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Sibutramine hydrochloride monohydrate

Sibutramine hydrochloride monohydrate structure

CAS No:
125494-59-9
Formula:
C17H26ClN.ClH.H2O
Chemical Name:
Sibutramine hydrochloride monohydrate
Synonyms:
Cyclobutanemethanamine,1-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-,hydrochloride,hydrate (1:1:1);Cyclobutanemethanamine,1-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-,hydrochloride,monohydrate;Sibutramine hydrochloride monohydrate;1-(1-(4-Chlorophenyl)cyclobutyl)-N,N,3-trimethylbutan-1-amine hydrochloride hydrate
Categories:
Analytical Chemistry > Standard

Description

White SolidSibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-d

Meridia is a DEA Schedule IV controlled substance. Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.

Sibutramine hydrochloride monohydrate Basic Attributes

Molecular Weight：

334.32

Exact Mass：

333.162628

EC Number：

200-659-6

DEA Code Number：

1675

HScode：

2921519090

Characteristics

PSA：

4.2

XLogP3：

5.73 (est)

Appearance：

white

Density：

1.026 g/cm3

Melting Point：

193-195.5 °C

Boiling Point：

342.6ºC at 760 mmHg

Flash Point：

9℃

Water Solubility：

DMSO: >30mg/mL

Storage Conditions：

room temp

Vapor Pressure：

1.14X10-4 mm Hg at 25 deg C (est)

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

36/37/38-39/23/24/25-23/24/25-11

safety instructions：

22-24/25-36-26-45-36/37-16-7

Marks：

Xi,T,F

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

GHS Classification：

|Danger|H301 (97.73%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P272, P280, P281, P285, P301+P310, P302+P352, P304+P341, P305+P351+P338, P308+P313, P314, P321, P330, P333+P313, P337+P313, P342+P311, P363, P405, and P501|Aggregated GHS information provided by 44 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)

MeSH Entry Terms：

(R)-DDMS

DEA Controlled Substances：

Sibutramine|Meridia|1675|Schedule IV - Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.|No

Sibutramine hydrochloride monohydrate Use and Manufacturing

Uses

A serotonin and noradrenaline reuptake inhibitor (SNR).Decreases calorie intake and increases energy expenditure

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:334.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:333.1626199
Monoisotopic Mass:333.1626199
Topological Polar Surface Area:4.2
Heavy Atom Count:21
Complexity:275
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Latest News on Sibutramine hydrochloride monohydrate

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Guide of Sibutramine hydrochloride monohydrate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Latest News
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Sibutramine hydrochloride monohydrate

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