—— Product Specifications ——
| Appearance | Solid powder |
| Assay (HPLC) | ≥99.0% |
| Molecular Formula | C₂₈H₂₈F₂N₆O₃ |
| Molecular Weight | 534.56 g/mol |
| Solubility | Soluble in DMSO; slightly soluble in water |
| Heavy Metals | ≤10 ppm |
| Storage Condition | 2-8°C (short-term) / -20°C (long-term), protect from light |
| Conclusion | Complies with the specification |
—— Product Detail ——
Product Overview
Product Name: Rimegepant
CAS No.: 1289023-67-1
Molecular Formula: C₂₈H₂₈F₂N₆O₃
Molecular Weight: 534.56 g/mol
EINECS No.: 880-367-9
Synonyms: BMS-927711, BHV-3000 , (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
Rimegepant (CAS 1289023-67-1) is a highly potent, orally bioavailable small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist . It appears as a solid powder with a molecular weight of 534.56 and is soluble in DMSO .
With a purity of ≥99.0% by HPLC, Rimegepant demonstrates exceptional binding affinity for the human CGRP receptor with a Ki of 0.027 nM and an IC₅₀ of 0.14 nM . The compound achieves approximately 64% absolute oral bioavailability, distinguishing it from earlier CGRP inhibitors that were restricted to intravenous administration .
Rimegepant was developed by Biohaven Pharmaceuticals and received FDA approval in February 2020 for acute migraine treatment, followed by approval for preventive use in 2021
Key Applications:
1. Migraine Treatment (Primary Application)
Rimegepant is indicated for both acute treatment of migraine with or without aura in adults and prevention of episodic migraine in adults . Unlike traditional triptans, Rimegepant does not constrict blood vessels, making it a safer option for patients with cardiovascular conditions . Clinical trials have demonstrated that a single dose can significantly relieve pain within two hours, with effects lasting up to 48 hours for many patients .
2. Pharmaceutical Research & Drug Development
Rimegepant serves as a valuable reference standard for analytical method development, method validation (AMV), and quality control (QC) applications for Abbreviated New Drug Applications (ANDA) . It is also used in:
-
Formulation development for orally disintegrating tablets (ODTs) and fast-dissolving films
-
In vivo neuropharmacology models for migraine prevention
-
High-sensitivity in vitro receptor binding assays and cryo-EM structural studies
3. Receptor Binding & Pharmacology Studies
With a 2.5x higher binding affinity compared to Ubrogepant (Ki = 0.027 nM vs. 0.067-0.070 nM), Rimegepant is highly suited for competitive ligand-binding assays requiring maximal CGRP receptor blockade at minimal API concentrations .
4. Long-Term Studies & Toxicity Research
Rimegepant demonstrates a 1% probability of drug-induced liver injury (DILI), compared to Telcagepant's 76.1% probability, making it the safe baseline for chronic CGRP inhibition studies
—— Chemical Properties ——
| Property | Value |
| Appearance | Solid powder |
| Molecular Formula | C₂₈H₂₈F₂N₆O₃ |
| Molecular Weight | 534.56 g/mol |
| Density | 1.45±0.1 g/cm³ (20°C, predicted) |
| Solubility | Soluble in DMSO (10 mg/mL), slightly soluble in water |
| Storage Condition | 2-8°C for short-term; -20°C for long-term (months to years) |
| Shelf Life | >2 years if stored properly |
| Sensitivity | Protect from light and moisture |
Packaging & Storage
Available in flexible packaging options: 10mg, 25mg, 50mg, 100mg, 500mg, 1g, 5g, or bulk quantities . Store in a dry, dark place at 2-8°C for short-term use (days to weeks) or at -20°C for long-term storage (months to years) . Protect from light and moisture . Shelf life: 24 months under proper storage conditions.
—— C ompany Profile ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly,we accept usd,.usdt，alipay，wechat pay and cash. If you have other preferred payment methods, we are open to discussion and negotiation.
India
