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Ormetoprim

Ormetoprim structure

CAS No:
6981-18-6
Formula:
C14H18N4O2
Chemical Name:
Ormetoprim
Synonyms:
2,4-Pyrimidinediamine,5-[(4,5-dimethoxy-2-methylphenyl)methyl]-;Pyrimidine,2,4-diamino-5-(6-methylveratryl)-;5-[(4,5-Dimethoxy-2-methylphenyl)methyl]-2,4-pyrimidinediamine;2,4-Diamino-5-(4,5-dimethoxy-2-methylbenzyl)pyrimidine;2,4-Diamino-5-(2-methyl-4,5-dimethoxybenzyl)pyrimidine;Ormetoprim;2,4-Diamino-5-(6-methylveratryl)pyrimidine;2,4-Diamino-5-(2′-methyl-4′,5′-dimethoxybenzyl)pyrimidine;2,4-Diamino-5-(4′,5′-dimethoxy-2′-methylbenzyl)pyrimidine;2,4-Diamino-5-(3,4-dimethoxy-6-methylbenzyl)pyrimidine;Ormethoprim;Ro 5-9754;NSC 95072
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene.

Ormetoprim Basic Attributes

Molecular Weight：

274.32

Exact Mass：

274.32

EC Number：

230-246-6

UNII：

M3EFS94984

NSC Number：

95072

DSSTox ID：

DTXSID1046689

HScode：

29333990

Characteristics

PSA：

96.3

XLogP3：

1.13

Density：

1.3±0.1 g/cm3

Melting Point：

230 °C

Boiling Point：

398.2±52.0 °C at 760 mmHg

Flash Point：

194.6±30.7 °C

Refractive Index：

1.608

Storage Conditions：

0-6°C

Safety Information

safety instructions：

24/25

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

2,4-diamino-5-(6-methylveratryl)pyrimidine

Ormetoprim Use and Manufacturing

It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.

Computed Properties

Molecular Weight:274.32
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:274.14297583
Monoisotopic Mass:274.14297583
Topological Polar Surface Area:96.3
Heavy Atom Count:20
Complexity:305
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Ormetoprim

CAS No.: 6981-18-6

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