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Kobusone

Name: Kobusone
Brand: Cuicheng Bio
SKU: pr2606081146
Price: 170000 USD
Availability: InStock

Unit Price:

$170000-200000/G FOB

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CAS No.:

24173-71-5

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

5mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Kobusone is a naturally occurring sesquiterpenoid compound found in aromatic and medicinal plants, most notably within the heartwood of Aquilaria sinensis (the source of agarwood) and extracts of Cyperus rotundus (nut grass). Its primary biological function is to act as a potent pancreatic islet β-cell replication inducer and anti-diabetic signaling modulator.

1. Core Anti-Diabetic and β-Cell Regenerative Functions

Stimulation of Islet β-Cell Proliferation: Modern endocrinology research identifies kobusone as a rare natural small molecule capable of inducing the replication of primary pancreatic islet β-cells. It preserves and restores functional islet mass in vivo.
Amelioration of Hyperglycemia: In metabolic disease models (such as diabetic db/db mice), systemic administration of kobusone significantly reduces fasting blood glucose levels and reverses insulin deficiency.
Upregulation of Insulin Secretion: It targets intracellular insulin signaling pathways, driving pancreatic β-cells to increase the synthesis and circulatory secretion of active insulin into the bloodstream.

2. General Pharmacological and Tissue-Protective Profile

In traditional herbal medicine screening pipelines, kobusone contributes a broad spectrum of secondary protective attributes to plant extracts: [1]

Anti-Inflammatory and Analgesic Effects: It works at the molecular level to downregulate pro-inflammatory cytokines and signaling molecules, easing localized swelling and pain responses. [1, 2]
Cellular Antioxidant: Kobusone functions as a free radical scavenger, quenching reactive oxygen species (ROS) to prevent downstream oxidative stress and lipid peroxidation in vulnerable organ tissues.
Antimicrobial and Anti-Allergic Efficacy: It displays mild baseline antibacterial properties and acts as an inhibitor against standard mast cell degranulation pathways, showing promise in anti-allergic applications.
3. Laboratory Research and Assay Utility
- Signal Transduction Tool: In biochemical frameworks, kobusone is utilized in vitro as a biochemical probe to map the pathways governing pancreatic cell cycles. Scientists deploy it to study the specific cell-cycle regulators (such as Cyclin D complexes) that control the proliferation thresholds of endocrine cells.
- Phytochemical Reference Standard: High-purity kobusone serves as an analytical reference standard for High-Performance Liquid Chromatography (HPLC) and Gas Chromatography-Mass Spectrometry (GC-MS) to conduct quality control and standardize the complex essential oil fractions of agarwood-producing trees.

Basic Info

Product Name:

(-)-Kobusone

Other Name:

5-Oxatricyclo[8.2.0.04,6]dodecan-9-one,4,12,12-trimethyl-,(1R,4R,6R,10S)-;5-Oxatricyclo[8.2.0.04,6]dodecan-9-one,4,12,12-trimethyl-,(1R,4R,6R,10S)-(-)-;5-Oxatricyclo[8.2.0.04,6]dodecan-9-one,4,12,12-trimethyl-,[1R-(1R*,4R*,6R*,10S*)]-;(1R,4R,6R,10S)-4,12,12-Trimethyl-5-oxatricyclo[8.2.0.04,6]dodecan-9-one;Kobusone,(-)-;6,7-Epoxy-12-norcaryophyllan-3-one;(-)-Kobusone;Kobusone;10306-22-6

CAS No.:

24173-71-5

Molecular Formula:

C14H22O2

InChIKeys:

InChIKey=UETZJEZFLKASPR-UZWIWUQPSA-N

Molecular Weight:

222.32

Exact Mass:

222.32

Categories:

Sesquiterpene

Characteristics

Density:

1.031±0.06 g/cm3(Predicted)

Melting Point:

60-61°C

See More (-)-Kobusone Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More (-)-Kobusone Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Kobusone

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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