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2-Amino Pyridine

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$33-34/MT FOB

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CAS No.:

504-29-0

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-16

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

2-Aminopyridine Basic information

Product Name:	2-Aminopyridine
Synonyms:	PYRIDIN-2-YLAMINE;TIMTEC-BB SBB004394;1,2-dihydro-2-iminopyridine;2-aminoazabenzene;2-amino-pyridin;A-PYRIDYLAMINE;AURORA KA-680;2APY
CAS:	504-29-0
MF:	C5H6N2
MW:	94.11
EINECS:	207-988-4
Product Categories:	Amides and Derivatives;Glycan Labeling and Analysis;Lipophilic and Membrane Probes for Chromatography;Matricies for Mass Spectroscopy Analysis of Glycans;Alphabetical;Analytical Reagents;Analytical/Chromatography;Biochemicals and Reagents;Building Blocks;C5;Chemical Synthesis;Derivatization Reagents;Derivatization Reagents HPLC;Fluorescence;FINE Chemical & INTERMEDIATES;pyridine derivative;Organics;Pyridines derivates;Amines;Aromatics;Heterocycles;Miscellaneous Reagents;Fluorescent Indicators and Probes;Fluorescent Probes;Glycobiology;Heterocyclic Building Blocks;Labels;Lipophilic and Membrane Probes;Particles and Stains;Other Non-Polar or Lipophilic Probes;Post-Translational Modification;Proteomics;Pyridines;Heterocycle-Pyridine series;amine
Mol File:	504-29-0.mol

2-Aminopyridine Chemical Properties

Melting point	59 °C
Boiling point	204-210 °C(lit.)
bulk density	600kg/m3
density	1.0308 (estimate)
vapor pressure	5 hPa (125 °C)
refractive index	1.5560 (estimate)
Fp	198 °F
storage temp.	Store below +30°C.
solubility	890g/l
pka	6.82(at 20℃)
form	Crystalline Powder, Crystals or Flakes
color	Cream to light yellow-beige
Odor	Characteristic odour
Water Solubility	Slightly soluble. 1-5 g/100 mL at 19 ºC
Sensitive	Hygroscopic
Merck	14,473
BRN	105785
Henry's Law Constant	3.9×10³ mol/(m³Pa) at 25℃, HSDB (2015)
Exposure limits	ACGIH:TLV-TWA 0.5 ppm (1.9 mg/m3) OSHA:PEL-TWA 0.5 ppm (2 mg/m3) NIOSH:REL-TWA 0.5 ppm
InChI	1S/C5H6N2/c6-5-3-1-2-4-7-5/h1-4H,(H2,6,7)
InChIKey	ICSNLGPSRYBMBD-UHFFFAOYSA-N
SMILES	Nc1ccccn1
LogP	0.53
CAS DataBase Reference	504-29-0(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridinamine(504-29-0)
EPA Substance Registry System	2-Aminopyridine (504-29-0)

Safety Information

Hazard Codes	T,Xi
Risk Statements	21-25-36/37/38-23/24/25
Safety Statements	26-36/37/39-45-38-28B
OEB	B
OEL	TWA: 0.5 ppm (2 mg/m3)
RIDADR	UN 2671 (AMINOPYRIDINES (o-, m-, p,))
WGK Germany	3
RTECS	US1575000
F	8-21
Autoignition Temperature	>630 °C
Hazard Note	Toxic/Irritant
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	II
HS Code	29333999
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Oral Aquatic Chronic 3 Eye Dam. 1 Skin Corr. 1A
Hazardous Substances Data	504-29-0(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 200 mg/kg
IDLH	5 ppm

2-Aminopyridine Usage And Synthesis

Chemical Properties	2-Aminopyridine is a yellow or white crystalline (sand-like) solid with a characteristic odor. It is soluble in water, alcohol, benzene, ether and hot petroleum ether. It tastes bitter and has anesthetic effect. It is a significant synthetic synthon, with unique dual nucleophilic structure. It can react with ketones, aldehydes, acids, multifunctional esters, halogenated aromatics and other compounds to synthesize five- and six-member azaheterocycles. after prolonged storage, may darken in color.
Uses	2-Aminopyridine is used primarily in the pharmaceutical industry as an intermediate in chemical synthesis. It is used to manufacturing analgesic and anti-inflammatory drugs piroxicam and lornoxicam. 2-Aminopyridine is a basic building block of several heterocyclic compounds and Schiff bases. It has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes. It is a derivatizing agent which can be used as a fluorescent label for oligosaccharide detection, chromatographic separation, fluorometric or mass spectrometric analysis. 2AP and its derivatives are good candidates for antimicrobial, anticorrosion and molecular sensing applications.
Preparation	2-Aminopyridine is manufactured using the reaction of pyridine with sodium amide (Chichibabin amination). It is obtained in high yield after the hydrolysis of the intermediate salt (Merck, 2001; Shimizu et al., 1993).
Application	2-Aminopyridine has also been used to derivatize sialyloligosaccharides for detection in FAB-MS. It can also be used: As a reactant in the synthesis of 3-aroylimidazopyridines from chalcones by aerobic oxidative amidation using copper acetate catalyst. In the synthesis of crystalline Cu(II) complex, di-μ-(2-aminopyridine(N,N′))-bis[(2,6 pyridinedicarboxylate)aquacopper(II)] tetrahydrate using 2,6-pyridinedicarboxylic acid and Cu(CH3COO)2.H2O. As an imprinting molecule for the preparation of poly(methacrylic acid–ethylene glycol dimethacrylate) polymer. It is packed in micro-column for selective solid phase extraction of 2-aminopyridine. As a reactant in the synthesis of 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones in the presence of Lewis acid catalysts. As a reactant in the synthesis of 2-(2-aminopyridinium)acetyl starch with antioxidant property.
Synthesis Reference(s)	The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y Tetrahedron Letters, 11, p. 3901, 1970
General Description	2-aminopyridine appears as white powder or crystals or light brown solid. It is soluble in water and alcohol. It is toxic by ingestion and by inhalation of the dust. It is used to make pharmaceuticals and dyes. (NTP, 1992)
Air & Water Reactions	Decomposes in air. Soluble in water.
Reactivity Profile	2-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents .
Hazard	Toxic.
Health Hazard	2-Aminopyridine causes central nervous system effects.
Fire Hazard	2-Aminopyridine is combustible.
Biological Activity	Aminopyridine 2 (1-((6-aminopyridin-3-yl)methyl)-3-(4-bromophenyl)urea) is an orally available, potent and selective irreversible inhibitor of myeloperoxidase (MPO) th at blocks vasomotor dysfunction in r at aortic rings. Aminopyridine 2 inhibits myeloperoxidase in a mouse model of peritonitis.
Safety Profile	Poison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Toxic effects resemble strychnine poisoning. Human systemic effects by inhalation: somnolence, convulsions, and antipsychotic effects. Human central nervous system effects by inhalation. When heated to decomposition it emits highly toxic fumes of NOx,.
Potential Exposure	2-Aminopyridine is used in the manufacture of pharmaceuticals; especially antihistamines.
Carcinogenicity	The LD50 in mice by intraperitoneal injection was 35 mg/kg; lethal doses in animals also produced excitement, tremors, convulsions and tetany.1 Fatal doses were readily absorbed through the skin. A 0.2 M aqueous solution dropped in a rabbit’s eye was only mildly irritating. 2-Aminopyridine was not mutagenic in a variety of Salmonella tester strains with or without metabolic activation.
Environmental fate	Soil. When radio-labeled 4-aminopyridine was incubated in moist soils (50%) under aerobic conditions at 30 °C, the amount of 14CO2 released from an acidic loam (pH 4.1) and an alkaline, loamy sand (pH 7.8) was 0.4 and 50%, respectively (Starr and Cunningham, 1975). Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).
Shipping	UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods	It crystallises from *benzene/pet ether (b 40-60o) or CHCl3 /pet ether. [Beilstein 22/8 V 280.]
Incompatibilities	Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides
Waste Disposal	Incineration with nitrogen oxides removal from effluent gas.
References	[1] RAO R N, CHANDA K. 2-Aminopyridine – an unsung hero in drug discovery[J]. Chemical Communications, 2021, 3: 343-382. DOI:10.1039/D1CC04602K. [2] D. M. BYSTROV L. L F. Reactivity of 2-aminopyridine N-oxides[J]. Russian Chemical Bulletin, 2024, 73 1: 33-52. DOI:10.1007/s11172-024-4120-2. [3] KUMPINA I, BASKEVICS V, WALBY G D, et al. Synthesis of 2-Aminopyridine-Modified Peptide Nucleic Acids[J]. Synlett, 2023, 25 1: 0. DOI:10.1055/a-2191-5774. [4] MEHMET TüMER. Antimicrobial activity studies of the binuclear metal complexes derived from tridentate Schiff base ligands[J]. Transition Metal Chemistry, 1999, 24 4: 414-420. DOI:10.1023/A:1006973823926.

2-Aminopyridine Preparation Products And Raw materials

Raw materials

Toluene-->Sodium carbonate-->Pyridine-->Sodium amide-->2-Bromopyridine-->6-Aminonicotinic acid-->Stainless steel tank

Preparation Products

2-Chloropyridine-->2-CHLORO-5-FLUOROISONICOTINIC ACID-->2-Bromopyridine-->2-Chloro-5-nitropyridine-->N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE-->2-Hydroxy-5-nitropyridine-->2-Fluoropyridine-5-boronic acid-->3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one-->7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE-->2-(5-BROMO-2-PYRIDYLAZO)-5-(DIETHYLAMINO)PHENOL-->5-(AMINOMETHYL)PYRIDIN-2-AMINE-->2-Acetamido-5-fluoropyridine-->1-(2-Pyridylazo)-2-naphthol-->Lornoxicam-->2-Amino-5-nitropyridine-->2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER-->PYRIDINE-2,3,6-TRIAMINE-->2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID-->Imazosulfuron-->2-Fluoro-5-iodopyridine-->2,5-Dibromo-3-nitropyridine-->IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID-->Tenoxicam-->2-ACETAMIDO-5-AMINOPYRIDINE-->2,6-Diaminopyridine-->IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER-->Sulfasalazine-->2-Acetamido-5-nitropyridine-->2-Chloro-5-iodopyridine-->Piroxicam-->2-Benzylaminopyridine-->Sulfapyridine

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Basic Info

Product Name:

2-Aminopyridine

Other Name:

2-Pyridinamine;Pyridine,2-amino-;o-Aminopyridine;α-Aminopyridine;2-Aminopyridine;1,2-Dihydro-2-iminopyridine;2-Pyridylamine;α-Pyridinamine;α-Pyridylamine;2-Pyridinylamine;NSC 431;29212-31-5;45505-67-7;102769-74-4;2222571-76-6

CAS No.:

504-29-0

Molecular Formula:

C5H6N2

InChIKeys:

InChIKey=ICSNLGPSRYBMBD-UHFFFAOYSA-N

Molecular Weight:

94.11

Exact Mass:

94.11

BRN:

105785

EC Number:

207-988-4

UNII:

WSX981HEWU

ICSC Number:

0214

NSC Number:

431

UN Number:

2671

DSSTox ID:

DTXSID0024505

Color/Form:

White leaflets or large colorless crystals|WHITE POWDER OR CRYSTALS|White powder, leaflets, or crystals.|Leaflets, or large crystals

HScode:

29333999

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

38.9

XLogP3:

0.5

Appearance:

Cream to light yellow-beige Crystalline Powder, Crystals or Flakes

Density:

1.065 g/cm³ @ Temp: 20 °C

Melting Point:

58.1 °C

Boiling Point:

210.6 °C

Flash Point:

198 °F

Refractive Index:

1.56552 (65ºC)

Water Solubility:

H2O: Slightly soluble . 1-5 g/100 mL at 19 ºC

Storage Conditions:

Refrigerator, Under Inert Atmosphere

Vapor Pressure:

5 hPa (125 °C)

Vapor Density:

Relative vapour density (air = 1): 3.2

Toxicity:

Oral-rat LD50: 200 mg/kg; Oral-Mouse LD50: 145 mg/kg

Flammability characteristics:

Open flame is flammable; high heat decomposes toxic nitrogen oxide gas

Odor:

Characteristic odor

PH:

BASE

Dissociation Constants:

pKa 6.82 @ 20 °C; Ka 1.51x10-7 @ 20 °C|pKa= 6.86 @ 20 °C|pKa= 6.9 @ 20 °C

Experimental Properties:

Exists as a tautomeric amino and imino forms. Amino form predominates over imino form; ratio 1000:1

Air and Water Reactions:

Decomposes in air. Soluble in water.|Soluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Profile:

2-AMINOPYRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents (NTP, 1992).|AMINOPYRIDINES are amines. Highly toxic, may cause epilepsy-like convulsions, toxic effects resemble strychnine poisoning. When heated to decomposition (over 200° C), it emits highly toxic fumes of oxides of nitrogen [Sax, 9th ed., p. 193].

Ionization Potential:

8.00 eV

Flammable Limits:

Combustible Solid

Physical Dangers:

Dust explosion possible if in powder or granular form, mixed with air.

See More 2-Aminopyridine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Skin corrosion, Category 1

Serious eye damage, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H314 Causes severe skin burns and eye damage H412 Harmful to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs, strong oxidants and strong acids.IN GENERAL MATERIALS ... TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS ... SHOULD BE STORED IN COOL, WELL-VENTILATED PLACE, OUT OF ... SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED & MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED.

See More 2-Aminopyridine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	2-Aminopyridine	100 KG	Sep 10, 2024
India	2-Amino pyridine	1 KG	Sep 26, 2023

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