology but also demonstrates extensive therapeutic potential in various fields, including metabolism, neuroprotection, anti-inflammatory effects, antitumor activity, vascular homeostasis, and bone health. Currently, most related studies remain at the preclinical stage; however, it has identified novel intervention targets for multiple diseases such as gestational diabetes mellitus (GDM), stroke, neurodegenerative disorders, osteoporosis, and cancer metastasis.