—— Product Specifications ——

—— Product Detail ——

Product Overview

6-bromo-4-chloro-1-methylquinolin-2(1H)-one is a halogenated quinolinone derivative with a molecular formula of C10H7BrClNO. This compound features a quinoline-2-one core structure with strategic bromo and chloro substituents at positions 6 and 4 respectively, along with a methyl group at position 1. The combination of these substituents creates a unique molecular framework that is valuable in pharmaceutical research and development. As a heterocyclic compound, it serves as a key intermediate in the synthesis of various bioactive molecules, particularly those with potential therapeutic applications. The compound is characterized by its well-defined chemical structure and consistent purity levels, making it suitable for research-grade applications in medicinal chemistry and drug discovery programs.

Synthesis Process

The synthesis of 6-bromo-4-chloro-1-methylquinolin-2(1H)-one typically involves a multi-step process starting from appropriate quinoline precursors. The process generally includes halogenation reactions to introduce the bromo and chloro substituents at specific positions on the quinoline ring. Key synthetic steps involve nucleophilic substitution reactions, methylation at the nitrogen position, and careful control of reaction conditions to achieve regioselective halogenation. The final product is isolated through column chromatography and recrystallization techniques to obtain the desired purity level of 95% or higher.

Quality Specifications

This product meets pharmaceutical grade specifications with a minimum purity of 95% as determined by HPLC analysis. The quality specifications include: HPLC purity ≥95%, moisture content <1.0%, residual solvents within ICH limits, heavy metals <10ppm, and individual impurities <0.5%. The compound is characterized by NMR spectroscopy, mass spectrometry, and elemental analysis to confirm identity and purity. Each batch comes with a Certificate of Analysis (CoA) documenting all quality parameters.

Packaging & Storage

The compound is packaged in sealed amber glass bottles or high-density polyethylene (HDPE) containers with tamper-evident closures. Each package is nitrogen-purged to minimize moisture and oxygen exposure. Storage conditions require a cool, dry environment at 2-8°C, protected from light and moisture. The product should be kept in tightly closed containers and handled under inert atmosphere when possible. Shelf life is 24 months when stored under recommended conditions.

—— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.