Pentachloroanisole

280.36

280.36

14D125MH3W

141502

2811

DTXSID2021103

2909309090

9.2

5.45

1.6178 (estimate)

108-110 °C

309 °C @ Press: 760 Torr

127.1ºC

1.577

less than 1 mg/mL at 77° F (NTP, 1992)

0-6°C

Oral-Mouse LD50: 318 mg/kg

Combustion produces toxic chloride gas

Oily, muddy

Insoluble in water.

Ethers

A halogenated ether derivative. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. Simple aromatic halogenated organic compounds are very unreactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms.

III

6.1(b)

2811

22

BZ8820000

Xn

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

P273

H302-H400

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

DHHS/NTP; Toxicology & Carcinogenesis Studies of Pentachloroanisole in F344/N Rats and B6C3F1 Mice (Gavage Studies) Technical Report Series No. 414 (1993) NIH Publication No. 93-3145

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material under ambient temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Pentachloroanisole was detected, not quantified, in secondary wastewater in Phoenix, AZ(1). Wastewater into the Lower Fox River, WI from 15 pulp and/or paper mills and 12 sewage treatment plants contained 0.05-0.38 ug/L of pentachloroanisole(2).|PENTACHLOROANISOLES IDENTIFIED IN THESE EFFLUENTS.

SEDIMENT: Surficial sediments of Manukau Harbor, New Zealand (5 sites): <0.1, <0.1, <0.1, 0.2, 0.1 ng/g dry wt(1). River and marine sediment from 9 of 12 sites sampled in Osaka, Japan contained pentachloroanisole ranging from 0.7 to 30 ug/kg dry wt with a median of positive samples of 3.5 ug/kg(2). Sediment from 6 estuaries in Japan contained pentachloroanisole levels ranging from not detectable to 1.1 ppb dry wt(3). SOIL: Soil in Japan on which pentachloronitrobenzene was extensively used, contained 0.009 ppm pentachloroanisole(4). Two 0-30 cm soil samples from an uncleaned sawmill in Finland that had been closed for more than 28 yr contained 200 and 806 ng/g pentachloroanisole, while that from two cleaned sawmills contained 3-29 ng/g in the 0-5 cm layer and 3-42 ng/g in the 5-10 cm layer(5,6).

RURAL/REMOTE: Pentachloroanisole is one of the more abundant high molecular weight halocarbons in the remote marine troposphere. Levels of pentachloroanisole in American Samoa in the northern hemisphere were 9.0 picograms/cu m (standard deviation 3.9 picograms/cu m), while those in the southern hemisphere, New Zealand was 2.1 picograms/cu m (standard deviation 0.8 picograms/cu m)(1). It was also detected in the lower troposphere over the southern Indian Ocean in the lower pg/cu m range(4). Air samples collected on a cruise on the Atlantic Ocean between 50 deg N and 50 deg S (22 samples): 1.8 - 40 pg/cu m with a median concn of 8.7 pg/cu m(2). The air samples were collected at a height of 20 m above sea level. Egbert, Ontario, Canada (143 samples between July 1988 and Sept 1989): annual mean 28 pg/cu m, max 130 pg/cu m(3).

highly toxic

LD50 Mouse oral 8.50 mg/kg|LD50 Mouse ip 8.40 mg/kg

... Toxicology and carcinogenesis studies were conducted by administering pentachloroanisole (>99% pure) in corn oil by gavage to groups of male and female F344/N rats and B6C3F1 mice for ... 2 yr. ... 2 YEAR STUDIES IN RATS: ... Doses selected for the 2 yr studies were 0, 10, 20, and 40 mg/kg for males and 0, 20, and 40 mg/kg for females. Groups of 70 male and 70 female rats were administered pentachloroanisole in corn oil by gavage 5 days/wk for up to 2 yr. ... 2 YEAR STUDIES IN MICE: ... Doses selected for the 2 yr studies were 0, 20, and 40 mg/kg. Groups of 70 male and 70 female mice were administered pentachloroanisole in corn oil by gavage 5 days/wk for up to 2 years. CONCLUSIONS: Under the conditions of these 2 yr gavage studies, there was some evidence of carcinogenic activity of pentachloroanisole in male F344/N rats based on increased incidences of benign pheochromocytomas of the adrenal medulla. There was equivocal evidence of carcinogenic activity of pentachloroanisole in female F344/N rats based on marginally increased incidences of benign pheochromocytomas of the adrenal medulla. There was some evidence of carcinogenic activity of pentachloroanisole in male B6C3F1 mice based on increased incidences of benign pheochromocytomas of the adrenal medulla and hemangiosarcomas of the liver. There was no evidence of carcinogenic activity of pentachloroanisole in female B6C3F1 mice given doses of 20 or 40 mg/kg~.

No commercial production of pentachloroanisole is known(3); its probable source is the biotic transformation of the biocide, pentachlorophenol (PCP) which is widely used as a wood preservative and slimicide in the wood products and leather industries(1-3). Pentachloroanisole's release after being formed in soil or water is believed to be the source of pentachloroanisole in the remote marine atmosphere(1).|Experiments performed in order to confirm that chlorinated anisoles could be formed in marine air by the action of widely-occurring haloperoxidase enzymes on anisole in the presence of chloride and hydrogen peroxide, failed to produced more highly chlorinated anisoles than dichloroanisole(1). Pentachloroanisole is a metabolite of PCP biodegradation by the fungi, Trichoderma virgatum(4). It was found on softwood chips treated with PCP(4). It is formed during composting of PCP(8). Pentachloroanisole was formed during the biodegradation of PCP in moist soil(3). However only a small percentage of PCP was converted to pentachloroanisole in the absence of molecular oxygen; after 24 days, 51.5% and 5.3% of applied PCP was converted to pentachloroanisole under aerobic and anaerobic conditions, respectively(2). After one vegetation period, 0.09% of the applied radioactivity resulting from the application of C14-PCP to flooded rice soil in a growth chamber was pentachloroanisole(5). In two years of monitoring aerobic and anaerobic sediment following the release of wastewater containing PCP-contaminated fuel oil into a creek, levels of pentachloroanisole did not exceed 10% of total PCP and pentachloroanisole concns(6). However the anaerobic site contained about twice the amount of pentachloroanisole indicating greater conversion. It is also a biodegradation product of pentachloronitrobenzene(7).|28-30 WK AFTER LAST APPLICATION OF (14)C-LABELED HCB (HEXACHLOROBENZENE) OR PCNB (PENTACHLORONITROBENZENE), PENTACHLOROANISOLE IDENTIFIED AS METABOLITE.

DEGRADATION OF PENTACHLOROPHENOL IN SOIL CORRELATED WITH CLAY MINERAL COMPOSITION, FREE IRON CONTENT, PHOSPHATE ABSORPTION COEFFICIENT & CATION EXCHANGE CAPACITY, HIGHLY CORRELATED WITH SOIL ORG MATTER. PENTACHLOROANISOLE WAS DEGRADATION PRODUCT.|STUDY OF DEGRADATION OF PENTACHLOROPHENOL (PCP) UNDER AEROBIC & ANAEROBIC CONDITIONS. PENTACHLOROANISOLE PRESENT IN BOTH AEROBIC & ANAEROBIC SOILS.|VERTICAL SOIL DISTRIBUTION OF PENTACHLORONITROBENZENE & METABOLITES SHOWED PEAK IN PARTS FROM 0-5 CM IN PLOWED SOIL & FROM 0-20 CM AFTER CULTIVATION. RESIDUAL AMT IN POTATO TUBERS GREATER IN SANDY SOIL THAN IN SOIL WITH MORE HUMUS & CLAY.|(14)C-LABELED PENTACHLORONITROBENZENE WAS APPLIED TO SOIL (36.1 KG/HA) UNDER OUTDOOR CONDITIONS & ONION BULBS WERE PLANTED. AT HARVEST, PENTACHLOROANISOLE OBTAINED FROM ROOT-PEEL EXTRACT.|For more Environmental Fate (Complete) data for PENTACHLOROANISOLE (9 total), please visit the HSDB record page.

Pentachloroanisole is resistant to chemical hydrolysis; it was not hydrolyzed by digestion in acidic or alkaline solutions and it was retained when pulp was cooked(1).|The rate constant for the vapor-phase reaction of pentachloroanisole with photochemically-produced hydroxyl radicals is estimated as 1.09X10-12 cu cm/molecule-sec at 25 °C(SRC) using a molecular structure-based estimation method(1,SRC). This corresponds to an atmospheric half-life of 15 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

1.45e+04|The BCF of Lake Ontario rainbow trout were 15,000 and 20,000 at water concns of 0.9 and 10 ng/L, respectively(1). In another experiment, the BCF of pentachloroanisole in guppies was 9100(2) with an uptake and clearance rate of 1710 mL/g-day and 0.32/day (half-life 2.2 days), respectively(2). The high clearance rate, which may be explained by the metabolic hydrolysis of pentachloroanisole to pentachlorophenol, may be why the BCF of pentachloroanisole is lower than the corresponding chlorinated benzene(2). Another investigator reported a much longer half-life of pentachloroanisole in fish lipid of 23 days(3) which is indicative of a potential for medium term bioaccumulation(6). A BCF of 8200 was estimated for pentachloroanisole(SRC), using an estimated log Kow of 5.45(4,SRC) and a recommended regression-derived equation(5). According to a suggested classification scheme(6), the measured and calculated BCFs are very high(SRC). In assessing bioaccumulation potential one must include the elimination rate(6), which even at the lower of the two available rates would reduce the potential for long term bioaccumulation(SRC).|Pentachloroanisole levels of 1-2 ng/kg were found in the blood and milk of 3 cows while they were fed technical commercial grade pentachlorophenol (20 mg/kg-day for 10 days and then 10 mg/kg-day for 60 days)(1).

Using an estimation method based on molecular connectivity indices(1), the Koc for pentachloroanisole is estimated to be 1490(SRC). According to a suggested classification scheme(2), this Koc value suggests that pentachloroanisole will have low mobility in soil(SRC). During biodegradation studies, pentachloroanisole was largely bound to the humin component of soil(3).

The Henry's Law constant for pentachloroanisole is estimated as 1.94X10-3 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that pentachloroanisole will volatilize rapidly from water(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as 5.6 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as 6.9 days(1,SRC). For comparison, the Henry's Law constant derived from corresponding air and seawater concn measurements during an ocean cruise, 3.3 pg/cu m and 2.9 ng/cu m, respectively(3) is 2.8 X10-5 atm-cu m/mol(SRC).

SURFACE WATER: Lower Fox River, WI, a heavily developed industrial basin with pulp and paper industry contained 0.002-0.02 ug/L and 0.02-0.05 ug/L of pentachloroanisole in water and seston, respectively(1). Pentachloroanisole was detected but not quantified in streams and rivers feeding Lakes Erie, Ontario, Huron, and Michigan, as well as the east and central basins of Lake Ontario(3). It was detected in the River Lee, Great Britain at levels generally <0.1 ug/L(2).|SEAWATER: Southern Atlantic Ocean (latitude 52 deg S, longitude 4 deg W; 10 m depth) 2.9 ng/cu m(1).|SNOW: Brown snow at Chesterfield Inlet, Northwest Territories in the Canadian arctic contained 1442 picograms/l of pentachloroanisole (1230 pg/l in melted snow and 4.3 ng/g in particles)(1). Analysis of air mass trajectories indicates that the source of the pollutant is western China(1).

Pentachloroanisole was one of the 40 most frequently found organic chemical residue in FDA's Total Diet Study of 1982-1984 and 1984-1985 with 33 and 30 positives among the 1872 individual food samples analyzed (2% incidence)(1). Results from FDA's Adult Total Diet Study in which the typical 14-day diet of a 16-19 yr male was collected throughout the US from market basket composite samples of 12 food groups (fiscal year, average intake (ug/kg body wt-day) are: FY78, 0.001; FY79, 0.001; FY80, 0.002; FY81/82, 0.001(2). Analogous study for infants and toddlers calculated that the intake of pentachloroanisole in ug/kg body wt-day was (fiscal year, average intake - infants, average intake - toddlers): FY78, 0.004, 0.007; FY79, 0.003,0.003; FY80, 0.003, 0.002; FY81/82, 0.002, 0.003(4) The food groups containing pentachloroanisole in the 1980-1982 survey are (class, concn range, average concn, number of positives): potatoes, trace, <0.0001 ppm, 1; oils and fats, trace-0.004 ppm, 0.0014 ppm, 22; sugar and adjuncts, trace - 0.001 ppm, 0.0001, 2(2). Oils and fats were the only food classes relevant to infants and toddlers that contained pentachloroanisole(4). The food groups containing pentachloroanisole in the 1979-1980 survey was (class, concn range, average concn, number of positives): meat, fish and poultry, trace, <0.0001 ppm, 1; fruits, 0.001 ppm, 0.001 ppm, 1; oils and fats, trace-0.009 ppm, 0.0012 ppm, 13; sugar and adjuncts, trace, <0.0001 ppm, 2(3). Pentachloroanisole was detected, but not quantified in commercial fish liver oil from Finland(5).

The general population is exposed to pentachloroanisole in food, especially oils and fats, and in ambient air. While not evident in FDA's Total Diet Studies, dietary exposure may occur by eating contaminated fish and fish products such as fish liver oil. Occupational expose, as well as general population exposure, may occur via dermal contact with soil or wood products that had been treated with pentachlorophenol. (SRC)

RELATIVE TISSUE CONCN & TOTAL BIRD LEVELS OF CHLOROANISOLES IN COMMERCIAL BROILERS REARED ON LITTER REPORTED. ALTHOUGH HIGHEST CONCN OCCURRED IN BONE & ADIPOSE TISSUE, GREATEST CONTRIBUTION TO WHOLE BIRD LEVELS IN EDIBLE TISSUE WAS PREDOMINANTLY PENTACHLOROANISOLE.|PENTACHLOROANISOLE (PCA) TAKEN UP RAPIDLY BY RAINBOW TROUT @ 0.025 MG/L IN WATER. AFTER 24 HR, CONCN IN LIVER, BLOOD, FAT & MUSCLE WERE 16, 6.5, 80, & 1.0 UG/G, RESPECTIVELY; T/2 OF 6.9, 6.3, 23, & 6.3 DAYS, RESPECTIVELY.|Tissue distribution, excretion and metabolism studies of pentachloroanisole (PCA), an environmental metabolite of pentachlorophenol (PCP), were conducted in the beagle dog and miniature pig following single oral doses (25 mg/kg) of radiolabelled PCA. PCA was readily demethylated by both species, with a half-life of 5-8 min. The resultant PCP was the major metabolite in dogs and pigs. In the dog, an average of 21.9% of the administered radiolabel was excreted in the urine and 62.3% in the feces during a 7 day period. Of the tissues analyzed, an average of 3.2% of the radiolabel remained in the liver, and blood and muscle accounted for averages of 3.0 and 2.3%, respectively, of the dose. Free and conjugated PCP were found in the urine of dogs; no PCA or tetrachlorohydroquinone (TCH) were found. In dog feces, PCP and a trace of polar material were observed; no PCA was excreted in dog feces. In the miniature pig, an average of 25.8% of the administered radiolabel was excreted in the urine and 32.0% in the feces during a 2-wk period. An average of 4.4% of the radiolabel was found in the liver, 8.8% in the blood, 7.1% in the muscle and 6.4% in the fat. In pig urine, PCP and conjugated PCP were the only metabolites observed; no PCA or TCH was found. Pig feces contained a trace of unchanged PCA; PCP and polar metabolites were also found. Since pig tissues retained a sizeable residue 2 wk after a single dose of PCA, various agents were used in an attempt to decrease the tissue level of radiolabel in pigs; anion exchange resin was found to be the most effective.|Toxicokinetics of pentachloroanisole (PCA) were studied in F344 rat and B6C3F1 mouse of both sexes by gavage at doses of 10, 20 and 40 mg/kg and by iv at 10 mg/kg. PCA was rapidly demethylated to pentachlorophenol (PCP) in both rat and mouse and the resulting PCP plasma concentrations were much higher than that of parent PCA due to the much smaller apparent volume of distribution of PCP. Peak plasma concentrations of PCA and PCP increased with dose in both rat and mouse. Bioavailability of PCA was low in both rat and mouse and was sex independent. The high plasma concentrations and relatively long biological half-life of PCP in both species after both iv and oral dosing with PCA indicate possible bioaccumulation of PCP upon multiple oral administrations of PCA.|Male Sprague-Dawley rats and New Zealand White rabbits were admin (14)C-labelled pentachloroanisole (PCA) in corn oil by gavage as single doses of 25 mg/kg and were then placed in individual metabolism cages for as long as 4 days. Peak blood level of radioactivity occurred 6 hr after admin of the dose to rats and between 3 and 4 hr in rabbits; the blood elimination half-life ranged from 8 to 15 hr in rats and averaged 6 hr in rabbits. Rats excreted an average of 54.2% of the admin radiolabel in the urine and 32.4% in the feces during the 96 hr following the dose; rabbits excreted an average of 84.2 and 13.1% of the radiolabel in the urine and faces, respectively, during this time. Examination of the metabolites in the rat showed that 60% of the urinary radioactivity was attributable to tetrachlorohydroquinone (TCH), 3% to free pentachlorophenol (PCP) and 29% to conjugated PCP; fecal metabolites were PCP (85.7%), TCH (4.3%) and polar metabolites (10.0%). In the rabbit, 58% of the urinary radioactivity was attributable to TCH, 8% to free PCP and 34% to conjugated PCP. Fecal metabolites consisted of PCP and conjugated material

PENTACHLOROPHENOL WAS METHYLATED INTO PENTACHLOROANISOLE BY TRICHODERMA VIRGATUM IN LIQUID CULTURES.|DURING THE DECOMPOSITION OF SODIUM PENTACHLOROPHENOLATE BY ALCALIGENES EUTROPHUS, AEROMONAS HYDROPHILIA VARIETY HYDROPHILIA AND VARIETY ANAEROGENES, AZOTOBACTER CHROOCOCCUM, AZOTOBACTER VINELANDII, FLAVOBACTERIUM AQUATILE, PSEUDOMONAS FLUORESCENS, CYTOPHAGA JOHNSONAE, CORYNEBACTERIUM AQUATICUM, BREVIBACTERIUM TESTACEUUM, AND ARTHROBACTER GLOBIFORMIS THE FOLLOWING /METABOLITES WERE IDENTIFIED/: PENTACHLOROANISOLE, 2,3,4,5-TETRACHLOROANISOLE, 2,3,4,6-TETRACHLOROANISOLE, 2,3,5,6-TETRACHLOROANISOLE, 2,3,4,5-TETRACHLOROPHENOL, 2,3,5,6-TETRACHLOROPHENOL, TETRACHLORORESORCINOL, TETRACHLOROHYDROQUINONE, AND TETRACHLOROACETECHOL DIACETATE, THE PRINCIPAL METABOLITE BEING PENTACHLOROPHENOL ACETATE. UP TO 6.2% OF THE SODIUM PENTACHLOROPHENOLATE WAS RECOVERED AS PENTCHLOROPHENOL ACETATE, WHILE ALL OTHER METABOLITES WERE FOUND IN AMT LESS THAN 1% OF STARTING CMPD.|Spent sawdust cultures of the Shiitake mushroom (Lentinus edodes) metabolized pentachlorophenol in soil to a significant (p<0.05) extent with 60.5, 57.3 and 44.4 % disappearance recorded for strains LE2 866 and R26 respectively. Addition of H202 markedly enhanced pentachlorophenol metabolism. Analysis of metabolites by GC/MS showed that pentachloroanisole was a metabolic product. These results suggest that there is potential for commercial application ln bioremediation.

467.74 Days

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

pentachloroanisole

98%

GEL PERMEATION CHROMATOGRAPHY USED FOR SAMPLE CLEANUP & GAS CHROMATOGRAPHY/MASS SPECTROMETRY USED FOR ANALYSIS OF FATHEAD FISH & WATER.|ANALYSIS OF VEGETABLE OILS FOR PENTACHLOROANISOLE BY ELECTRON CAPTURE GAS-LIQUID CHROMATOGRAPHY.|GCMS, fish, limit of quantitation 2.5 ppb