Oxychlordane

423.76

423.76

EH9DD6FVT3

DTXSID9044166

12.53000

4.23

2.0±0.1 g/cm3

144 °C

353 °C

165.1±28.8 °C

1.670

0-6°C

LD50 orl-rat: 457 mg/kg NTIS** PB85-143766

III

6.1(b)

2761

22

Xn

H302

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/|Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Oxychlordane was detected in the effluent from 3 pulp mills in Finland at concentrations of 0-130 ng/l(1). Low levels of oxychlordane were detected in the effluent of 2 pulp mills in Finland(2).

Oxychlordane was detected at a concentration of 1 ng/g in the top layer (1 cm) of sediment in a lake in Finland located near a pulp mill(1). Sediment from the South Platte River basin contained oxychlordane at concentrations less than 1 ug/kg(2). Sediment from the St. Lawerence River contained oxychlordane at concentrations of 0.0-1.9 ug/g(3).

Oxychlordane was detected in the ambient atmosphere of Norway at a mean concentration of 0.16 pg/cu-m(1).

Oxychlordane is a metabolic by product of the pesticide chlordane(1). The former production and use of chlordane as a pesticide and termiticide has resulted in the formation of oxychlordane in the environment where chlordane was used(1,SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 8,133(SRC), determined from a structure estimation method(2), indicates that oxychlordane is expected to have no mobility in soil(SRC). Volatilization of oxychlordane is not expected to be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 8.6X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Oxychlordane is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 6.9X10-6 mm Hg(SRC), determined from a fragment constant method(4). Monitoring data has suggested that oxychlordane is persistent in the environment and does not readily biodegrade(5,6).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 8,133(SRC), determined from a structure estimation method(2), indicates that oxychlordane is expected to adsorb to suspended solids and sediment in water(SRC). Oxychlordane is not expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 8.6X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 872 and 6,349, days respectively and adsorption processes may considerably attenuate volatilization(3,SRC). According to a classification scheme(5), an estimated BCF value of 15,878(3,SRC), from an estimated log Kow of 5.83(6,SRC), suggests that bioconcentration in aquatic organisms is very high(SRC). Monitoring data suggests that oxychlordane will bioconcentrate in a variety of aquatic organisms(7,8).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), oxychlordane, which has an estimated vapor pressure of 6.9X10-6 mm Hg at 25 °C(2,SRC), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase oxychlordane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 5(3,SRC) days. Particulate-phase oxychlordane may be physically removed from the air by wet and dry deposition(SRC).

The rate constant for the vapor-phase reaction of oxychlordane with photochemically-produced hydroxyl radicals has been estimated as 3.2X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 5 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Oxychlordane is not expected to undergo hydrolysis or direct photolysis based upon monitoring data that suggests this compound is persistent in the environment(2,3).

An estimated BCF value of 15,878 was calculated for oxychlordane(SRC), using an estimated log Kow of 5.83(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is very high(SRC). Monitoring data has also suggested that bioconcentration in aquatic organisms is high(4,5).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for oxychlordane can be estimated to be about 8,133(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that oxychlordane is expected to have no mobility in soil(SRC).

The Henry's Law constant for oxychlordane is estimated as 8.6X10-8 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that oxychlordane will be essentially nonvolatile from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 872 days(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 6,349 days(2,SRC). Adsorption processes may considerably attenuate volatilization from water surfaces(SRC). Oxychlordane's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces is not expected(SRC). Oxychlordane is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 6.9X10-6 mm Hg(SRC), determined from a fragment constant method(3).

SURFACE WATER: Oxychlordane was detected, not quantified in the Missouri River(1). Oxychlordane was detected in the surface water of Lake Ontario at concentrations of 0.13-0.26 ng/l(2).

Oxychlordane was detected in the beef of a Canadian bison at a concentration of 4 ppb(1). Oxychlordane was detected in infant food composites in the range of 1 ppb and in meat, fish, poultry and dairy substitute products in the range of 0.1 ppb(2). Filleted salmon from Lakes Huron and Michigan contained oxychlordane at concentrations of 1.6-10.8 ug per fillet(3). Filleted carp from Lake Huron contained oxychlordane at an average concentration of 0.6 ug per fillet(3).

Blood and breast milk samples of 16 women were analyzed or polychlorinated biphenyls and some organochlorine pesticides during 8 intervals of a 98 day lactation period. Although a general downward trend in residue levels of blood and breast milk was evident, this trend was interrupted by sporadic increases. Most residues in breast milk showed an apparent increase during the 1st 30 days of lactation, which was not statistically significant. During lactation a statistically significant decr was observed for the following residues, expresssed on a milkfat basis: hexachlorobenzene, oxychlordane, transnonachlor, beta-BHC, p,p'-DDE and p,p'-DDT. Average milk/blood ratios for polychlorinated biphenyls, hexachlorobenzene, oxychlordane, p,p'-DDE, dieldrin and p,p'-DDT levels were 23, 20, 9, 19, 5 and 30, respectively. Milk/blood ratios for polychlorinated biphenyls and p,p'-DDE levels remained relatively constant during lactation (coefficient of variationetically estimated to increase rapidly during the 1st 3 mo of breast feeding, eventually equalling or superseding residue levels in adipose tissue of adult Canadians. No correlation was found between residue levels in milk and blood, whether expressed on a whole or fat basis, but observed p,p'-DDE and polychlorinated biphenyls residue levels in human milk were highly correlated.|A survey of pesticide residues and polychlorinated biphenyls in human milk was analyzed in residents of Hawaii. Milk samples were obtained from 50 donors 3 to 46 days after delivery with a median post partum time of 16 days. A short questionnaire was completed by each donor and information was obtained on age, race, residence, wt of mother, occupation of household members, interval between birth and sample collection, number of children breast fed, smoking habits, dietary habits, occupational and household exposure to pesticides, and use of commercial pest control services. Lipids were extracted from the milk; identification and quantification of the pesticides and polychlorinated biphenyls were performed by electron capture/gas chromatography. All milk samples contained p,p'-DDT, p,p'-DDE, heptachlor epoxide, oxychlordane, hexachlorobenzene, and polychlorinated biphenyls. trans-Nonachlor was found in 98%, dieldrin in 92%, and alpha and beta isomers of hexachlorocyclohexane in 82% of the samples. The mean residue value for p,p'-DDT was 160 ppb and the mean value for p,p'-DDE was 2000 ppb. Mean values for hexachlorocyclohexane, dieldrin, heptachlor epoxide, oxychlordane, hexachlorobenzene, trans-nonachlor, and polychlorinated biphenyls were 86, 42, 35, 59, 40, 81, and 780 ppb, respectively. The amount of pesticides was not associated with age of the mother. The proportion of mothers with high amounts of pesticides was not linearly related to the number of children previously breast fed. The wt of mothers did not affect the excretion of pesticides in milk. Higher pesticide residues were found among donors living in homes treated by professional pest contro operators; the frequency of household use of non persistent pesticides did not affect the concn of pesticides in milk.|Oxychlordane was detected at a mean concentration of 1.6 ppb in human milk in Egypt(1). Oxychlordane was detected in human milk samples obtained from 23 females in Australia at an average concentration of 0.13 ug/g(2). Oxychlordane was detected in 497 samples of human milk in Canada at an average concentration of 0.42 ng/g(3). The average concentration of oxychlordane in Sweedish milk was 0.020 ug/g in 1972 and 0.015 ug/g in 1989(4).

Exposure to oxychlordane may arise from occupations where pesticdes are commonly used(SRC). Blood samples from 567 Florida citrus field workers occupationally exposed to pesticides showed levels of oxychlordane at 311 ppb and 256 ppb during spraying and harvesting seasons respectively(1). Pest control operators in Japan had an average concentration of oxychlordane of 1.4 ppb in blood samples(2). The general population will be exposed to oxychlordane via ingestion of food and drinking water, and dermal contact with food and other products containing oxychlordane(SRC).

Organochlorine insecticides ... do appear in breast milk. /Organochlorines/|A preliminary study was conducted to determine the concn of organochlorine compounds in the adipose tissue of residents of North Texas. Thirty five human adipose tissue samples were obtained during autopsy between 1987 and 1988 from persons who had no known occupational exposure to organochlorine pesticides. These samples were analyzed by electron-capture gas chromatographic methods for the presence of beta-benzene hexachloride, o,p'-DDE, p,p-'DDE, o,p'-DDT, p,p'-DDT, dieldrin, oxychlordane, and heptachlor epoxide. The findings indicate greater than 97% occurence for each compound with the exception of o,p'-DDE and o,p'-DDT, each of which occurred in 54% of the population sampled. Statistical analyses of the data showed strong positive correlations between adipose tissue concn and age for oxychlordane, heptachlor epoxide, p,p'-DDT, p,p'-DDE, and total DDT (the normalized sum of DDT and its analogs) (p: 0.05). Statistically significant differences (p: 0.05) in geometric mean concn between all age groups were found for total DDT and p,p'-DDE. However, the group means comparison test was only significantly different between the 41-60 yr and 61 and over age groups for p,p'-DDT, oxychlordane, and heptachlor epoxide. No statistically significant difference was found between sexes in this study. The geometric means of pesticide concn in adipose tissue were compared with those reported in previous U.S. Environmental Protection Agency surveys for the general population. This comparison clearly indicates a declining temporal trend in environmental exposure for banned DDT analogs; however, a consistent temporal trend exists for oxychlordane and heptachlor epoxide-pesticides whose uses are currently restricted but not proscribed.|Human breast adipose tissues were examined for 13 components and metabolites of technical chlordane. The geometric mean concn of heptachlor epoxide, oxychlordane, and trans-nonachlor were 48, 88, and 120 ng/g of fat, respectively. These concn increased with the subject's age, but were not much different from 1970-1980 values. The nanochlors and the pentachlorocyclopentene chlordanes are the most highly retained compounds in people, whe compared to their abundances in technical people was compared to its accumulation in other mammals, in fishes, and in invertebrates by using a calculated parent/metabolite ratio. The sources of chlordane exposure were evaluated, and it was concluded that exposure to chlordane in indoor air was an important source of these components to the U.S. population.|Blood and breast milk samples of 16 women were analyzed or polychlorinated biphenyls and some organochlorine pesticides during 8 intervals of a 98 day lactation period. Although a general downward trend in residue levels of blood and breast milk was evident, this trend was interrupted by sporadic increases. Most residues in breast milk showed an apparent increase during the 1st 30 days of lactation, which was not statistically significant. During lactation a statistically significant decr was observed for the following residues, expresssed on a milkfat basis: hexachlorobenzene, oxychlordane, transnonachlor, beta-BHC, p,p'-DDE and p,p'-DDT. Average milk/blood ratios for polychlorinated biphenyls, hexachlorobenzene, oxychlordane, p,p'-DDE, dieldrin and p,p'-DDT levels were 23, 20, 9, 19, 5 and 30, respectively. Milk/blood ratios for polychlorinated biphenyls and p,p'-DDE levels remained relatively constant during lactation (coefficient of variationetically estimated to increase rapidly during the 1st 3 mo of breast feeding, eventually equalling or superseding residue levels in adipose tissue of adult Canadians. No correlation was found between residue levels in milk and blood, whether expressed on a whole or fat basis, but observed p,p'-DDE and polychlorinated biphenyls residue levels in human milk were highly correlated.|For more Body Burden (Complete) data for OXYCHLORDANE (7 total), please visit the HSDB record page.

Organochlorines are well absorbed from the lung, GI tract, and skin. /Organochlorines/|The two isomers of chlordane (including its metabolite oxychlordane) accumulate in body fat of animals. The propensity for storage is low. Ratio of storage level in fat to feeding level is about 0.1 in a 30 day feeding trial of chlordane and roughly approaches unity for a chronic 2 year feeding ... .|One important observation made was that the American cockroach readily excretes oxychlordane, in contrast to the rat, which stores it.|The chief route of excretion is biliary, althugh nearly all organochlorines yield measurable urinary metabolites. ... Many of the unmetabolized pesticides are efficiently reabsorbed by the intestine (enterohepatic circulation) substantially retarding fecal excretion. /Solid organochlorine insecticides/|For more Absorption, Distribution and Excretion (Complete) data for OXYCHLORDANE (6 total), please visit the HSDB record page.

IN VIVO & IN VITRO STUDIES IN RATS HAVE REVEALED TWO ROUTES OF BIOTRANSFORMATION OF CHLORDANE & SHOWN THAT THE METABOLITES INCLUDE: TRANS-CHLORDANE, 1,2-DICHLOROCHLORDENE, OXYCHLORDANE, 1-HYDROXY-2-CHLOROCHLORDENE, 1-HYDROXY-2-CHLORO-2,3-EPOXY CHLORDENE, CHLORDENE CHLOROHYDRIN, & 1,2-TRANS-DIHYDROXY DIHYDROCHLORDENE, AS WELL AS METABOLITES OF HEPTACHLOR. IN VITRO STUDIES SHOWED THAT THE LIVER OF RAT & MAN HAVE ALMOST IDENTICAL CAPACITY TO DEGRADE CHLORDANE EXCEPT THAT HUMAN LIVER HAS LITTLE CAPACITY TO CONVERT TRANS-NONACHLOR TO TRANS-CHLORDANE.|... AFTER 15 DAYS ON DIET CONTAINING PURE TRANS-CHLORDANE, RATS OF BOTH SEXES STORED MORE OXYCHLORDANE THAN WHEN FED CIS-ISOMER. ... STORAGE IN FEMALES WAS HIGHER THAN IN MALES. ... 1-EXO-2-ENDO-DICHLOROCHLORDENE WAS ALSO FORMED & DATA INDICATED THAT THIS WAS AN INTERMEDIATE IN OXYCHLORDANE PATHWAY.|GROWING CULTURES OF ACTINOMYCETE (NOCARDIOPSIS SPECIES), WHICH HAD BEEN ISOLATED FROM THE SOIL, METABOLIZED PURE CIS- OR TRANS-CHLORDANE TO AT LEAST 8 SOLVENT-SOL SUBSTANCES INCL DICHLOROCHLORDANE, OXYCHLORDANE, HEPTACHLOR, HEPTACHLOR ENDO-EPOXIDE, CHLORDANE CHLOROHYDRIN, & 3-HYDROXY-TRANS-CHLORDANE. OXYCHLORDANE WAS METABOLICALLY INERT, & ACCUMULATED IN MYCELIUM AS A TERMINAL RESIDUE.|TROPICAL FRESHWATER CICHILDS, CICHLASOMA SPECIES, WEIGHING 300 G EACH, WERE INDIVIDUALLY PLACED IN 16 L OF WATER WITH 80 UG OF CIS-(14)C-CHLORDANE FOR 72 HR. DICHLOROCHLORDENE, OXYCHLORDANE, CHLORDENE CHLOROHYDRIN, DIHYDROXY HEPTACHLOR, DIHYDROXYL DIHYDROCHLORDENE PLUS 4 UNIDENTIFIED COMPOUNDS ACCOUNTED FOR 12.5% OF RADIOCARBON RECOVERED FROM FISH & WATER. REMAINDER WAS UNCHANGED CIS-CHLORDANE.|For more Metabolism/Metabolites (Complete) data for OXYCHLORDANE (9 total), please visit the HSDB record page.

Treatment is symptomatic and supportive. Oils should not be used as either cathartics or dermal cleansing agents, as they increase absorption. Gastric lavage and use of activated charcoal and sodium sulfate are indicated for ingestion. If dermal exposure occurred, contaminated clothes should be removed, and the skin should be thoroughly cleansed with soap and water. Management of seizures in both children and adults is with valium or phenobarbital. Respiratory depression and even respiratory arrest, especially with concomitant use of valium and phenobarbital in children, may occur. These drugs preferably should be used only in critical care areas where emergency endotracheal intubation can be performed. /It is recommended/ that epinephrine not be utilized in patients with organochlorine poisoning, as the organochlorines induce myocardial irritability and ventricular arrhythmias may occur. However, dopamine may be necessary in the event of hypotension unresponsive to fluid administration, and epinephrine may be necessary in the event of cardiopulmonary arrest. /Organochlorine insecticides/|In cases of ingestion, emesis is indicated unless the patient is comatose, is convulsing, or has administration of activated charcoal and saline cathartics. Oil-based cathartics such as castor oil or other substances including fats or oils should be avoided since these compounds may tend to enhance the absorption of the chlorinated hydrocarbon from the gastrointestinal tract. Epinephrine is contraindicated since it may induce ventricular fibrillation due to the sensition of the myocardium by the chlorinated hydrocarbons. Convulsions may be treated with diazepam in a dose of 0.1 mg/kg, administered intravenously, to a maximum of 10 mg. Methods to enhance elimination have not been successful other than as a supportive measure for hepatic and renal failure. /Chlorinated hydrocarbon insecticides/|Seizures, hypoxemia, and resultant acidosis are the immediate life-threatening emergencies. Diazepam is the anticonvulsant of choice. Moderately to severely poisoned patients should have intravenous lines and a cardiac monitor. The usual measures of gut decontamination (ipecac/lavage, charcoal, cathartics) are recommended within the first several hours after exposure. Experimental animal studies suggest that chlorinated hydrocarbon pesticide absorption by charcoal is highly variable. Most organochlorine inseticides contain organic solvents, which are severe aspiration hazards. Skin decontamination (removal of contaminated clothes, washing of area with water and green or mild soap) is necessary to prevent continued dermal absorption. Be careful not to cross-contaminate health personnel. The use of cholestyramine(3-8 g four times a day) increased fecal excretion of chlordecone by seven times and reduced the mean blood half-life from 165 to 80 days. In organochlorine exposures to compounds that have substantial enterohepatic recirculation, activated charcoal also may reduce the half-life and should be considered in serial doses for moderate to severe acute poisonings. Dialysis, diuresis, and hemoperfusion are ineffective because of extensive tissue binding and large volumes of distribution. /Organochlorines/|1. WASH CONTAMINATED SKIN WITH SOAP & WATER. 2. FLUSH CONTAMINATED EYES WITH COPIOUS AMOUNTS OF FRESH WATER FOR 15 MINUTES. 3. INGESTIONS OF SMALL AMOUNTS (LESS THAN 10 MG/KG BODY WEIGHT) OCCURRING LESS THAN AN HOUR BEFORE TREATMENT, ARE PROBABLY BEST TREATED BY: A. SYRUP OF IPECAC, FOLLOWED BY 1-2 GLASSES OF WATER. DOSE FOR ADULTS & CHILDREN OVER 12 YEARS: 30 ML. DOSE FOR CHILDREN UNDER 12 YEARS: 15 ML. B. ACTIVATED CHARCOAL: /SRP: 30 G ACTIVATED CHARCOAL IN 3-4 OZ WATER (CHILDREN), 100 G IN 8-10 OZ WATER (ADULT)/ ... AFTER VOMITING STOPS. C. SODIUM OR MAGNESIUM SULFATE, 0.25 G/KG IN TAP WATER, AS A CATHARTIC. /PESTICIDES OF LOW OR MODERATE TOXICITY/|For more Antidote and Emergency Treatment (Complete) data for OXYCHLORDANE (11 total), please visit the HSDB record page.

Organochlorines are CNS stimulators that produce apprehension, excitability, paresthesias, dizziness, headache, disorientation, and tremor progressing to stupor, coma, and convulsions in severe cases. Organochlorines may enhance myocardial irritability, leading to cardiac dysrhythmias after heavy exposures. Serious complications involve seizures with resultant hypoxemia, severe metabolic acidosis, and death. Intoxication from acute oral exposures generally begins within 45 minutes to several hours. Subacute toxicity has been reported after the extensive and careless use of chlordane over several weeks. Symptoms included paresthesias, anorexia, nausea, fatigue, and malaise. /Organochlorines/|Clinical manifestations following ingestion include apprehension, agitation, vomiting, gastrointestinal upset, abdominal pain, and CNS depression. Convulsions may occur at higher doses and may be preceded by symptoms of ataxia, muscle spasms, and fasciculations. /Chlorinated hydrocarbon insecticides/|SYMPTOMATOLOGY: 1. Earliest signs of poisoning are increased sensitivity to stimuli due to hyperexcitability of the central nervous system, generalized hyperactive reflexes, muscle twitching, tremor, incoordination, ataxia, and clonic convulsions with or without coma. Cycles of excitement and depression may be repeated several times. 2. Liver damage as a possible late manifestation. 3. Anorexia and weight loss. 4. Severe gastroenteritis has been described in one of the fatal human poisonings. /Chlordane/|... SYMPTOMS OF POISONING RESULT FROM STIMULATION OF CNS & INCL HEADACHE, BLURRED VISION, DIZZINESS, SLIGHT INVOLUNTARY MUSCULAR MOVEMENTS, SWEATING, INSOMNIA, BAD DREAMS, NAUSEA, & GENERAL MALAISE. MORE SEVERE ILLNESS IS CHARACTERIZED BY JERKING OF MUSCLES OR GROUPS OF MUSCLES & EPILEPTIFORM CONVULSIONS, WITH LOSS OF CONSCIOUSNESS, INVOLUNTARY INCONTINENCE OF URINE & FECES, DISORIENTATION, PERSONALITY CHANGES, PSYCHIC DISTURBANCES, & LOSS OF MEMORY. SUCH SEIZURES MAY RECUR FOR 2-4 MO AFTER CESSATION OF EXPOSURE & ARE MARKED BY ABNORMAL ENCEPHALOGRAPHIC PATTERNS. /CYCLODIENE INSECTICIDES/|For more Human Toxicity Excerpts (Complete) data for OXYCHLORDANE (11 total), please visit the HSDB record page.

1 alpha,2 beta,4 beta,5,6,7 beta,8,8-octachloro-2,3 alpha-epoxy-3a alpha,4,7,7a alpha-tetrahydro-4,7-methanoindan

Chlordane, the chemical precursor of oxychlordane was banned for use in Japan in 1986.|Chlordane is banned in Argentina, Finland, the German Democratic Republic and the US.

Detection of chlordane and its residues in fresh human blood samples of normal subjects by a highly sensitive analytical technique with a detection limit of 0.01 ppb were reported. Blood donors included 22 male and 21 female healthy medical students, researchers, and office workers of the University of Tokushima. A histogram showed that the concn of each compound exhibited a distribution close to the logarithm of the normal type. Subsequent computations were performed on values obtained by logarithmic conversion. No sex differences in blood levels were found. Significant correlations were found between trans-nonachlor and oxychlordane, between trans-chlordane and cis-chlordane, and between cis-chlordane and cis-nonachlor. Subjects whose homes had been treated for termite control in recent years had high oxychlordane and trans-nonachlor levels. These values were also elevated in the group who indicated that they ate a large amount of fish. Subjects with no likelihood of chlordane exposure had low blood levels of chlordane residues, apparently from food. The authors conclude that oxychlordane and trans-nonachlor appear to be major terminal residues in the blood. Trans-chlordane levels were similarly elevated in blood, but differed in adipose tissue or breast milk. There was a high correlation between the trans-chlordane level and the cis-chlordane and cis-nonachlor levels.|A simplified analytical, procedure was presented for the simultaneous quantification of lindane and chlordane isomers, heptachlor, heptachlor epoxide, oxychlordane, trans-nonachlor, dieldrin, DDT and metabolites. The solid phase chromatography was used for extraction and concn of the chlorinated hydrocarbon pesticides to provide adequate sample preparation and purification prior to the gas chromatographic step. Use of 4 ml of serum provided sensitivity low enough to examine background concn of pesticides in unexposed individuals. The method was reproducible and sufficiently linear to measure these analytes up to 7 ng/ml in an exposed population. The data was currently being collected using a variation of this solid phase extraction procedure for processing fat samples. Extraction efficiency was observed to be from 70 to 75%.