4-Aminomethyltetrahydropyran
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4-Aminomethyltetrahydropyran
structure -
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CAS No:
130290-79-8
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Formula:
C6H13NO
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Chemical Name:
4-Aminomethyltetrahydropyran
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Synonyms:
2H-Pyran-4-methanamine,tetrahydro-;Tetrahydro-2H-pyran-4-methanamine;4-Aminomethyltetrahydropyran;[(Tetrahydro-2H-pyran-4-yl)methyl]amine;[(Tetrahydropyran-4-yl)methyl]amine;1-(Tetrahydro-2H-pyran-4-yl)methanamine;(Tetrahydro-2H-pyran-4-yl)methanamine;4-(Aminomethyl)tetrahydro-2H-pyran;4-(Aminomethyl)-2H-3,4,5,6-tetrahydropyran;Tetrahydro-4-aminomethylpyran;Oxan-4-ylmethanamine;Oxan-4-ylmethylamine;Tetrahydropyran-4-ylmethanamine
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CAS No:
Characteristics
35.2
-0.1
clear colorless liquid
1.02
75 °C
64.9±13.1 °C
1.4630-1.4670
0.912mmHg at 25°C
Safety Information
Ⅲ
IRRITANT
2735
34-41-37/38-22
26-36/37/39-45-39
Xi,C,Xn
Irritant
P260, P264, P270, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P363, P405, P501
H302
|Danger|H302 (55.56%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P272, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 9 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-Aminomethyltetrahydropyran Use and Manufacturing
In an autoclave made of stainless equipped with a stirring device, a thermometer and a pressure gauge and having an inner volume of 200 ml were charged 10.0 g (90.0 mmol) of 4-cyanotetrahydropyran, 100 ml of methanol and 2.0 g (17.0 mmol in terms of a nickel atom) of developed Raney nickel (available from Nikki Chemical Co., Ltd.; sponge nickel N154D), and the mixture was reacted under hydrogen atmosphere (0.51 to 0.61 MPa) at 50 to 60°C for 5 hours under stirring. After completion of the reaction, insoluble materials were filtered, the filtered material was washed with 30 ml of methanol, and the filtrate and the washed solution were combined. When this solution was analyzed by gas chromatography (Internal standard method), 7.19 g (Reaction yield: 52.7percent) of the 4-aminomethyltetrahydropyran was found to be formed. Incidentally, 4.28 g of bis(4-tetrahydropyranylmethyl)amine which is a by-product was formed.4-Cyano-tetrahydropuran(500 mL) in methanolic ammonia (200 mL) was hydrogenated in the presence of Raney nickel (10 g) under a pressure of 4 to 5 kg/cm
Computed Properties
Molecular Weight:115.17
XLogP3:-0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:115.099714038
Monoisotopic Mass:115.099714038
Topological Polar Surface Area:35.2
Heavy Atom Count:8
Complexity:59.5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 4-Aminomethyltetrahydropyran
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CN
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Business licensed Certified factoryManufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED IntermediatesInquiryCAS No.: 130290-79-8Grade: Pharmaceutical GradeContent: 99%
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