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2'-O-Methylguanosine High-Purity Modified Nucleoside for RNA Interference and Antisense Therapeutics

Name: 2'-O-Methylguanosine High-Purity Modified Nucleoside for RNA Interference and Antisense Therapeutics
Brand: ONERBIO
SKU: pr2606021257
Price: 10.65 USD
Availability: InStock

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Unit Price:

$10.65/KG EXW

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CAS No.:

2140-71-8

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information

Description

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Product Name: 2'-O-Methylguanosine
CAS Number: 2140-71-8
Molecular Formula: C₁₁H₁₅N₅O₅
Molecular Weight: 297.27 g/mol
Appearance: White to off-white crystalline powder.

2'-O-Methylguanosine is a naturally occurring modified ribonucleoside in which the 2'-hydroxyl group of guanosine is methylated, conferring enhanced nuclease resistance and improved duplex stability when incorporated into oligonucleotides. This high-purity crystalline compound serves as a critical building block for the solid-phase synthesis of siRNA, antisense oligos (ASOs), aptamers, and other modified RNA therapeutics. The 2'-O-methyl modification is widely recognized for reducing immune stimulation, increasing target binding affinity, and prolonging in vivo half-life without compromising Watson-Crick base-pairing fidelity. Supplied as a white to off-white crystalline powder with well-defined physicochemical properties, 2'-O-Methylguanosine is manufactured under strict quality control to meet rigorous research and GMP-compliant production standards, ensuring batch-to-batch consistency for both early-stage discovery and late-stage preclinical development programs. Its reliable reactivity in phosphoramidite chemistry makes it an indispensable tool for medicinal chemists and molecular biologists working on next-generation nucleic acid-based drug platforms.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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Certificates

Basic Info

Product Name:

2′-O-Methylguanosine

Other Name:

Guanosine,2′-O-methyl-;2′-O-Methylguanosine;28548-93-8

CAS No.:

2140-71-8

Molecular Formula:

C11H15N5O5

InChIKeys:

InChIKey=OVYNGSFVYRPRCG-KQYNXXCUSA-N

Molecular Weight:

297.27

Exact Mass:

297.27

HScode:

2934999090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

144

XLogP3:

-1.7

Appearance:

White to Off-white Powder

Density:

2.0±0.1 g/cm3

Melting Point:

233-235 °C @ Solvent: Methanol

Boiling Point:

711.7°C at 760 mmHg

Flash Point:

384.2ºC

Refractive Index:

1.829

Storage Conditions:

Refrigerator

Vapor Pressure:

2.93E-21mmHg at 25°C

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Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

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Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
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