PNC-27 is a 32-residue synthetic peptide composed of an HDM-2 binding domain derived from the p53 tumor suppressor protein (residues 12–26) linked to a penetratin cell-penetrating leader sequence . This peptide functions as a research tool for studying protein-protein interactions involving HDM-2 and p53 pathways. It is supplied as a sterile lyophilized powder in sealed vials, ensuring high stability and bioactivity for research purposes only.
For laboratory research purposes only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
PNC-27 contains the p53-derived sequence that binds to the N-terminal p53 binding site of HDM-2 . The penetratin domain facilitates cellular uptake and proper peptide folding. Research studies have investigated its interactions with HDM-2 protein, which is expressed in the membranes of various cancer cell lines .
The lyophilized formulation preserves the peptide's structural integrity and bioactivity, allowing for consistent and reproducible results in controlled laboratory settings. Each vial is hermetically sealed to prevent moisture absorption and contamination. The product is intended for in vitro research applications, including cell culture studies, protein binding assays, and receptor interaction analyses.
Key Research Applications: Protein-protein interaction studies, HDM-2/p53 pathway research, cell membrane protein targeting investigations, receptor binding assays, in vitro cancer cell biology studies.
Packaging Structure (From Outer to Inner)
Level Description
Outer Packaging Standard cardboard box
Middle Packaging Product box (branded/plain) containing a plastic box inside
Inner Packaging Plastic box holding 10 glass vials with foam or partition protection
Vial Clear glass vial, aluminum-plastic flip-off seal, labeled with product name, dosage, and batch number
Each Plastic Box Contains:
10 vials of PNC-27 (5mg or 10mg per vial)
The vial is individually sealed with label
Foam or plastic partition to prevent vials from bumping into each other
Shipping Methods & Delivery Time
Shipping Method Cost Delivery TimeSpecial Line/ Express $40 (under 5kg) ~14 days
UK Special Line Same as above ~25 days (slightly delayed)
UPS / FedEx $70 7-10 daysShipping Policies
Policy Details
Free Shipping On orders over $1000
Remote Area Fee Some remote areas may incur an extra $35 (as determined by FedEx/UPS)
Lead Time 3-5 business days after payment confirmation
Frequently Asked Questions (FAQ)
Q1: Can I get a sample before placing an order?
Yes, samples are available upon request. Samples are not provided for free. You will need to pay for both the sample cost and the shipping fee. The sample fee will be deducted from your bulk order payment once you proceed with a formal order.
Q2: What payment methods do you accept?
We accept wire transfer (T/T), PayPal, and bank transfer. You may choose the most convenient method for you.
Q3: How and when can I receive my order after payment?
Small quantity orders: Shipped via international express (DHL, FedEx, UPS, etc.). Delivery time: 7-10 days after shipment.
Large quantity orders: Shipped by sea. Delivery time: 15-30 days depending on the destination port.
Special line: ~14 days delivery time (under 5kg, $40).
Q4: Can I use my own label or packaging?
Yes, OEM service is available for bulk orders. We can customize labels, vial dosage, vial cap color, and packaging according to your requirements. Please contact us for details.
Q5: What is your MOQ (Minimum Order Quantity)?
Retail MOQ: 1 kit/dosage/item
Customized packaging (e.g., custom vial size, cap color): 20-50 kits/dosage/item
Q6: Do you provide a Certificate of Analysis (COA) with each order?
Yes, each batch comes with a COA (HPLC purity test report). Third-party testing is also available upon request.
Q7: How should I store the peptide?
Store at -20°C, protected from light, and keep sealed. Once reconstituted, refrigerate at 2-8°C and use within the recommended timeframe.
Q8: What documents will be included with my shipment?
Commercial invoice, packing list, COA, and MSDS will be included with each shipment.
United States
