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Home > Encyclopedia > PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL structure

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL 

structure
  • CAS No:

    474711-89-2

  • Formula:

    C5H12ClN3O

  • Chemical Name:

    PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL

  • Synonyms:

    PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HYDROCHLORIDE;BUTTPARK 85\04-05;PIPERAZINE-1-CARBOXYLIC ACID AMIDE X HCL;Piperazine-1-carboxamide hydrochloride

  • Categories:

    Pharmaceutical Intermediates  >  Heterocyclic Compound

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Basic Attributes

165.62

165.06700

DTXSID00377840

2933599090

Characteristics

58.4

1.153g/cm3

221-224°C

254.5°C at 760 mmHg

107.7ºC

1.509

Safety Information

IRRITANT

36

26

Xi

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

H302

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Use and Manufacturing

To a solution of tert-butyl4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) in DCM (2 mL) was addeda HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 30 min andconcentrated to give the title compound as a white solid (0.16 g, 100) . The compound 4-carbamoyl-piperazine-1-carboxylate (0.16g, 0.7mmol) was dissolved in dichloromethane(2mL) was added HCl The ethyl acetate solution (4M, 2mL), stirred at rt for 30min, the solvent was removed togive 0.16g of white solid: piperazin-1-carboxamide hydrochloride Salt, yield: 100percent.

Computed Properties

Molecular Weight:165.62
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Exact Mass:165.0668897
Monoisotopic Mass:165.0668897
Topological Polar Surface Area:58.4
Heavy Atom Count:10
Complexity:109
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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