LL-37 is a synthetic human cathelicidin antimicrobial peptide composed of 37 amino acid residues, derived from the C-terminal of human hCAP18 protein. This product is a high-purity lyophilized powder manufactured by solid-phase peptide synthesis, featuring stable molecular structure, low batch difference and high experimental repeatability. It is strictly supplied as a laboratory research-grade chemical reagent for in vitro academic study only.
| Items | Specifications |
| CAS No | 154947-66-7 |
| Product Name | LL37 |
| Molecular Weight | 4493.33 Da |
| Appearance | White lyophilized powder |
| Specification | 10 pieces per box |
| Origin | Guangzhou |
| Purity | ≥98% HPLC |
| Solubility | Soluble in water, dilute acid and DMSO; insoluble in high-concentration salt solutions |
| Storage | Sealed and protected from light at -20°C; avoid repeated freeze-thaw cycles. Aqueous solution can be stored long-term at -80°C |
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1. Reconstitution & Dissolution
- Before use, centrifuge the vial briefly to collect all powder at the bottom.
- Add appropriate solvent: ultrapure water, dilute acetic acid or DMSO is recommended.
- Gently swirl or pipette up and down slowly until fully dissolved; do not shake vigorously to avoid peptide denaturation.
- Prepare working solution on demand. Avoid long-term storage of aqueous solution.
2. Recommended Working Concentration
- Antibacterial / Anti-biofilm test: 1 – 10 μM
- Cell experiment (Immunomodulation / Wound healing): 0.5 – 5 μM
- Skin care formulation: 0.1 – 2 μM (formulate per formula requirements)
3. Dilution Steps
Calculate the required solvent volume based on target concentration. Example for reference:
Take 1 mg LL-37 (MW: 4493.33 Da)
- Moles of 1 mg peptide: ≈ 2.2255×10⁻⁷ mol
- To prepare 10 μM stock solution: add 0.022255 L (22.26 mL) solvent
4. Storage After Dissolution
- Stock solution: Aliquot and store at -80°C, valid for 3–6 months.
- Avoid repeated freeze-thaw cycles.
- Working solution: Use immediately after preparation.
5. Operation Notes
- Wear gloves and masks during operation to prevent contamination.
- Do not use high-salt solution for initial dissolution, which may cause precipitation.
- Keep away from proteases to prevent peptide degradation.
- For in vitro research & formula use only. Not for direct human injection or oral administration.
1. Unopened Lyophilized Powder
- Long-term storage: Seal tightly and keep away from light at -20°C. Shelf life: 24 months.
- Temporary storage: Store at 15–25°C for no more than 7 days.
- Environmental requirement: Keep dry, away from heat sources and strong light.
2. Reconstituted Stock Solution
- Aliquot into single-use portions and freeze at -80°C. Valid for 3–6 months.
- Avoid repeated freeze-thaw cycles to prevent activity loss and peptide degradation.
- For short-term use (1–2 weeks): Keep sealed and shaded at 2–8°C.
3. Working Solution
Prepare and use immediately. Do not store for a long time at room temperature or under refrigeration.
4. Additional Notes
- Centrifuge the vial briefly before opening to prevent powder scattering and moisture absorption.
- Keep away from proteases and high-salt solutions to avoid inactivation.
Hong Kong Bosen Peptide R&D Co., Limited
Hong Kong Bosen Peptide R&D Co., Limited is a professional biotechnology company headquartered in Hong Kong, with a focus on peptide research, development, production and global supply. Rooted in the Greater Bay Area’s strong biotech ecosystem, we integrate cutting-edge R&D capabilities, strict quality control systems and efficient global logistics to deliver high-quality peptide products and technical solutions to customers worldwide.
Core Business & Product Portfolio
We specialize in the R&D, customization and commercial production of high-purity peptides, modified peptides and related biotech raw materials. Our product portfolio covers:
- Therapeutic peptides: SS-31 (Elamipretide), Tirzepatide, Semaglutide, Retatrutide (RT20), etc.
- Functional peptides: GHK-Cu, TB500, KPV, NAD, Glutathione, etc.
- Custom peptide services: Custom synthesis of complex sequences, long-chain peptides (up to 200 amino acids) and cyclic peptides, as well as various modification services (N-methylation, unusual amino acid incorporation, etc.).
R&D & Manufacturing Strength
- Technical expertise: Mastery of core technologies including solid-phase peptide synthesis (SPPS), liquid-phase synthesis, advanced purification (HPLC) and strict structural characterization.
- Quality assurance: All products are produced in compliance with cGMP standards, with complete CoA, HPLC and MS reports to ensure batch-to-batch consistency and high purity (≥98%).
- Production capacity: Equipped with professional production bases in Guangzhou, supporting small-batch R&D samples to large-scale commercial production, with stable supply capacity.
Global Market & Service Philosophy
With a customer base spanning the Philippines, the United States, Brazil, Russia, Bangladesh and other regions, we adhere to the service philosophy of "Quality First, Customer Centric". We provide one-stop services including product consultation, customization, technical support and global logistics solutions (door-to-door delivery, customs clearance assistance), committed to becoming a reliable long-term partner for global biotech enterprises, research institutions and health industry clients.
Vision
We are dedicated to advancing peptide technology innovation, expanding the application of peptides in health and medical fields, and contributing to global human health with high-quality products and professional services.
ECHEMI Editorial Reference
LL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.
Research & Reference Note
LL-37, Human Cathelicidin Antimicrobial Peptide is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals
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