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3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE

3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE structure

CAS No:
387350-39-2
Formula:
C7H7F3N2
Chemical Name:
3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE
Synonyms:
(6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)METHANAMINE;3-(Aminomethyl)-6-(trifluoromethyl)pyridine;5-(Aminomethyl)-2-(trifluoromethyl)pyridine;5-(Aminomethyl)-2-(trifluoromethyl)pyridine 97%;C-(6-TrifluoroMethyl-pyridin-3-yl)-MethylaMine;[6-(Trifluoromethyl)pyridin-3-yl]methylamine, 6-(Trifluoromethyl)nicotinylamine;6-(trifluoromethyl)-3-Pyridinemethanamine;5-(Aminomethyl)-2-(trifluoromethyl)pyridine96%
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE Basic Attributes

Molecular Weight：

176.14

Exact Mass：

176.056137

DSSTox ID：

DTXSID10372225

HScode：

2933399090

Characteristics

PSA：

38.9

XLogP3：

0.6

Density：

1.3±0.1 g/cm3

Boiling Point：

62-64°C/0.5mm

Flash Point：

79.2±25.9 °C

Refractive Index：

1.467

Safety Information

hazard class code：

28-37/38-41-43

safety instructions：

26-28-36/37-39-45

Marks：

T+

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE Use and Manufacturing

The product of B (45 mg, 0.13 mmol), (6-(trifluoromethyl)pyridin-3- yl)methanamine (22.89 mg, 0.130 mmol, Matrix) and triethylamine (0.054 mL, 0.39 mmol) werecombined with N, N-dimethylformamide (2 mL), and the mixture was stirred at ambient temperature. 1 -[Bis(dimethylamino)methylene] - 1H- 1 , 2, 3-triazolo[4, 5-b]pyridinium 3-oxid hexafluorophosphate (HATU, 54.4 mg, 0.14 mmol) was added. After stirring for 1 hour, the reaction mixture was filtered through a glass microfiber frit and purified by preparative HPLC [YMC TriArtTM C18 Hybrid 5 jim column, 50 x 100 mm, flow rate 70 mL/minute, 5-100%gradient of acetonitrile in buffer (0.025 M aqueous ammonium bicarbonate, adjusted to pH 10with ammonium hydroxide)] to give the title compound (38 mg, 0.075 mmol, 58 % yield). 1HNMR (501 MHz, DMSO-d6) 5 ppm 8.66 - 8.62 (m, 1H), 8.42 (t, J = 6.0 Hz, 1H), 7.95 (d, J = 8.1Hz, 1H), 7.92 - 7.84 (m, 2H), 7.54 (d, J = 8.9 Hz, 1H), 7.25 (d, J = 2.9 Hz, 1H), 6.98 (dd, J =9.0, 2.9 Hz, 1H), 4.50 (s, 2H), 4.37 (d, J = 5.9 Hz, 2H), 3.63 -3.54 (m, 1H), 2.18 -2.09 (m, 1H), 1.85 - 1.74 (m, 4H), 1.48 - 1.37 (m, 2H), 1.33 - 1.22 (m, 2H); MS (ESf?) m/z 504 (M+H).A solution of

Computed Properties

Molecular Weight:176.14
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:176.05613272
Monoisotopic Mass:176.05613272
Topological Polar Surface Area:38.9
Heavy Atom Count:12
Complexity:146
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

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3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE

CAS No.: 387350-39-2

Grade: industrial Grade

Content: 98%

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Tianjin Jinshu Technology Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of peptone

Professional factory direct supply high quality 99% purity 3-(Aminomethyl)-6-(trifluoromethyl)pyridine

CAS No.: 387350-39-2

Grade: Pharmaceutical Grade

Content: 99%

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Compound Net Biotechnology Inc. Contact Supplier

CN
2 YRS

Business licensed Certified factory

Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

387350-39-2 [6-(trifluoromethyl)pyridin-3-yl]methanamine

CAS No.: 387350-39-2

Grade: Industrial Grade

Content: 95%

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Guide of 3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE

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