Semaglutide (910463-68-2)|99% Purity|Research Grade Peptides|Purity tested by renowned testing laboratories

Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. It is a 31-amino-acid peptide with 94% sequence homology to in vivo GLP-1, engineered with three key modifications: Aib substitution at position 8 for DPP-4 resistance, Arg substitution at position 34, and a C18 fatty diacid side chain attached at Lys26 via a short linker. These modifications enable albumin binding, extending the plasma half-life to approximately 1 week and supporting once-weekly research route application.

As a research reagent, Semaglutide is intended for in vitro and in vivo metabolic research, including studies of obesity, type 2 diabetes, cardiovascular disease, and non-alcoholic steatohepatitis (NASH). The GLP-1 receptor activation provides robust effects on appetite suppression, glucose-dependent insulin secretion, and weight reduction.

• GLP-1 Receptor Activation：Promotes glucose-dependent insulin release from pancreatic beta cells, suppresses glucagon secretion, delays gastric emptying, and reduces appetite through central nervous system pathways.
• DPP-4 Resistance：The Aib substitution at position 8 protects Semaglutide from degradation by dipeptidyl peptidase-4 (DPP-4), significantly extending its biological half-life compared to native GLP-1.
• Albumin Binding：The C18 fatty diacid side chain enables reversible albumin binding in plasma, slowing renal clearance and extending the half-life to approximately 1 week.
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• Obesity & Energy Metabolism Research：In vivo studies of weight regulation, appetite control, and energy expenditure in rodent and primate models
• Type 2 Diabetes Studies：Investigation of glucose homeostasis, insulin secretion, and beta-cell preservation
• Cardiovascular Research：Studies of cardiovascular risk reduction, lipid profiles, and blood pressure
• NASH / NAFLD Research：Evaluation of hepatic steatosis reduction and liver inflammation markers
• Receptor Pharmacology：In vitro characterization of GLP-1 receptor signaling, cAMP assays, and receptor binding studies
• Peptide compound Development：Reference compound for next-generation GLP-1 agonist design and formulation studies

✓ Long-acting GLP-1 receptor agonist with 94% homology to in vivo GLP-1
✓ ≥99% purity verified by HPLC, independently tested by FREEDOM or JANOSHIK
✓ Lyophilized powder in sterile glass vials, 10 vials per box
✓ Available in 5mg, 10mg per vial
✓ Customizable cap colors available for bulk orders

Global Air Shipping · Door-to-Door Delivery

All research reagents are shipped via air freight with professional packaging. Orders dispatch within 3 days, with door-to-door delivery directly to your lab or office.

Shipping Method: Air Freight

Delivery: Door-to-Door

Dispatch Time: Within 3 days of order

Packaging: Professional secure packaging

Customizable Cap Colors

13mm aluminum-plastic caps (6.2mm inner height) with four finish options — matte, glossy, OFF, and tear-off — in 30+ colors. Meet your brand differentiation and product line identification needs.

• Cap Size: 13mm Aluminum-Plastic

• Finishes: Matte / Glossy / OFF / Tear-off

• Colors: 30+ Available

• Packaging: 10 vials / tray / box

* MOQ for custom colors — please consult our sales team.

Precautions

• This product is for research use only 

• Allow vials to equilibrate to room temperature before opening to prevent condensation from affecting product stability

• Reconstitute with appropriate buffer or sterile water according to experimental protocols. Prepare fresh solutions when possible

• Dispose of unused product and packaging in accordance with local regulations for chemical/biological waste.

Q1. How do you ensure product quality?

A1. Each product is independently tested by FREEDOM or JANOSHIK third-party laboratory according to product type, including HPLC purity analysis (≥99%), LC-MS/MS mass spectrometry verification.

Q2. Why buy from us instead of other suppliers?

A2. We are a direct manufacturer offering competitive prices and guaranteed quality. We support customizable cap colors, provide fast air shipping with door-to-door delivery, and deliver honest, timely, and efficient service with extensive experience in domestic and foreign trade. Our products are independently verified by world-class third-party testing laboratories (FREEDOM or JANOSHIK).

Q3. How to place an order?

A3. Contact our sales Lev via WhatsApp (+852 5172 9003) or email (lechumrinhus867@gmail.com) with your requirements including product, size, and quantity. We will send a complete quotation including freight. After confirming the order and receiving payment/deposit, we arrange delivery within 3 days upon receiving the bank receipt.

Q4. Do you have stock?

A4. We keep stock for most standard products and sizes. For some rare products or custom specifications, additional synthesis time is required. Contact our sales team for current stock availability.

Q5. What is your MOQ?

A5.  the minimum order is 1 box (10 vials). Available sizes: 5mg, 10mg, 20mg, 30mg, and 40mg per vial. Larger quantities and custom sizes are available — contact sales for bulk pricing.

Q6. Is there a discount for bulk orders?

A6. Yes, different quantities qualify for different discount tiers. Larger orders always receive better pricing. Contact our sales team for a tailored quotation based on your specific needs.

Q7. Can you provide custom synthesis or modified peptides?

A7. Yes, we offer custom peptide synthesis including sequence modifications, different fatty acid chain lengths, alternative linker chemistries, and various packaging options. Contact our technical team with your specifications for a custom quote.

Advanced Analytical Testing  Sterile Production Process  

Finished Product Quality              Modern R&D Laboratory