Iodofenphos

413

413.00

242-069-1

SME6G1846X

DTXSID8040278

COLORLESS CRYSTALS|CRYSTALLINE POWDER|Pale yellow oil, solidifies to crystals

29201900

59.8

5.51

2.0 g/cm³ @ Temp: 20 °C

72-73 °C

30.1°C

181.0±30.7 °C

1.624

soluble in acetone, xylene. Slightly soluble in alcohol, soluble in water

APPROX 4°C

8.25X10-7 mm Hg at 20 deg C

Oral-Rat LD50: 2330 mg/kg; Oral-Mouse LD50: 3000 mg/kg

Combustion produces toxic chloride, iodide, sulfur oxide and phosphorus oxide gas

MILD ODOR

Noncorrosive

UN28116.1/PG3

21-50/53

36/37-60-61

TF0175000

Xn,N

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

JODFENFOS IS RELATIVELY STABLE IN NEUTRAL OR WEAKLY ACIDIC OR ALKALINE MEDIA BUT UNSTABLE IN CONCENTRATED ACIDS & ALKALIES.

P273-P280-P312

H311-H400

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|All organic pesticides, whether of botanical or synthetic origin, can be destroyed by incineration. /Organic pesticides/|Manufacturers or formulators of very large amounts of pesticides may find it advantageous to build incinerators adequate to destroy all organic pesticides and equipped with scrubbers to remove acid wastes. /Organic pesticides/

|Danger|H311 (92.68%): Toxic in contact with skin [Danger Acute toxicity, dermal]|P273, P280, P302+P352, P312, P322, P361, P363, P391, P405, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/|WORKERS HANDLING AND APPLYING ORGANOPHOSPHATE PESTICIDES (OPP) MUST ... BE GIVEN PERSONAL PROTECTIVE EQUIPMENT COMPRISING OVERALLS MADE OF A TIGHT FABRIC OR POLYVINYL CHLORIDE, GLOVES, AND RUBBER BOOTS. THEY MUST WEAR A RESPIRATOR WITH AN ACTIVATED-CARBON GAS FILTER CARTRIDGE AFFORDING PROTECTION FOR A DETERMINED NUMBER OF WORKING HOURS. THE EYES SHOULD BE PROTECTED BY GOGGLES. THE SIGNALMEN FOR AERIAL DUSTING OPERATIONS SHOULD BE EQUIPPED WITH A HAT AND CAPE MADE OF POLYVINYL CHLORIDE OR A FABRIC IMPREGNATED WITH A WATER REPELLENT. /PESTICIDES, ORGANOPHOSPHORUS/

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, liquid, NOS/|If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, solid, NOS/

In some situations where personnel may become accidently contaminated ... it is necessary to provide shower bath in addition to the usual washing facilities. Special arrangements for cleaning clothing & overalls may be necessary ... /Pesticides/|Special aircraft should preferably be used for spraying or dusting toxic organophosphorus pesticides. ... aerial spraying or dusting gives rise to clouds which spread over larger surfaces than clouds produced by ground application. Aerial spraying should therefore be carried out on windless days only. Residential areas, water supply sources, etc must be avoided. ... When aircraft approaches, signalmen /guiding the aircraft/ should leave the windward side. ... The local population should be informed about the site & time of aerial pesticide treatment. Access of unauthorized persons & especially children to the area to be treated must be ... forbidden. Warning signs should be placed at the limits of the area. Ground spraying must be carried out with compressed-air spraying equipment towed by tractors with closed cabs. /Organophosphorus pesticides/|Small packages of pesticides are preferable for individual application in order to limit the quantities to be weighed & metered. A special vessel with long stirring rod for dilution & suspension of the poison must be available in order to reduce manual handling to a minimum. The strict observance of hygiene rules--no smoking & no food intake during work. Thorough washing with soap after work, changing protective clothing before going home--is of utmost importance. /Organophosphorus pesticides/|Containers ... should be cleaned with a suspension of bleaching powder in water or with other alkaline soln after soaking for 24 hr and then be rinsed with hot water. /Organophosphorus pesticides/|For more Preventive Measures (Complete) data for IODOFENPHOS (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

moderately toxic

Some phenothiazines may antagonize & some may potentiate the toxic anticholinesterase effects of ... /organophosphorus insecticides/. /Organophosphate cholinesterase inhibitors/|In long term therapy, adrenocorticoids antagonize the antiglaucoma effects of anticholinesterases (incr ocular pressure). ... Anticholinergics antagonize the miotic (antiglaucoma) & other muscarinic effects of anticholinesterases on the autonomic & central nervous systems. Tricyclic antidepressants (anticholinergic effects) antagonize the antiglaucoma (miotic) effects of anticholinesterases in glaucoma. ... Antihistamines with anticholinergic effects antagonize the miotic (antiglaucoma) & CNS effects of anticholinesterases. Anticholinesterases potentiate tranquilizing & behavioral changes induced by antihistamines. The actions of anticholinesterase agents on autonomic effector cells, & to some extent those on CNS, are antagonized by atropine, an antidote of choice. Barbiturates are potentiated by anticholinesterases. ... Dexpanthenol potentiates the effects of anticholinesterases. Fluorophosphate insecticides potentiate the effects of other anticholinesterases. /Anticholinesterases/|BARBITURATES ARE POTENTIATED BY ANTICHOLINESTERASES. ALTHOUGH BARBITURATES MAY BE USED CAUTIOUSLY IN TREATING CONVULSIONS, EXTREME CARE IS ESSENTIAL IN HANDLING POISONINGS DUE TO ANTICHOLINESTERASES, PARTICULARLY ORGANOPHOSPHORUS PESTICIDES. ECHOTHIOPHATE, A CHOLINESTERASE INHIBITOR USED AS MIOTIC, POTENTIATES OTHER SUCH INHIBITORS ... USED FOR OTHER PURPOSES (ADDITIVE EFFECTS) OR POSSIBLY SYNERGISTIC. THOSE EXPOSED TO ORGANOPHOSPHATE INSECTICIDES MUST TAKE STRICT PRECAUTIONS. ... ORGANOPHOSPHORUS INSECTICIDES: ADDITIVE ANTICHOLINESTERASE EFFECTS. HAZARDOUS. PATIENTS ON ANTICHOLINESTERASES (EVEN TOPICAL, SUCH AS EYE DROPS) SHOULD AVOID AREAS WHERE ORGANOPHOSPHORUS INSECTICIDES ... RECENTLY ... USED. /ANTICHOLINESTERASE/|ANTICHOLINESTERASE (ORGANOPHOSPHORUS) INSECTICIDES ANTAGONIZE POLARIZING MUSCLE RELAXANTS. PHENOTHIAZINES /AND THIOXANTHENES/: ... MAY ENHANCE TOXIC EFFECTS OF ORGANOPHOSPHORUS INSECTICIDES. /INSECTICIDES, ORGANOPHOSPHORUS/

Work ... must not be carried out by young persons under 18 yr, expectant or nursing mothers, or persons for whom work with toxic chemicals is contraindicated on account of their state of health; the same applies to alcoholics. Contraindications for work with organophosphorus pesticides are organic diseases of the CNS, mental disorders & epilepsy, pronounced endocrine & vegetative disorders, pulmonary tuberculosis, bronchial asthma, chronic respiratory diseases, cardiovascular diseases and circulatory disorders, gastrointestinal diseases (peptic ulcer), gastroenterocolitis, diseases of the liver & kidneys, eye diseases (chronic conjunctivitis and keratitis). /Organophosphorus pesticides/

Iodofenphos's former use(1) as a contact and stomach insecticide and acaricide for control of flies and mosquitoes in public hygiene, indoor pests such as ants, bedbugs, cockroaches, fleas and warehouse pests(2) has resulted in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 24,000(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(3), suggests that iodofenphos will be immobile in soil(SRC). Iodofenphos had measured half-lives of 70.5 and 85.1 days in illuminated and non-illuminated soil, respectively(4). The main degradation product was 2,5-dichloro-4-iodophenol indicating that the main decomposition reaction was the cleavage of the aryl ester bond(4). Degradation was due to both abiotic and biotic reactions. Volatilization of iodofenphos is not expected to be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 4.5X10-6 atm-cu m/mole(SRC), determined from experimental values for vapor pressure(5) and water solubility(6). Volatilization from dry soil surfaces(SRC) is not expected based on a measured vapor pressure of 8.25X10-7 mm Hg(5).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 24,000(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(1), suggests that iodofenphos will adsorb to suspended solids and sediment in water(SRC). Half-lives of 0.4 and 1.9 days were measured for iodofenphos in illuminated and non-illuminated rainwater, respectively(3). The main degradation product was 2,5-dichloro-4-iodophenol indicating that the main decomposition reaction was the cleavage of the aryl ester bond(3). Degradation was due to both abiotic and biotic reactions. Iodofenphos is not expected to volatilize from water surfaces based on an estimated Henry's Law constant of 4.5X10-6 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure(4) and water solubility(5). Estimated half-lives for a model river and model lake are 17 and 130, respectively(1,SRC), although adsorption to particulate matter may attenuate the volatilization of this compound from water surfaces(SRC). An estimated BCF value of 9000(1,SRC), from an estimated log Kow(2,SRC), and a BCF of 48,000, measured in guppies(6), indicate that iodofenphos will bioconcentrate in aquatic organisms(SRC), according to a recommended classification scheme(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), iodofenphos, which has a measured vapor pressure of 8.25X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase iodofenphos is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 7 hours(3,SRC). Particulate-phase iodofenphos may be physically removed from the air by dry deposition(SRC).

The rate constant for the vapor-phase reaction of iodofenphos with photochemically produced hydroxyl radicals has been estimated as 5.6X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 7 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The photolysis of iodofenphos was studied using artificial sunlight and a day/night rhythm for a period of 96 days. Half-lives of 0.4 and 1.9 days were measured for iodofenphos in illuminated and non-illuminated rainwater, respectively(2). Iodofenphos had measured half-lives of 70.5 and 85.1 days in illuminated and non-illuminated soil, respectively(2). The main degradation product was 2,5-dichloro-4-iodophenol indicating that the main decomposition reaction was the cleavage of the aryl ester bond(2). Degradation was due to both abiotic and biotic reactions.

4.17e+03|An estimated BCF value of 9000 was calculated for iodofenphos(SRC), using a measured log Kow of 5.51(1) and a recommended regression-derived equation(2). Guppies, Poecilia reticulata, exposed to a mixture of cyanophos, methylparathion, ronnel, fenitrothion, dicapthon, and iodofenphos had a bioconcentration factor of 48,000 for iodofenphos; an elimination rate constant of 0.36/day was observed for the same compound(3). According to a recommended classification scheme(4), these values indicate a very high BCF, and that short-term bioaccumulation will occur(SRC) based on a measured elimination rate in aquatic organisms(3).|Biotransformation of a series of organophosphorus compounds by the 9,000 g supernatant of rainbow trout (Oncorhynchus mykiss) liver was tested in an in vitro system fortified either with NADPH-generating cofactors or with reduced glutathione. Elimination rate constants for both systems were calculated from linear decay curves when substrate concentrations were used that were considerably lower than the Km values of the concerned enzymatic reactions. The results reveal a large variation in both the oxidative and the glutathione-mediated biotransformation rate of the organophosphorus compounds. Half-lives ranged from 25 to 1,216 min in the NADPH system and from 18 to 381 min in the glutathione system. Elimination rate constants in the glutathione system were related to Hammett sigma constants or reactivity toward 4-nitrobenzylpyridine, which substantiates the assumption that electrophilicity is the controlling variable for the reaction with glutathione within this particular class of compounds. A remarkable analogy was observed between compounds that were metabolized relatively quickly by glutathione S-transferases and compounds that showed a reduced bioconcentration factor in guppies. A significant improvement of the relationship between the bioconcentration factor in guppies and the octanol/water partition coefficient was obtained when the rate constant with glutathione was introduced in this relationship. Such an improvement was not obtained with the rate constants from the oxidative system. These observations are discussed in view of the differences in the activities of the involved enzyme systems in the test species and in view of the possible relevance of the different biotransformation pathways for the in vivo situation.

The Koc of iodofenphos is estimated as approximately 24,000(SRC), using a measured log Kow of 5.51(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that iodofenphos will be immobile in soil(SRC).

The Henry's Law constant for iodofenphos is estimated as 4.5X10-6 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 8.25X10-7 mm Hg(1), and water solubility, 0.10 mg/l(2). This value indicates that iodofenphos will slowly volatilize from water surfaces(3,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 17 days(3,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 130 days(3,SRC). Iodofenphos's values for vapor pressure(1) and Henry's Law constant(1,2,SRC) indicate that volatilization from dry and moist soil surfaces is not expected to be an important environmental fate(SRC).

SURFACE WATER: Surface waters in the Hogeveense Polder, The Netherlands, sampled from August 1989-January 1990, contained from 0.2 to 0.4 ug/l iodofenphos(1).

Occupational exposure to iodofenphos may be through ingestion and inhalation of vapors or droplets, or by absorption through the skin(1).

IT ... PENETRATES INTO PLANT TISSUES.|OVER 80% OF IODOFENPHOS ADMIN TO RAT WAS ELIMINATED IN 24 HR IN URINE.|Ninety-two percent of (32)P-iodofenfos was eliminated by rats within 24 hours after an oral dose. A trace of iodofenoxon was found in the urine, but over 98% of the total radioactivity in the urine was in the form of metabolites.|Most organophosphate compounds are ... absorbed from skin, conjunctiva, gastrointestinal tract, & lung. /Organophosphate compounds/|For more Absorption, Distribution and Excretion (Complete) data for IODOFENPHOS (9 total), please visit the HSDB record page.

OVER 80% OF IODOFENPHOS ADMIN TO RAT WAS ELIMINATED IN 24 HR IN URINE. IN ADDITION TO FIVE UNIDENTIFIED METABOLITES, IODOFENOXON, DESMETHYL IODOFENOXON, MONO- & DI-METHYL PHOSPHORIC ACID, PHOSPHORIC ACID, & DIMETHYL PHOSPHOROTHIOIC ACID WERE FOUND IN URINE.|AFTER INJECTION OF IODOFENPHOS INTO TOMATO PLANTS, /ONE/ OXYGEN ANALOG WAS DETECTED IN LEAVES BUT NOT IN STEMS.|The metabolism of the organophosphorus insecticide ... iodofenphos ... in rain water was studied under artificial sunlight and in darkness. During degradation experiments several parameters (eg concentration of the water samples, temperature, time of erradiation) were strictly controlled. The polar metabolites showing an inhibition of cholinesterase were detected by a highly sensitive enzymatic inhibition method.|Treatment of an Angora goat with iodofenphos produced some 4-iodophenol in the urine only.|For more Metabolism/Metabolites (Complete) data for IODOFENPHOS (7 total), please visit the HSDB record page.

7.24 Days

Cholinesterase inhibitor.|The cardiovascular actions of anticholinesterase agents are complex, since they reflect both ganglionic and postganglionic effects of accumulated ACh on the heart and blood vessels. The predominant effect on the heart from the peripheral action of accumulated ACh is bradycardia, resulting in a fall in cardiac output. Higher doses usually cause a fall in blood pressure, often as a consequence of effects of anticholinesterase agents on the medullary vasomotor centers of the CNS. /Anticholinesterase agents/|Organophosphorus derivatives act by combining with and inactivating the enzyme acetylcholinesterase. ... The inactivation of cholinesterase by cholinesterase inhibitor pesticides allows the accumulation of large amounts of acetylcholine, with resultant widespread effects that may be ... separated into 4 categories: (1) Potentiation of postganglionic parasympathetic activity. ... (2) Persistent depolarization of skeletal muscle ... (3) Initial stimulation following depression of cells of central nervous system ... (4) Variable ganglionic stimulation or blockade ... /Cholinesterase inhibitor pesticides/|The main feature of the toxic mechanism of organophosphorus pesticides is inhibition of the esterase enzyme activity, in particular of cholinesterase, which plays an important physiological part. Organophosphorus pesticides can also indirectly interact with the biochemical receptors of acetylcholine. /Organophosphorus pesticides/|For more Mechanism of Action (Complete) data for IODOFENPHOS (7 total), please visit the HSDB record page.

A comatose patient who is diaphoretic, has pinpoint pupils and the odor of an insecticide on clothing or breath, and is noted to have muscle fasciculations represents the classic presentation of organophosphate poisoning. ... Specific steps in management include the following. 1. Decontamination. ... 2 Airway. Establish an airway if necessary. ... 3. Respiratory Status. Respiratory distress, in fact, is commonly found in these patients from multiple causes. ... 4. Cardiac Monitoring. ... 5. Cholinesterase Level. ... 6. Pralidoxime. Pralidoxime is the treatment of choice for organophosphate poisoning and should be used for nearly all patients with clinically significant orgnophosphate poisoning, particularly whose patients with muscular fasciculations and weakness. ... 7. Atropine. Atropine is the physiologic antidote for organophosphate poisoning. A trial dose of atropine should be instituted on clinical ground when one suspects organophosphate intoxication. /Organophosphate poisoning/|1. INSURE THAT A CLEAR AIRWAY EXISTS BY ASPIRATION OF SECRETIONS IF NECESSARY. ADMIN OXYGEN BY MECHANICALLY ASSISTED PULMONARY VENTILATION IF RESPIRATION IS DEPRESSED. IMPROVE TISSUE OXYGENATION AS MUCH AS POSSIBLE BEFORE ADMIN ATROPINE TO MINIMIZE RISK OF VENTRICULAR FIBRILLATION. IN SEVERE POISONINGS, IT MAY BE NECESSARY TO SUPPORT PULMONARY VENTILATION MECHANICALLY FOR SEVERAL DAYS. 2. ADMIN ATROPINE SULFATE IV, OR IM IF IV INJECTION IS NOT POSSIBLE. ... IN MODERATELY SEVERE POISONING: ADULT DOSAGE AND CHILDREN OVER 12 YR: 0.4-2.0 MG REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED. MAINTAIN ATROPINIZATION WITH REPEATED DOSAGE OF 0.02-0.05 MG/KG BODY WEIGHT. /ORGANOPHOSPHATE PESTICIDES/|2. SEVERELY POISONED INDIVIDUALS MAY EXHIBIT REMARKABLE TOLERANCE TO ATROPINE; TWO OR MORE TIMES THE DOSAGES SUGGESTED ABOVE MAY BE NEEDED. THE DOSE OF ATROPINE MAY BE INCREASED AND THE DOSING INTERVAL DECREASED AS NEEDED TO CONTROL SYMPTOMS. CONTINUOUS INTRAVENOUS INFUSION OF ATROPINE MAY BE NECESSARY WHEN ATROPINE REQUIREMENTS ARE MASSIVE. REVERSAL OF MUSCARINIC SYMPTOMS AND SIGNS, NOT AN ARBITRARY DOSE LIMIT, IS THE DESIRED END-POINT. PRESERVATIVE-FREE ATROPINE PRODUCTS SHOULD BE USED WHENEVER POSSIBLE. NOTE: PERSONS NOT POISONED OR ONLY SLIGHTLY POISONED BY ORGANOPHOSPHATES MAY DEVELOP SIGNS OF ATROPINE TOXICITY FROM SUCH LARGE DOSES. FEVER, MUSCLE FIBRILLATIONS, AND DELIRIUM ARE THE MAIN SIGNS OF ATROPINE TOXICITY. IF THESE APPEAR WHILE THE PATIENT IS FULLY ATROPINIZED, ATROPINE ADMINISTRATION SHOULD BE DISCONTINUED, AT LEAST TEMPORARILY, WHILE THE SEVERITY OF POISONING IS REEVALUATED. /ORGANOPHOSPHATE PESTICIDES/|3. DRAW BLOOD SAMPLE (HEPARINIZED) FOR CHOLINESTERASE ANALYSIS BEFORE ADMINISTRATION OF PRALIDOXIME, WHICH TENDS TO REVERSE THE CHOLINESTERASE DEPRESSION. 4. ADMIN PRALIDOXIME (PROTOPAM, 2-PAM) IN CASES OF SEVERE POISONING...IN WHICH RESP DEPRESSION, MUSCLE WEAKNESS & TWITCHINGS ARE SEVERE. ... ADULT DOSAGE AND CHILDREN OVER 12): GIVE 1.0-2.0 G IV @ NO MORE THAN 0.2 G/MIN. CHILD'S DOSE (UNDER 12 YR): GIVE 20-50 MG/KG (DEPENDING ON SEVERITY) IV, INJECTING NO MORE THAN HALF TOTAL DOSE/MIN. DOSAGE...MAY BE REPEATED IN 1-2 HR, THEN @ 10-12 HR INTERVAL IF NEEDED. IN VERY SEVERE POISONINGS, DOSAGE...MAY BE DOUBLED. /ORGANOPHOSPHATE PESTICIDES/|For more Antidote and Emergency Treatment (Complete) data for IODOFENPHOS (9 total), please visit the HSDB record page.

Five sprayers and one mixer applied 50% water-wettable iodofenfos powder as a 5% suspension of active ingredient at an intended rate of 2 gm/sq m. They treated a village of 874 homes and 412 other structures. Most of the walls were of mud and the roofs of thatch. The work required 5 to 6 hr/day for 8 days. No complaints attributed to the insecticide were elicited from the 6 workers or the 1819 inhabitants of the village. There was no significant depression of whole-blood cholinesterase among the workers or among over 30 inhabitants who were tested 1 and 10 days after spraying.|All the organophosphorus insecticides have a cumulative effect by progressive inhibition of cholinesterase ... /Organophosphorus insecticides/|The symptoms of chronic poisoning due to organophosphorus pesticides include headache, weakness, feeling of heaviness in head, decline of memory, quick onset of fatigue, disturbed sleep, loss of appetite, & loss of orientation. Psychic disorders, nystagmus, trembling of the hands & other nervous system disorders can be observed in certain cases. Sometimes neuritis, paresis & paralysis develop. /Organophosphorus pesticides/|Organophosphorus cmpd can produce dermal irritation but most are weak sensitizers. /Organophosphate cmpd/|For more Human Toxicity Excerpts (Complete) data for IODOFENPHOS (18 total), please visit the HSDB record page.

Alfacron

'NUVANOL N' WP, WETTABLE POWDER (500 G AI/KG); 'NUVANOL N' 500 FW, SUSPENSION CONCENTRATE (500 G/L); 'NUVANOL N' 20 U, EMULSIFIABLE CONCENTRATE (200 G/L); 'NUVANOL N' 5 P READY-TO-USE POWDER (50 G/KG). PRODUCTS SOLD UNDER TRADE MARK 'ALFACRON' ARE NO LONGER AVAILABLE.|Mixed formulations: Iodofenphos + Dichlorvos.|ALFACRON|C 9491|For more Formulations/Preparations (Complete) data for IODOFENPHOS (14 total), please visit the HSDB record page.

2-Propenamide, N-[3-(dimethylamino)propyl]-2-methyl-, polymer with 1-ethenyl-2-pyrrolidinone, sulfate: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.|The WHO Recommended Classification of Pesticides by Hazard identifies Iodofenphos (technical grade) as an active ingredient believed to be obsolete or discontinued for use as a pesticide.|INTRODUCED /IN 1966/ BY CIBA AG (NOW CIBA-GEIGY AG) (BELGIAN PATENT 672431; BRITISH PATENT 1057609) AS CODE NUMBER 'C9491'; TRADE MARK 'NUVANOL N'.|Miscible with other neutral, powder-formulated insecticides.|Nuvanol N is not marketed in the USA|For more General Manufacturing Information (Complete) data for IODOFENPHOS (6 total), please visit the HSDB record page.

THE ACTIVE INGREDIENT /IS/ SEPARATED BY TLC, HYDROLYZED TO DICHLOROIODOPHENOL & ASSESSED BY UV SPECTROSCOPY. RESIDUES ARE DETERMINED BY GAS-LIQUID CHROMATOGRAPHY USING ELECTRON-CAPTURE OR PHOSPHORUS-SPECIFIC FLAME PHOTOMETRIC DETECTOR. PARTICULARS ARE AVAILABLE FROM CIBA-GEIGY LTD, BASLE.|Residues may be determined by ... conversion to phosphate which is measured by standard colorimetric methods.|The metabolism of the organophosphorus insecticide ... iodofenphos ... in rain water was studied under artificial sunlight and in darkness. During degradation experiments several parameters (eg concentration of the water samples, temperature, time of irradiation) were strictly controlled. The polar metabolites showing an inhibition of cholinesterase were detected by a highly sensitive enzymatic inhibition method. The elution of low quantities of polar substances from polyamide layers for MS identification is a method that involves a high risk of loss of the sample under study . Therefore, the compounds were introduced directly into the ion source of the mass spectrometer, together with a large excess of polyamide. Excellent mass spectra were obtained with no interference from the polyamide. Polar metabolites were easily separated and identified in nanogram quantities. The great advantage of enzymatic inhibition detection and TLC/MS without substance elution is the high sensitivity (ng) of both methods.|FDA Method 232.4. Organophosphorus Residues General Methods for Nonfatty Foods Using Acetone Extraction and Isolation in the Organic Phase. GC/ECD method.|For more Analytic Laboratory Methods (Complete) data for IODOFENPHOS (6 total), please visit the HSDB record page.

A GLC PROCEDURE USING A FLAME PHOTOMETRIC DETECTOR IS DESCRIBED FOR DETERMINING RESIDUES OF IODOFENPHOS IN TISSUE AND URINE OF CATTLE.|A METHOD FOR DETERMINING PHENOLIC PESTICIDE METABOLITES IN URINE BY LIQUID CHROMATOGRAPHY IS DESCRIBED. THE METHOD HAS THE CAPABILITY FOR ASSESSING HUMAN EXPOSURE TO IODOFENPHOS.

Agrochemicals -> Insecticides|Cosmetics -> Hair fixing|INSECTICIDES