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Glafenine

Glafenine structure

CAS No:
3820-67-5
Formula:
C19H17ClN2O4
Chemical Name:
Glafenine
Synonyms:
Benzoic acid,2-[(7-chloro-4-quinolinyl)amino]-,2,3-dihydroxypropyl ester;Anthranilic acid,N-(7-chloro-4-quinolyl)-,2,3-dihydroxypropyl ester;Glycerol,1-[N-(7-chloro-4-quinolyl)anthranilate];R 1707;4-[2-(β,γ-Dihydroxypropoxycarbonyl)phenylamino]-7-chloroquinoline;2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl)anthranilate;Glaphenine;Glifanan;Glycerylaminophenaquine;Glafenine;Glaphenin;2,3-Dihydroxypropyl-N-(7-chloro-4-quinolinyl)anthranilate;N-(7-Chloro-4-quinolyl)anthranilic acid 2,3-dihydroxypropyl ester;4-[(2-Carboxyphenyl)amino]-7-chloroquinoline α-monoglyceride;2-[(7-Chloro-4-quinolyl)amino]benzoic acid α-glyceride;Glifan;Alcidon;Dolomate;Glafenin;Glicafan;Glifanar;Privadol;2,3-Dihydroxypropyl 2-((7-chloroquinolin-4-yl)amino)benzoate
Categories:
Analytical Chemistry > Standard

Description

Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins.

Glafenine is a carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market. It has a role as a non-narcotic analgesic, a non-steroidal anti-inflammatory drug and an inhibitor. It is an organochlorine compound, a secondary amino compound, a glycol, a carboxylic ester and an aminoquinoline. It derives from a glycerol and an anthranilic acid.|An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.

Glafenine Basic Attributes

Molecular Weight：

372.81

Exact Mass：

372.80

EC Number：

223-315-7

NSC Number：

757808

DSSTox ID：

DTXSID1048546

ATC Code：

N - Nervous system

HScode：

2933499090

Characteristics

PSA：

91.68000

XLogP3：

3.21480

Density：

1.428g/cm3

Melting Point：

169.5 °C

Boiling Point：

618℃

Flash Point：

328℃

Refractive Index：

1.696

Water Solubility：

38.46g/L(temperature not stated)

Toxicity：

LD50 orally in mice: >2 g/kg (Allais, Meier)

Collision Cross Section：

187.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

CB2687000

Marks：

Drug Information

MeSH：

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

MeSH Entry Terms：

Exidol

Glafenine Use and Manufacturing

Glafenine is a non-narcotic analgesic agent. Glafenine shows significant antiinflammatory activity. Glafenine is widely used for the treatment of pains of various origins.

Computed Properties

Molecular Weight:372.8
XLogP3:3.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:372.0876847
Monoisotopic Mass:372.0876847
Topological Polar Surface Area:91.7
Heavy Atom Count:26
Complexity:467
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes