LL-37 Cathelicidin Antimicrobial Peptide Human CAS 154947-66-7 Research Grade Powder

1. Product Overview

LL-37 is a human-derived cationic antimicrobial peptide consisting of 37 amino acids, belonging to the cathelicidin family of host defense-related peptides. It is the only known human cathelicidin peptide and is widely studied in the field of innate immunity, cellular signaling, and peptide biology research.

This product is supplied as a synthetic, high-purity lyophilized powder designed strictly for laboratory research use only (RUO). It is manufactured under controlled conditions to ensure batch-to-batch consistency, high sequence fidelity, and stable physicochemical properties suitable for advanced biochemical and molecular biology applications.

LL-37 is frequently used in experimental studies involving peptide-membrane interactions, inflammatory signaling pathways, microbial membrane modeling, and structural biology research.

2. Chemical & Physical Information

• Product Name: LL-37 (Human Cathelicidin Peptide)
• CAS Number: 154947-66-7
• Sequence Length: 37 amino acids
• Molecular Type: Synthetic linear peptide
• Appearance: White to off-white lyophilized powder
• Purity: ≥ 95% / ≥ 98% (depending on specification batch)
• Solubility: Soluble in sterile water or dilute acidic aqueous solutions
• Storage: 2–8°C for short-term; -20°C for long-term stability
• Stability: Stable under lyophilized conditions when protected from moisture and light

3. Structural Characteristics

LL-37 is characterized by its amphipathic and cationic structure, which allows it to interact with lipid bilayers and biological membranes in experimental systems. Its structural flexibility makes it a valuable model peptide in studies involving:

• Peptide–membrane interaction modeling
• Charge-based molecular binding studies
• Structural conformation analysis under different environmental conditions
• Protein folding and aggregation behavior in vitro

Due to its unique sequence and physicochemical profile, LL-37 is widely utilized in comparative peptide research and computational biology simulations.

4. Research Applications (Non-Clinical Use Only)

This product is intended exclusively for scientific research and laboratory experimentation. Common research areas include:

4.1 Molecular Biology Research

• Peptide structure-function relationship studies
• Gene expression pathway analysis in vitro models
• Protein interaction screening assays

4.2 Biochemistry & Biophysics

• Lipid bilayer interaction studies
• Membrane permeability and binding experiments
• Circular dichroism (CD) spectroscopy analysis
• Mass spectrometry and peptide profiling research

4.3 Immunology Research Models

• Innate immune response simulation systems
• Cell signaling pathway exploration in laboratory models
• Cytokine-related pathway observation in controlled environments

4.4 Microbiology & Biointerface Studies

• Microbial membrane model systems
• Surface interaction and charge dynamics research
• Biofilm-related experimental modeling (non-therapeutic research only)

4.5 Pharmaceutical & Peptide Discovery Research

• Peptide analog development studies
• Structure modification and SAR (structure-activity relationship) research
• Drug delivery system experimental modeling (preclinical stage only)

5. Manufacturing Process

LL-37 is produced using solid-phase peptide synthesis (SPPS) technology, a widely accepted method for high-precision peptide production. The manufacturing process includes:

1. Amino acid sequential coupling
2. Chain elongation under controlled reaction conditions
3. Cleavage and deprotection steps
4. Crude peptide purification
5. High-performance liquid chromatography (HPLC) refinement
6. Lyophilization under sterile, low-moisture conditions
7. Final quality testing and batch validation

Each batch undergoes strict quality control to ensure sequence accuracy, purity consistency, and reproducibility across research applications.

6. Quality Control Standards

Each production batch is tested using analytical methods including:

• HPLC purity analysis
• Mass spectrometry (MS) confirmation
• Amino acid composition verification
• Water content analysis (Karl Fischer method)
• Microbial limit testing (where applicable for research grade materials)

Only batches that meet predefined acceptance criteria are released for distribution.

7. Packaging Information

• Standard vial sizes: 1 mg / 5 mg / 10 mg / 25 mg / 50 mg
• Form: Lyophilized sterile peptide powder
• Primary container: Sterile borosilicate glass vial
• Sealing system: Rubber stopper with aluminum crimp seal
• Secondary packaging: Individual sealed protective foil pouch
• Outer packaging: Laboratory-grade carton box for shipping protection
• Label details: Product name, CAS number, batch number, purity, storage conditions

Custom packaging options are available for bulk laboratory orders.

8. Storage & Handling

To ensure product stability and integrity:

• Store at 2–8°C for short-term use
• For long-term storage, keep at -20°C or below
• Avoid repeated freeze-thaw cycles
• Protect from moisture, heat, and direct light exposure
• Use sterile techniques when handling reconstituted solutions

Proper storage conditions are essential to maintain peptide stability and experimental reliability.

9. Shipping & Stability

The product is shipped under controlled conditions suitable for peptide materials:

• Cold-chain or temperature-controlled packaging available upon request
• Dry ice shipping recommended for long-distance transport
• Stability maintained under lyophilized state during transit
• Fast logistics handling to minimize environmental exposure

Upon receipt, immediate storage under recommended conditions is advised.

10. Intended Use Disclaimer

This product is provided strictly for laboratory research use only. It is not intended for:

• Human consumption
• Veterinary or clinical use
• Diagnostic or therapeutic applications
• Household or personal care use

All handling and usage must be performed by qualified laboratory personnel in appropriate controlled environments.

11. Advantages of This Product

• High purity and consistent batch quality
• Reliable synthetic production process
• Suitable for advanced biochemical research
• Stable lyophilized formulation
• Compatible with a wide range of laboratory techniques
• Strict quality control and documentation support

12. Summary

LL-37 is a well-characterized human peptide widely utilized in scientific research focused on molecular interactions, membrane studies, and cellular signaling models. This product is manufactured under strict quality standards to support reproducible and high-level laboratory investigations.

Its structural uniqueness and biological relevance make it a valuable research tool in peptide science and related experimental fields.