(S)-(-)-2-Methyl-2-propanesulfinamide
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(S)-(-)-2-Methyl-2-propanesulfinamide
structure -
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CAS No:
343338-28-3
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Formula:
C4H11NOS
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Chemical Name:
(S)-(-)-2-Methyl-2-propanesulfinamide
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Synonyms:
(S)-(-)-T-BUTYLSULFINAMIDE;TERT-BUTYL SULFINAMIDE;(S)-(-)-t-Butylmethylsulfinamide,min.97%;(S)-(-)-tert-Butyl sulphinamide 98%;(S)-(-)-t-Butyl sulfinamide, 98% ee;(S)-TERT-BUTANESULFINAMIDE / (S)-(-)-2-METHYL-2-PROPANESULFINAMIDE;(S)-(-)-2-METHYL-2-PROPANESULFINAMIDE,98.5+%;(S)-(-)-2-Methyl-2-propanesulfinamide
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Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs
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CAS No:
Characteristics
62.3
0
White Crystalline Powder
1.124
97-101 °C(lit.)
220°C at 760 mmHg
86.8±22.6 °C
1.523
Keep Cold
-4.5 º (c=1, CHCl3)
Safety Information
3
11-19-36/37-40
16-26-36/37-24/25
Xi,Xn,F
store cold
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
(S)-(-)-2-Methyl-2-propanesulfinamide Use and Manufacturing
In the third step, 120 mL of diethoxymethane was added to the reaction flask, and the temperature was controlled between -60 °C and -70 °C. Liquid ammonia (23.8 g, 1.40 mol) was added dropwise to 2.6 mL of 2.3M n-hexyllithium (0.96). Molar), the solution appeared during the process of white solids, incubation reaction 0.5 hours. Then (S)-tert-butylsulfinyl tert-butyl thioester (169.8 g, 0.87 mol, 96.5percent ee) and ethyl chloride (80.4 g, 1.25 mol) were added dropwise to the diethoxymethane solution (by The product solution obtained in the second step was cooled to 0° C. and mixed with ethyl chloride). After the dropwise addition was completed, the reaction was incubated for 1 hour while the reaction was stirred and the reaction was completed. After the reaction solution was evaporated to dryness under reduced pressure, 1400 mL of methyl tert-butyl ether was added, filtered through celite, and the solvent was evaporated. 135 mL of n-heptane was slurried between -10°C and 0°C to obtain fine needle crystals. (3)-tert-butyl Sulfonamide 79.1 g, yield 75percent, HPLC: 99.7percent, 99.4percent ee.
It is also employed as a reagent for synthesizing chiral amines.
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