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Ac4GalNAlk

Name: Ac4GalNAlk
Brand: Cuicheng Bio
SKU: pr2606093148
Price: 1000 USD
Availability: InStock

Unit Price:

$1000-1200/G FOB

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CAS No.:

1810852-60-8

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

5 mg

Price valid (until):

2026-07-09

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
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Description
Ac4GalNAlk (Tetraacetylated N-(4-pentynoyl)galactosamine) is a synthetic, chemically modified sugar derivative primarily used as a Metabolic Chemical Reporter (MCR). Its fundamental function is to track, visualize, and map protein glycosylation (specifically O-linked glycoproteins) inside living cells and tissues through a technique known as Metabolic Oligosaccharide Engineering (MOE).

How Ac4GalNAlk Functions (Step-by-Step)

Cellular Entry (The Ac4 Advantage): The four acetyl groups (Ac₄) mask the negative charges of the sugar. This makes the molecule highly hydrophobic, allowing it to easily diffuse across the fatty cell membrane.

Intracellular Activation: Once inside the cell, non-specific enzymes called carboxyesterases strip away the acetyl groups, trapping the modified sugar inside the cytoplasm.

Hijacking the Salvage Pathway: The cell mistakes the remaining GalNAlk monomer for natural N-acetylgalactosamine (GalNAc). Cellular enzymes (such as the GALK2 kinase and AGX1/2 pyrophosphorylases) process it into an active nucleotide-sugar (UDP-GalNAlk).

Glycan Incorporation: Glycosyltransferases in the Golgi apparatus pick up this active nucleotide-sugar and append it directly to newly forming cellular proteins. This places an active chemical tag (an alkyne group) directly onto cell surface markers.

Bioorthogonal Click Chemistry: Because cells do not natively possess alkyne tags, researchers can expose the tagged cell to fluorescently labeled or biotinylated azides. Through a highly specific, harmless Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) reaction, the azide clicks onto the alkyne. This illuminates or tags the specific proteins for advanced microscopy or isolation.
Basic Info

Product Name:
Ac4GalNAlk

CAS No.:
1810852-60-8

Categories:
Bulk Drug Intermediates
Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Ac4GalNAlk

Product Description

Seller Information