Semax Good price

Semax Main Information

Core Pharmacological Effects

Neuroprotective effects inhibit glutamate-mediated excitatory toxicity, reduce calcium overload, and prevent neuronal apoptosis.

Activates the PI3K/Akt and ERK1/2 pro-survival signaling pathways, upregulates the anti-apoptotic protein Bcl-2, and downregulates the pro-apoptotic proteins Bax and Caspase-3.

Stabilizes mitochondrial function, improves energy metabolism, and mitigates damage caused by ischemia, hypoxia, or oxidative stress. The cognitive-enhancing effect significantly increases the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampus and cerebral cortex.

Promotes dendritic spine formation, synaptic formation, and long-term potentiation (LTP), thereby enhancing learning and memory capabilities.

Inducing the differentiation of hippocampal neural stem cells into mature neurons facilitates neural circuit repair. It improves mood and attention regulation by modulating the serotonin, norepinephrine, and dopamine systems, alleviates anxiety and depression-like behaviors, and enhances wakefulness and concentration.

Clinical and anecdotal reports indicate enhanced cognitive clarity, lexical fluency, and decision-making abilities. The anti-inflammatory and immunomodulatory effects suppress microglial polarization toward the pro-inflammatory M1 phenotype, reducing the release of inflammatory factors such as TNF- α and IL-1 β .

Block the NF- κ B pathway to protect the integrity of the blood-brain barrier and reduce central nervous system inflammation. Antioxidant stress upregulates the activity of antioxidant enzymes such as SOD, GPx, and CAT, directly scavenging free radicals and delaying neuronal aging. It improves cerebral circulation and metabolism by dilating cerebral blood vessels, increasing blood flow to ischemic regions, and enhancing ATP synthesis efficiency.

Other Features

Highly efficient penetration of the blood-brain barrier: Effective concentrations can be detected in the cerebrospinal fluid within 5 – 15 minutes after nasal spray administration.

No hormonal side effects: Due to structural modifications at the C-terminal region, it does not activate the HPA axis and does not affect cortisol secretion.

High safety: virtually non-toxic and non-addictive, with research-grade purity ≥ 98%.

Application Background

Semax has been approved in Russia for the treatment of stroke, transient ischemic attack (TIA), memory impairment, optic nerve disorders, and peptic ulcers. Currently, it is restricted to research purposes in most countries and has not been approved for use as a pharmaceutical product or dietary supplement.