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2-Nitrochlorobenzene88-73-3C6H4ClNO2

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CAS No.:

88-73-3

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Description

Product Detail

2-Nitrochlorobenzene Basic information

Product Name:	2-Nitrochlorobenzene
Synonyms:	1-CHLORO-2-NITROBENZENE;2-cnb;2-CHLORONITROBENZENE;2-Chloro-1-nitrobenzene;2-NITROCHLOROBENZENE;chloro-1nitro-2benzene;Chloro-o-nitrobenzene;Nitrochlorobenzene, o-
CAS:	88-73-3
MF:	C6H4ClNO2
MW:	157.55
EINECS:	201-854-9
Product Categories:	alkyl chloride\| nitro-compound;Building Blocks;Chemical Synthesis;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Alpha Sort;Analytical Standards;AromaticsVolatiles/ Semivolatiles;C;CAlphabetic;CHChemical Class;Chemical Class;ChloroAnalytical Standards;Intermediates of Dyes and Pigments;Benzene derivatives;Halogenated;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Agrochemical Intermediates
Mol File:	88-73-3.mol

2-Nitrochlorobenzene Chemical Properties

Melting point	31-33 °C (lit.)
Boiling point	246 °C (lit.)
density	1.348 g/mL at 25 °C (lit.)
vapor density	5.4 (vs air)
vapor pressure	0.04 mm Hg ( 25 °C)
refractive index	1.5520 (estimate)
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	alcohol: soluble
form	Fused Crystalline Mass
color	Yellow
PH	6 (0.4g/l, H2O, 20℃)
explosive limit	1.15-13.1%(V)
Water Solubility	0.43 g/L (20 ºC)
Merck	14,2151
BRN	509273
Henry's Law Constant	1.1×10⁰ mol/(m³Pa) at 25℃, Altschuh et al. (1999)
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, strong bases, alkali metals.
InChI	1S/C6H4ClNO2/c7-5-3-1-2-4-6(5)8(9)10/h1-4H
InChIKey	BFCFYVKQTRLZHA-UHFFFAOYSA-N
SMILES	[O-][N+](=O)c1ccccc1Cl
CAS DataBase Reference	88-73-3(CAS DataBase Reference)
IARC	2B (Vol. 65, 123) 2020
NIST Chemistry Reference	Benzene, 1-chloro-2-nitro-(88-73-3)
EPA Substance Registry System	o-Chloronitrobenzene (88-73-3)

Safety Information

Hazard Codes	T
Risk Statements	22-24-52-53-52/53
Safety Statements	36/37/39-45-60-38-28A
RIDADR	UN 1578 6.1/PG 2
WGK Germany	2
RTECS	CZ0875000
Autoignition Temperature	500 °F
Hazard Note	Toxic
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	II
HS Code	29049085
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Oral
Hazardous Substances Data	88-73-3(Hazardous Substances Data)

MSDS Information

Provider	Language
2-Nitrochlorobenzene	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Nitrochlorobenzene Usage And Synthesis

Chemical Properties	yellow solid with a characteristic odour
Uses	Intermediate, especially for dyes.
Uses	Chemical intermediate in manufacture of dyes, picric acid, lumber preservatives, and diaminophenol hydrochloride (a photographic developer)
Uses	1-Chloro-2-nitrobenzene was used in the synthesis of 1-hydroxybenzotriazole derivatives. It is important as a precursor to other compounds due to the two reactive sites present on the molecule.
Definition	ChEBI: 1-chloro-2-nitrobenzene is a C-nitro compound that is nitrobenzene in which one of the ortho- hydrogens has been replaced by chlorine. It is a C-nitro compound and a member of monochlorobenzenes.
Production Methods	Nitration of chlorobenzene with mixed acid (30/56/14) typically gives an isomer mix in 98 % yield consisting of 34 – 36 % 2-Nitrochlorobenzene, 63 – 65 % 4- chloronitrobenzene, and only ca. 1 % 3- chloronitrobenzene. The ortho – para ratio of about 0.55 is in sharp contrast to the 1.6 obtained with nitrotoluene isomers. As with the nitration of toluene, much work has been done on isomer control so that the producer might have some flexibility towards the balance of isomer demand. Although no major change in ratio has been achieved, the situation is better for nitrochlorobenzene than nitrotoluenes, because the favored isomer is in much greater demand. In further contrast to the nitration of toluene, the nitration of chlorobenzene in the presence of phosphoric acid decreases the proportion of 4-Nitrochlorobenzene, and the use of phosphoric acid in the presence of a transition-metal catalyst is said to increase the ortho – para ratio to ca. 0.8.
General Description	Yellow crystals with an aromatic odor. Sinks in water.
Air & Water Reactions	2-Nitrochlorobenzene may be sensitive to prolonged exposure to air and light. Insoluble in water.
Reactivity Profile	O-NITROCHLOROBENZENE is incompatible with strong bases and strong oxidizing agents. 2-Nitrochlorobenzene will react with ammonia.
Hazard	Toxic by inhalation and ingestion. Combustible. Questionable carcinogen.
Health Hazard	INHALATION: Headache, languour, anemia. Irritation of nose and throat, cyanosis, shallow respiration, convulsions, and coma. EYES: Irritation. SKIN: Irritation. INGESTION: Forms methemoglobin giving rise to cyanosis and blood changes.
Flammability and Explosibility	Not classified
Safety Profile	Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Poison by ingestion, skin contact, and probably inhalation. Combustible when exposed to heat or flame. To fight fire, use water, foam. Potentially explosive reaction with ammonia at 160℃/30 bar. When heated to decomposition it emits toxic fumes of Cl-, NOx, and phosgene. See also other chloronitrobenzene entries and NITRO COMPOUNDS of AROMATIC HYDROCARBONS.
Purification Methods	Crystallise it from EtOH, MeOH or pentane (charcoal). [Beilstein 5 IV 721.]
Toxics Screening Level	The Initial Risk Screening Level (IRSL) for 1-chloro-2-nitrobenzene (CAS# 88-73-3) is 0.21 μg/m3 based on an annual averaging time.

2-Nitrochlorobenzene Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Sulfuric acid-->Nitric acid-->Dimethyl sulfoxide-->Copper(I) chloride-->Chlorobenzene-->4-Chloronitrobenzene-->2-Nitroaniline-->1-Chloro-3-nitrobenzene-->POTASSIUM NITRITE

Preparation Products

o-Phenylenediamine-->o-Toluidine-->4-Chloronitrobenzene-->o-Anisidine-->2-Mercaptobenzothiazole-->2-Chloroaniline-->Guaiacol-->2,4-Dinitrochlorobenzene-->2-Aminophenol-->2-Nitroaniline-->2-Nitrophenol-->Pigment Yellow 13-->2-Aminobenzenethiol-->Domperidone-->3-Amino-4-hydroxybenzenesulphonamide-->2-Fluoroaniline-->Aniline-2-sulfonic acid-->N-Methyl-1,2-benzenediamine dihydrochloride-->2-Mercaptobenzimidazole-->o-Phenetidine-->2-Chloro-6-nitrotoluene-->2-(4-METHYLPHENYL)-BENZOTHIAZOLE-->N-METHYL-2-NITROANILINE-->1-Fluoro-2-nitrobenzene-->Disperse Yellow Se-Fl-->Bis(2-nitrophenyl) disulfide-->ANILAZINE-->2-Nitroanisole-->2-Fluorophenol-->4-Chloro-3-nitrobenzenesulfonyl chloride-->2-CHLOROANILINE HYDROCHLORIDE-->2-Nitrodiphenylamine-->2-chlorobenzenediazonium-->FAST ORANGE GR SALT-->o-chlorobenzenediazonium chloride, compound with zinc chloride

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Basic Info

Product Name:

1-Chloro-2-nitrobenzene

Other Name:

Benzene,1-chloro-2-nitro-;1-Chloro-2-nitrobenzene;o-Chloronitrobenzene;2-Chloro-1-nitrobenzene;o-Nitrochlorobenzene;ONCB;2-Nitrochlorobenzene;2-Chloronitrobenzene;1-Nitro-2-chlorobenzene;NSC 36934;2-Nitrophenyl chloride;2-Nitro-1-chlorobenzene;o-Nitrobenzene chloride

CAS No.:

88-73-3

Molecular Formula:

C6H4ClNO2

InChIKeys:

InChIKey=BFCFYVKQTRLZHA-UHFFFAOYSA-N

Molecular Weight:

157.55

Exact Mass:

157.55

BRN:

509273

EC Number:

201-854-9

HScode:

29049085

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

45.8

XLogP3:

2.24

Appearance:

Yellow Fused Crystalline Mass

Density:

1.368 x 10^-3 g/cm³ @ Temp: 242 °C

Melting Point:

32 °C

Boiling Point:

245.5 °C

Flash Point:

>230 °F

Refractive Index:

1.580

Water Solubility:

H2O: 0.43 g/L (20 ºC);alcohol: soluble

Storage Conditions:

Store below +30°C.

Vapor Pressure:

0.04 mm Hg ( 25 °C)

Vapor Density:

5.4 (vs air)

Toxicity:

Oral-Rat LD50: 268 mg/kg; Oral-Mouse LD50: 135 mg/kg

Flammability characteristics:

Open flame is flammable; high heat emits toxic chloride and nitrogen oxide gas

Explosive limit:

1.15-13.1%(V)

See More 1-Chloro-2-nitrobenzene Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Carcinogenicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H331 Toxic if inhaled H350 May cause cancer H372 Causes damage to organs through prolonged or repeated exposure H411 Toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. NO contact with flammables. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from combustible substances, reducing agents and food and feedstuffs.Store in cool, dry, well-ventilated location. Separate from alkalies and oxidizing materials.

See More 1-Chloro-2-nitrobenzene Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	2-Chloronitrobenzene	200 KG	Aug 30, 2023

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