—— Product Specifications ——

—— Product Detail ——

Product Overview

3-Bromo-5-methoxyquinoline is a quinoline derivative with a bromine substituent at position 3 and a methoxy group at position 5. This heterocyclic compound serves as a crucial pharmaceutical intermediate in drug discovery and development, particularly for anti-infective and anticancer agents. The quinoline scaffold is widely recognized for its diverse biological activities, including antimalarial, antibacterial, and anti-inflammatory properties. The presence of both bromo and methoxy functional groups provides versatile reaction sites for further chemical modifications and structure-activity relationship studies. This compound is typically handled under inert atmosphere and requires careful storage to maintain its chemical integrity and purity.

Synthesis Process

The synthesis of 3-bromo-5-methoxyquinoline typically involves a multi-step sequence starting from 5-methoxyquinoline. Key synthetic routes include bromination at the 3-position using N-bromosuccinimide (NBS) in an appropriate solvent system under controlled temperature conditions. Alternatively, the compound can be prepared through cyclization reactions of appropriately substituted aniline derivatives with proper carbonyl compounds, followed by functional group manipulation to introduce both the bromine and methoxy substituents. The final product is purified through column chromatography or recrystallization to achieve the required purity level. Strict control of reaction parameters including temperature, time, and reagent ratios is essential for optimal yield and selectivity.

Quality Specifications

This product meets Pharmaceutical Grade specifications with a minimum purity of 97% as determined by HPLC. The compound has a melting point range of 108-112°C. Loss on drying is less than 0.5%, and residue on ignition meets specified limits. Mass spectrometry confirms the molecular ion peak at m/z 237-239 (M+), consistent with the expected isotope pattern for bromine. The product is tested for residual solvents and heavy metals, with results conforming to ICH guidelines. Each batch includes a Certificate of Analysis documenting all quality parameters and test methods.

Packaging & Storage

The product is packaged in amber glass bottles with PTFE-lined screw caps, placed within sealed plastic bags with desiccant. For research and development applications, quantities range from 1g to 25g per unit. Storage conditions require a cool (2-8°C), dry environment away from light and moisture. The container should be tightly sealed when not in use to prevent exposure to atmospheric moisture. Under recommended storage conditions, the product maintains stability for 24 months from the manufacturing date.

—— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.