Manufacturer TB500 Thymosin β4 Acetate CAS 885340-08-9 Cosmetic & Research Grade Lyophilized Peptide

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TB-500 peptide, also known as thymosin β(4), includes a distinct peptide segment (17)LKKTETQ(23), which acts as the active site and which researchers consider potentially impactful in actin binding, cell migration, and wound healing. The amino acid sequence of TB-500 is:
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.

Actins are essential proteins that form a key component of the cytoskeleton within cells, serving not only to maintain cellular structure but also to facilitate various cellular functions, including movement. Actin is suggested to be critical in supporting these cellular structures and processes. Thymosin beta-4 and, thus, TB-500 are believed to interact with actin, potentially by binding to globular actin (G-actin), a precursor to filamentous actin (F-actin). This interaction is thought to hinder the transformation of G-actin into F-actin, a process known as actin

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Brief Introduction of TB500:

TB500 (a synthetic molecule derived from the active domain of thymosin β4) is primarily used in anti-fibrosis and wound repair research. Specific applications include:

1) Tissue Repair and Angiogenesis:

TB500 accelerates wound healing and skin repair by inhibiting the Akt signaling pathway and promoting endothelial cell differentiation, dermal angiogenesis, keratinocyte migration, and collagen deposition.

2) Anti-inflammatory Effects:

Its active ingredients can reduce inflammatory responses, creating a favorable environment for tissue repair.

3) Experimental Research:

TB500 is commonly used in in vitro cell-based assays (such as T cell proliferation and cell survival promotion) and animal model studies. The solvent formulation should be adjusted according to experimental requirements.

※ Note: TB500 is for research use only. Specific applications must adhere to experimental protocols and literature guidance.