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1-Benzyl-1,2,3,4-tetrahydro-isoquinoline

Name: 1-Benzyl-1,2,3,4-tetrahydro-isoquinoline
Brand: Cuicheng Bio
SKU: pr2606081187
Price: 1000 USD
Availability: InStock

Unit Price:

$1000-1200/G FOB

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CAS No.:

19716-56-4

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

1mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
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Description

1-Benzyl-1,2,3,4-tetrahydroisoquinoline (commonly abbreviated as 1BnTIQ; CAS 19716-56-4) functions primarily as an endogenous neurotoxin, a neurological research probe, and a key structural scaffold for alkaloid synthesis.

Unlike many other plant-derived tetrahydroisoquinolines that offer therapeutic benefits, 1BnTIQ is widely recognized in biochemistry as a crucial pathological marker linked to the etiology of Parkinson's disease (PD).

Core Functions and Research Applications

Endogenous Parkinsonism-Inducing Toxin: In neurotoxicology, 1BnTIQ serves as an experimental model compound for idiopathic Parkinson's disease. It is found naturally in human cerebrospinal fluid (CSF), and clinical data shows its concentration spikes three times higher in PD patients than in healthy controls. Chronic administration of 1BnTIQ to animal models successfully replicates parkinsonian-like behavioral deficits and dopaminergic motor symptoms.
Inducer of Dopaminergic Cell Apoptosis: In cellular assays, it functions by entering dopaminergic neurons via the dopamine transporter (DAT). Once inside, it triggers a powerful neurotoxic cascade: it upregulates pro-apoptotic proteins (Bax), suppresses anti-apoptotic defenses (Bcl-xl), and activates cleaved caspase-3 pathways, ultimately forcing progressive cell death. [1]
Disruption of Dopamine Regulation and L-DOPA Therapy: In pharmacodynamics, 1BnTIQ severely disrupts central neurotransmitter pathways. It impairs natural dopamine release, potentiates monoamine oxidase (MAO)-dependent dopamine oxidation, and directly interferes with L-DOPA therapy. It functions as a risk marker because elevated levels block the therapeutic neurochemical responses of standard anti-Parkinson medications.
Biosynthetic Precursor for Plant Alkaloids: In plant biology and biotechnology, it acts as a primary substrate for enzymes like 1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. This reaction is a foundational step in the secondary metabolic pathway that synthesizes complex, biologically active isoquinoline alkaloids within various plant cell cultures.
Chiral Scaffold for Multidrug Resistance (MDR) Modulators: In medicinal chemistry, the core 1-benzyl-tetrahydroisoquinoline skeleton is used as a synthetic starting point to design novel anticancer agents. Certain modified chemical derivatives function as highly effective P-glycoprotein (P-gp) inhibitors, working to reverse chemotherapy resistance in malignant cell lines.

Basic Info

Product Name:

1-Benzyl-1,2,3,4-tetrahydroisoquinoline

Other Name:

Isoquinoline,1,2,3,4-tetrahydro-1-(phenylmethyl)-;Isoquinoline,1-benzyl-1,2,3,4-tetrahydro-;1,2,3,4-Tetrahydro-1-(phenylmethyl)isoquinoline;1-Benzyl-1,2,3,4-tetrahydroisoquinoline;AR-R 15209;NSC 140739;46808-99-5

CAS No.:

19716-56-4

Molecular Formula:

C16H17N

InChIKeys:

InChIKey=YRYCIFUZSUMAAY-UHFFFAOYSA-N

Molecular Weight:

223.3206

Exact Mass:

223.31

NSC Number:

140739

HScode:

2933499090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

3.44490

Appearance:

Solid

Density:

1.06g/cm3

Boiling Point:

120 °C @ Press: 5 x 10^-3 Torr

Flash Point:

180.1ºC

Refractive Index:

1.588

See More 1-Benzyl-1,2,3,4-tetrahydroisoquinoline Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 1-Benzyl-1,2,3,4-tetrahydroisoquinoline Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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1-Benzyl-1,2,3,4-tetrahydro-isoquinoline

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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