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Butaclamol hydrochloride

Butaclamol hydrochloride structure

CAS No:
36504-94-6
Formula:
C25H31NO.ClH
Chemical Name:
Butaclamol hydrochloride
Synonyms:
1H-Benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-3-ol,3-(1,1-dimethylethyl)-2,3,4,4a,8,9,13b,14-octahydro-,hydrochloride (1:1),(3R,4aR,13bR)-rel-;1H-Benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-3-ol,3-(1,1-dimethylethyl)-2,3,4,4a,8,9,13b,14-octahydro-,hydrochloride,(3α,4aα,13bβ)-(±)-;1H-Benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-3-ol,3-(1,1-dimethylethyl)-2,3,4,4a,8,9,13b,14-octahydro-,hydrochloride,(3R,4aR,13bR)-rel-;Butaclamol hydrochloride;(±)-Butaclamol hydrochloride;AY 23028;dl-Butaclamol hydrochloride;1H-Benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-3-ol,3-(1,1-dimethylethyl)-2,3,4,4a,8,9,13b,14-octahydro-,hydrochloride,(3α,4aα,13bβ)-;AY 23038
Categories:
Analytical Chemistry > Standard

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Description

A benzocycloheptapyridoisoquinolinol that has been used as an antipsychotic, especially in schizophrenia.

Butaclamol hydrochloride Basic Attributes

Molecular Weight：

397.987

Exact Mass：

361.24100

DSSTox ID：

DTXSID0045757

Characteristics

PSA：

23.47000

XLogP3：

4.78270

Density：

1.16g/cm3

Boiling Point：

500.3ºC at 760mmHg

Flash Point：

239.9ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

DE8039700

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

MeSH Entry Terms：

AY 23,028

Butaclamol hydrochloride Use and Manufacturing

Antipsychotic.

Computed Properties

Molecular Weight:398.0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:397.2172423
Monoisotopic Mass:397.2172423
Topological Polar Surface Area:23.5
Heavy Atom Count:28
Complexity:553
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes