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Dequalinium chloride522-51-0

Name: Dequalinium chloride522-51-0
Brand: OORENT
SKU: pr2606231894
Price: 33 USD
Availability: InStock

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$33-34/MT FOB

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CAS No.:

522-51-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

ShangHai

Brand:

OORENT

Packaging:

vial

Price valid (until):

2026-07-23

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Dequalinium chloride Basic information

Product Name:	Dequalinium chloride
Synonyms:	1,1'-DECAMETHYLENEBIS(4-AMINOQUINALDINIUM CHLORIDE);1,1'-DECAMETHYLENEBIS(4-AMINOQUINALDINIUM) DICHLORIDE;1,1'-(1,10-DECANEDIYL)BIS(4-AMINO-2-METHYLQUINOLINIUM) DICHLORIDE;DEQUALINIUM CHLORIDE;DEQUALINIUM DICHLORIDE;DECA;dequadinchloride;dequafungan
CAS:	522-51-0
MF:	C30H40Cl2N4
MW:	527.57
EINECS:	208-330-9
Product Categories:	FLUOMIZIN;Potassium channel;522-51-0
Mol File:	522-51-0.mol

Dequalinium chloride Chemical Properties

Melting point	≥300 °C(lit.)
storage temp.	2-8°C
solubility	Slightly soluble in water and in ethanol (96 per cent).
form	Solid
color	Beige
Merck	13,2930
Stability:	Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Major Application	pharmaceutical (small molecule)
Cosmetics Ingredients Functions	ANTIMICROBIAL ANTIPLAQUE DEODORANT ORAL CARE
InChIKey	LTNZEXKYNRNOGT-UHFFFAOYSA-N
SMILES	C12C=CC=CC1=C(C=C(C)[N+]=2CCCCCCCCCC[N+]1C(C)=CC(N)=C2C=CC=CC=12)N.[Cl-].[Cl-]
CAS DataBase Reference	522-51-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
RTECS	VA0700000
F	8
Storage Class	11 - Combustible Solids

MSDS Information

Provider	Language
Dequalinium chloride	English
SigmaAldrich	English

Dequalinium chloride Usage And Synthesis

Description	Dequalinium Chloride is a a potent and selective non-peptide blocker of the apamin-sensitive small conductance Ca2+-activated K+ channel (IC50 = 1.1 mM).
Chemical Properties	White or yellowish-white powder, hygroscopic.
Originator	Dequsan,Sante
Uses	Dequalinium Chloride is a quaternary ammonium cation and the active ingredient in various medications including antiseptic and anti-malarial agents.
Definition	ChEBI: Dequalinium chloride is an organic chloride salt that is the dichloride salt of dequalinium. It has a role as an antiseptic drug, a mitochondrial NADH:ubiquinone reductase inhibitor, an antifungal agent and an antineoplastic agent. It contains a dequalinium.
Manufacturing Process	a) 15 g of 4-aminoquinaldine, 15 g of decamethylene diiodide and 200 ml of methyl ethyl ketone were refluxed together for 400 hours. The mixture was allowed to cool, the precipitate filtered off, washed with methyl ethyl ketone, and 1,1'-decamethylenebis(4-aminoquinaldinium chloride) recrystallized from ethyl alcohol containing a little methyl alcohol. b) 160 g of 4-aminoquinaldine, 174 g of decamethylene diiodide and 1,500 ml of methyl isobutyl carbinol were heated together at 120°C for 90 hours. The mixture was allowed to cool, the precipitate filtered off, washed with methyl ethyl ketone and 1,1'-decamethylenebis(4-aminoquinaldinium chloride) recrystallized from ethyl alcohol containing a little methyl alcohol. b) 160 g of 4-aminoquinaldine, 174 g of decamethylene diiodide and 1,500 ml of methyl isobutyl carbinol were heated together at 120°C for 90 hours. The mixture was allowed to cool, the precipitate filtered off, washed with methyl ethyl ketone and 1,1'-decamethylenebis(4-aminoquinaldinium chloride) recrystallized from ethyl alcohol containing a little methyl alcohol.
Brand name	Decabis;Dequacaine;Dequafungan;Dequin;Faringina;Gargilon;Grocreme;Labosept;Maltyl;Phylletten;Soor-gel;Sorot;Tetesept.
Therapeutic Function	Antiseptic, Antifungal
World Health Organization (WHO)	Skin reactions to dequalinium chloride, including necrotic lesions, have been reported. It remains available as a mouth and throat disinfectant in many countries.
General Description	Dequalinium Chloride is a topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration.
Biological Activity	Dequalinium is a quaternary ammonium cation with diverse biological activities. It has antifungal activity against C. albicans, C. glabrata, and C. krusei (MICs = 0.5-2, 64-256, and 128 μg/ml, respectively), antitrichomonal activity against T. vaginalis (MICs = 28.8-230.4 μg/ml), and antibacterial activity against a panel of aerobic and facultative anaerobic bacteria (MICs = 0.25-256 μg/ml). Dequalinium inhibits apamin binding to, and net potassium loss mediated by, SKCa channels in guinea pig hepatocytes stimulated by angiotensin II (Item No. 17150). In vivo, dequalinium (1-10 mg/kg) inhibits primary and recurrent tumor growth in a W163 rat colon carcinoma isograft model.
References	1) Miyataet al.(2014),Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1; Proc. Natl. Acad. Sci. USA11114406 2) Frey Tirriet al.(2011),Antimicrobial topical agents used in the vagina; Curr. Probl. Dermatol.4036 3) Castleet al.(1993),Dequalinium: a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle; Eur. J. Pharmacol.236201 4) Orzaezet al.(2011),Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain; Apoptosis16460

Dequalinium chloride Preparation Products And Raw materials

Raw materials

1,10-DIIODODECANE-->4-AMINO-2-METHYLQUINOLINE

Pls input... Shop TRANS-2-DECEN-1-OL18409-18-2-Detailed Image 2

Basic Info

Product Name:

Dequalinium chloride

Other Name:

Quinolinium,1,1′-(1,10-decanediyl)bis[4-amino-2-methyl-,chloride (1:2);Quinaldinium,1,1′-decamethylenebis[4-amino-,dichloride;Quinolinium,1,1′-(1,10-decanediyl)bis[4-amino-2-methyl-,dichloride;1,1′-Decamethylenebis[4-aminoquinaldinium chloride];BAQD 10;Decamethylenebis[4-aminoquinaldinium chloride];Dequadin chloride;Dequalinium chloride;Sorot;Decamine;Efisol;Dekamin;Evazol;Dekadin;Dequavagyn;Grocreme;Dequavet;Polycidine;Decamine (pharmaceutical);Ivazil;Sanoral;Sentril;Oralgol;Rumilet;Dequadin;Labosept;Dequacets;Fluomycin N;BADQ 10;Dekamiln;Eriosept;Decatylen;Phylletten;Optipect;Dequafungen;LDN 0096422;NSC 166454;Fluomizin;856599-47-8;1257422-27-7

CAS No.:

522-51-0

Molecular Formula:

C30H40N4.2Cl

InChIKeys:

InChIKey=LTNZEXKYNRNOGT-UHFFFAOYSA-N

Molecular Weight:

527.57

Exact Mass:

526.263000

EC Number:

208-330-9

UNII:

XYS8INN1I6

DSSTox ID:

DTXSID3045144

HScode:

2933499090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

59.80000

XLogP3:

1.34060

Melting Point:

326 °C (decomp)

Storage Conditions:

2-8°C

See More Dequalinium chloride Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Dequalinium chloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

6 Inquiries

Country	Product	Purchase Quantity	Date Posted
Thailand	Dequalinium Chloride	1 KG	Jun 18, 2024
Thailand	Dequalinium chloride	1 KG	Jun 14, 2024
Egypt	Dequalinium chloride	500 KG	Sep 23, 2025
Nigeria	Dequlinium chloride	20.00 KG	Jun 23, 2026
Thailand	Dequalinium Chloride	1 KG	Jun 17, 2024
South Korea	Muscle Powder 99% High Purity Raw Steroid Powders Deca 300mg Finished Oil for Muscle Mass	1 MT	Oct 16, 2023

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